Dr Chris R Neal

Research Output

Research Output per year

2005 2020

• 29 Article (Academic Journal)
• 2 Conference Abstract

Research Output per year

Research Output per year

Search results

• 2020

  Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress

  Jenkins, J. J., Mantell, J. M., Neal, C. R., Gholinia, A., Verkade, P., Nobbs, A. H. & Su, B., 2 Apr 2020, In : Nature Communications. 11, 14 p., 1626 (2020) .

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Oxidative stress
  • Nanopillars
  • bacteria
  • Electric Impedance
  • induction
  86 Downloads (Pure)

• A role for NPY-NPY2R signaling in albuminuric kidney disease

  Lay, A. C., Barrington, A. F., Hurcombe, J. A., Ramnath, R. D., Graham, M., Lewis, P. A., Wilson, M. C., Heesom, K. J., Butler, M. J., Perrett, R. M., Neal, C. R., Herbert, E., Mountjoy, E., Atan, D., Nair, V., Ju, W., Nelson, R. G., Kretzler, M., Satchell, S. C., McArdle, C. A. & 2 others, Welsh, G. I. & Coward, R. J. M., 19 Jun 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15862-15873 12 p., 202004651.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • neuropeptide Y2 receptor
  • Neuropeptide Y Receptors
  • Albuminuria
  • Neuropeptide Y
  • Kidney Diseases
  26 Downloads (Pure)

• Treatment with interleukin-33 is non-toxic and protects retinal pigment epithelium in an ageing model of outer retinal degeneration

  Clare, A. J., Copland, D. A., Nicholson, L. B., Liu, J., Neal, C. R., Moss, S., Dick, A. D. & Theodoropoulou, S., 20 Oct 2020, In : Journal of Cellular and Molecular Medicine. 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Interleukin-33
  • Retinal Degeneration
  • Retinal Pigment Epithelium
  • Macular Degeneration
  • High Fat Diet
  26 Downloads (Pure)
• 2019

  Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease: Syndecan 4 in diabetic kidney disease

  Ramnath, R. D., Butler, M. J., Newman, G., Desideri, S., Russell, A., Lay, A. C., Neal, C. R., Qiu, Y., Fawaz, S., Onions, K. L., Gamez, M., Crompton, M., Michie, C., Finch, N., Coward, R. J., Welsh, G. I., Foster, R. R. & Satchell, S. C., 2 Nov 2019, In : Kidney International.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Syndecan-4
  • Glomerular Filtration Barrier
  • Glycocalyx
  • Diabetic Nephropathies
  • Matrix Metalloproteinases
  5 Citations (Scopus)

  157 Downloads (Pure)

• The natural drug DIAVIT is protective in a type II mouse model of diabetic nephropathy

  Stevens, M., Neal, C. R., Craciun, E. C., Dronca, M., Harper, S. J. & Oltean, S., 13 Mar 2019, In : PLoS ONE. 14, 3, 20 p., e0212910.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • diabetic nephropathy
  • vascular endothelial growth factor A
  • Diabetic Nephropathies
  • human VEGFA protein
  • animal models
  1 Citation (Scopus)

  230 Downloads (Pure)

• VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy

  Onions, K. L., Gamez, M., Buckner, N. R., Baker, S. L., Betteridge, K. B., Desideri, S., Dallyn, B. P., Ramnath, R. D., Neal, C. R., Farmer, L. K., Mathieson, P. W., Gnudi, L., Alitalo, K., Bates, D. O., Salmon, A. H. J., Welsh, G. I., Satchell, S. C. & Foster, R. R., 1 Jan 2019, In : Diabetes. 68, 1, p. 172-187 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Vascular Endothelial Growth Factor Receptor
  • Albuminuria
  • Diabetic Nephropathies
  • Albumins
  • Permeability
  15 Citations (Scopus)

  248 Downloads (Pure)
• 2018

  A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli

  Desideri, S., Onions, K. L., Qiu, Y., Ramnath, R. D., Butler, M. J., Neal, C. R., King, M. L. R., Salmon, A. E., Saleem, M. A., Welsh, G. I., Michel, C. C., Satchell, S. C., Salmon, A. H. J. & Foster, R. R., 1 May 2018, In : Kidney International. 93, 5, p. 1086-1097 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Albumins
  • Permeability
  • Rodentia
  • Glycocalyx
  • Rodent Diseases
  12 Citations (Scopus)

  180 Downloads (Pure)

• Imaging the placental glycocalyx with transmission electron microscopy

  Fabre-Gray, A., Down, C., Neal, C., Foster, B., Satchell, S. & Bills, V., 15 Dec 2018, In : Placenta. 74, p. 59-61 3 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Glycocalyx
  • Transmission Electron Microscopy
  • Placenta
  • Tissue Fixation
  • Vascular Endothelium
  3 Citations (Scopus)

