Projects per year
Personal profile
Research interests
Natural products isolated from bacteria, fungi and plants from both marine and terrestrial environments are a rich source of compounds of medicinal and agrochemical importance. We have published >130 papers which centre upon:-
- Structure elucidation and total synthesis of natural products
- Design and synthesis of probes to elucidate biosynthetic pathways and enzyme mechanisms
- Enantioselective synthesis of amino acids and heterocycles
- Isotopic labelling, biotransformations and reaction mechanisms
Professor Willis is a supervisor in the EPSRC Centre for Doctoral Training in Chemical Synthesis
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Projects
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Revised: Engineering Trans-AT PKS antibiotic gene cluster to deliver bioactive compounds
31/07/14 → 30/09/21
Project: Research
Research output
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A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge
et al., 11 Feb 2021, In: Marine Drugs. 19 p., 105.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile -
Cleaning the Cellular Factory – Deletion of McrA in Aspergillus oryzae NSAR1 and the generation of a novel kojic acid deficient strain for cleaner heterologous production of secondary metabolites
Dao, T. T., De Mattos-Shipley, K. M., Prosser, I. M., Williams, K., Zacharova, M. K., Lazarus, C. M., Willis, C. L. & Bailey, A. M., 18 Jan 2021, (Accepted/In press) In: Frontiers in Fungal Biology.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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A Bioinspired Strategy for the Enantioselective Synthesis of Bicyclic Oxygen Heterocycles
Rodriguez Venegas, E. & Willis, C. L., 16 Mar 2020, In: Organic Letters. 5 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review