Projects per year
Personal profile
Research interests
Natural products isolated from bacteria, fungi and plants from both marine and terrestrial environments are a rich source of compounds of medicinal and agrochemical importance. We have published >130 papers which centre upon:-
- Structure elucidation and total synthesis of natural products
- Design and synthesis of probes to elucidate biosynthetic pathways and enzyme mechanisms
- Enantioselective synthesis of amino acids and heterocycles
- Isotopic labelling, biotransformations and reaction mechanisms
Professor Willis is a supervisor in the EPSRC Centre for Doctoral Training in Chemical Synthesis
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Projects
Revised: Engineering Trans-AT PKS antibiotic gene cluster to deliver bioactive compounds
31/07/14 → 31/01/21
Project: Research
Research Output
A Bioinspired Strategy for the Enantioselective Synthesis of Bicyclic Oxygen Heterocycles
Rodriguez Venegas, E. & Willis, C. L., 16 Mar 2020, In : Organic Letters. 5 p.Research output: Contribution to journal › Article (Academic Journal)
ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease
Evans, C., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. & Kehoe, P. G., 25 Jan 2020, In : Acta Neuropathologica. 18 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
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A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis
Walker, P. D., Rowe, M. T., Winter, A. J., Weir, A. N. M., Akter, N., Wang, L., Race, P. R., Williams, C., Song, Z., Simpson, T. J., Willis, C. L. & Crump, M. P., 6 Feb 2020, In : ACS Chemical Biology. 2020, 10 p.Research output: Contribution to journal › Article (Academic Journal)
Supervised Work
Lithiation—Borylation Methodology: Applications in the Synthesis of Polypropionate Fragment and Polyfluoromethylation Reactions of Organoboronic Esters
Author: Zhou, B., 7 May 2019Supervisor: Aggarwal, V. (Supervisor) & Willis, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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Maleidride Natural Products: Structural and Synthetic Studies
Author: Heard, D., 25 Jun 2019Supervisor: Cox, R. (Supervisor) & Willis, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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Mechanisms for the Generation of Structural Diversity in Polyketide Biosynthesis
Author: Walker, P., 7 May 2019Supervisor: Willis, C. (Supervisor), Race, P. (Supervisor) & Crump, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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