  178 Downloads (Pure)

• Novel hemodynamic structures in the human glomerulus

  Neal, C., Arkill, K., Bell, J., Betteridge, K., Bates, D., Winlove, C. P., Salmon, A. & Bristol, U., 1 Nov 2018, In : AJP - Renal Physiology. 315, 5, p. F1370- F1384 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Hemodynamics
  • Capillaries
  • Blood Vessels
  • Arterioles
  • Pressure
  6 Citations (Scopus)

  113 Downloads (Pure)

• Vascular endothelial growth factor-A₁₆₅b restores normal glomerular water permeability in a diphtheria-Toxin mouse model of glomerular injury

  Stevens, M., Neal, C. R., Salmon, A. H. J., Bates, D. O., Harper, S. J. & Oltean, S., 1 Apr 2018, In : Nephron Physiology. 139, 1, p. 51-62 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Diphtheria Toxin
  • Podocytes
  • Vascular Endothelial Growth Factor A
  • Permeability
  • Water
  2 Citations (Scopus)

  137 Downloads (Pure)
• 2017

  Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function

  Betteridge, K., Arkill, K., Neal, C., Harper, S., Foster, B., Satchell, S., Bates, D. & Salmon, A., Aug 2017, In : Journal of Physiology. 595, 15, p. 5015-5035 21 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Sialic Acids
  • Glycocalyx
  • Microvessels
  • Permeability
  • N-Acetylneuraminic Acid
  40 Citations (Scopus)

  326 Downloads (Pure)

• VEGF-A₁₆₅b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney

  Stevens, M., Neal, C. R., Salmon, A. H. J., Bates, D. O., Harper, S. J. & Oltean, S., 3 Jul 2017, In : Journal of Physiology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Proteinuria
  • Vascular Endothelial Growth Factor A
  • Protein Isoforms
  • Kidney
  • Podocytes
  9 Citations (Scopus)

  249 Downloads (Pure)
• 2015

  Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy

  Oltean, S., Qiu, Y., Ferguson, J. K., Stevens, M., Neal, C., Russell, A., Kaura, A., Arkill, K. P., Harris, K., Symonds, C., Lacey, K., Wijeyaratne, L., Gammons, M., Wylie, E., Hulse, R. P., Alsop, C., Cope, G., Damodaran, G., Betteridge, K. B., Ramnath, R. & 9 others, Satchell, S. C., Foster, R. R., Ballmer-Hofer, K., Donaldson, L. F., Barratt, J., Baelde, H. J., Harper, S. J., Bates, D. O. & Salmon, A. H. J., Aug 2015, In : Journal of the American Society of Nephrology. 26, 8, p. 1889-1904

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glycocalyx
  • Diabetic Nephropathies
  • Vascular Endothelial Growth Factor A
  • Permeability
  • Protein Isoforms
  71 Citations (Scopus)

  36 Downloads (Pure)
• 2014

  Origin Of Parietal Podocytes In Atubular Glomeruli Mapped By Lineage Tracing

  Schulte, K., Berger, K., Boor, P., Jirak, P., Gelman, IH., Arkill, K., Neal, C. R., Kriz, W., Floege, J., Smeets, B. & Moeller, MJ., 2014, In : Journal of the American Society of Nephrology. 25, 1, p. 129-141

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  31 Citations (Scopus)

• Resolution of the three dimensional structure of components of the glomerular filtration barrier

  Arkill, K. P., Qvortrup, K., Starborg, T., Mantell, J. M., Knupp, C., Michel, C. C., Harper, S. J., Salmon, A. H., Squire, J. M., Bates, D. O. & Neal, C. R., 1 Feb 2014, In : BMC Nephrology. 15, 1, p. 24

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glomerular Filtration Barrier
  • Podocytes
  • Glycocalyx
  • Basement Membrane
  • Endothelium
  35 Citations (Scopus)
• 2012

  3D Reconstruction of the Glycocalyx Structure in Mammalian Capillaries using Electron Tomography

  Arkill, KP., Neal, CR., Mantell, J., Michel, C., Qvortrup, K., Rostgaard, J., Bates, DO., Knupp, C. & Squire, JM., May 2012, In : Microcirculation. 19, p. 343 - 351 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Electron Microscope Tomography
  • Glycocalyx
  • Capillaries
  • Dysprosium
  • Endothelial Cells
  31 Citations (Scopus)

• Measuring protein concentration with entangled photons

  Crespi, A., Lobino, M., Matthews, J. C. F., Politi, A., Neal, C. R., Ramponi, R., Osellame, R. & O'Brien, J. L., 4 Jun 2012, In : Applied Physics Letters. 100, 23, 4 p., 233704.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  78 Citations (Scopus)

• VEGF165b overexpression restores normal glomerular water permeability in VEGF164-overexpressing adult mice

  Oltean, S., Neal, C. R., Mavrou, A., Patel, P., Ahad, T., Alsop, C., Lee, T., Sison, K., Qiu, Y., Harper, S. J., Bates, D. O. & Salmon, A. H. J., 1 Oct 2012, In : AJP - Renal Physiology. 303, 7, p. F1026-F1036

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Vascular Endothelial Growth Factor A
  • Permeability
  • Water
  • human VEGFA protein
  • Ultrafiltration
  19 Citations (Scopus)
• 2011

  Impaired vascular permeability regulation caused by the VEGF₁₆₅b splice variant in pre-eclampsia

  Bills, V., Salmon, AHJ., Harper, SJ., Overton, TG., Neal, CR., Jeffery, B., Soothill, PW. & Bates, DO., Sep 2011, In : BJOG: An International Journal of Obstetrics and Gynaecology. 118(10), p. 1253 - 1261 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  22 Citations (Scopus)

• Similar endothelial glycocalyx structures in microvessels from a range of mammalian tissues: evidence for a common filtering mechanism?

  Arkill, K. P., Knupp, C., Michel, C. C., Neal, C. R., Qvortrup, K., Rostgaard, J. & Squire, J. M., 7 Sep 2011, In : Biophysical Journal. 101, 5, p. 1046-1056 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glycocalyx
  • Microvessels
  • Psoas Muscles
  • Tannins
  • Mesentery
  54 Citations (Scopus)
• 2010

  Overexpression of VEGF165b in podocytes reduces glomerular permeability

  Qiu, Y., Ferguson, J., Oltean, S., Neal, CR., Kaura, A., Bevan, HS., Wood, E., Sage, LM., Lanati, S., Nowak, DG., Salmon, AHJ., Bates, DO. & Harper, SJ., 1 Sep 2010, In : Journal of the American Society of Nephrology. 21, 9, p. 1498 - 1509

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Podocytes
  • Vascular Endothelial Growth Factor A
  • Permeability
  • Glomerular Filtration Barrier
  • human VEGFA protein
  33 Citations (Scopus)
• 2009

  Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

  Salmon, AHJ., Neal, CR., Sage, LM., Glass, CA., Harper, SJ. & Bates, DO., 1 Jul 2009, In : Cardiovascular Research. 83, 1, p. 24 - 33

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Angiopoietin-1
  • Glycocalyx
  • Capillary Permeability
  • Microvessels
  • Permeability
  67 Citations (Scopus)

• New aspects of glomerular filtration barrier structure and function: five layers (at least) not three

  Salmon, AHJ., Neal, CR. & Harper, SJ., May 2009, In : Current Opinion in Nephrology and Hypertension. 18(3), p. 197 - 205

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glomerular Filtration Barrier
  • Diaphragm
  • Permeability
  • Podocytes
  • Endothelial Cells
  44 Citations (Scopus)
• 2008

  Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b

  Qiu, Y., Bevan, H., Weeraperuma, S., Wratting, D., Murphy, D., Neal, CR., Bates, DO. & Harper, SJ., Apr 2008, In : FASEB Journal. 22, 4, p. 1104 - 1112 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Lactation
  • human VEGFA protein
  • Intercellular Signaling Peptides and Proteins
  • Protein Isoforms
  • Breast
  55 Citations (Scopus)
• 2007

  Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space

  Salmon, AHJ., Toma, I., Sipos, A., Muston, PR., Harper, SJ., Bates, DO., Neal, CR. & Peti-Peterdi, J., Dec 2007, In : AJP - Renal Physiology. 293(6), p. F1777 - F1786

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glomerular Filtration Barrier
  • Capillaries
  • Permeability
  • Weights and Measures
  • Glomerular Basement Membrane
  56 Citations (Scopus)

• Glomerular Endothelial Glycocalyx Constitutes a Barrier to Protein Permeability

  Singh, A., Satchell, SC., Neal, CR., McKenzie, EA., Tooke, JE. & Mathieson, PW., Nov 2007, In : Journal of the American Society of Nephrology. 18 (11), p. 2885 - 2893 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  172 Citations (Scopus)

• Glomerular filtration into the subpodocyte space is highly restricted under physiological perfusion conditions.

  Neal, C. R., Muston, P. R., Njegovan, D., Verrill, R., Harper, S. J., Deen, WM. & Bates, D. O., Dec 2007, In : AJP - Renal Physiology. 293, 6, p. F1787-98

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Glomerular Filtration Barrier
  • Perfusion
  • Podocytes
  • Osmotic Pressure
  • Colloids
  46 Citations (Scopus)
• 2006

  Vascular endothelial growth factor increases the ultrafiltration coefficient in isolated intact Wistar rat glomeruli

  Salmon, AHJ., Neal, CR., Bates, DO. & Harper, SJ., Jan 2006, In : Journal of Physiology. 570 (1), p. 141 - 156 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Ultrafiltration
  • Vascular Endothelial Growth Factor A
  • Wistar Rats
  • Bovine Serum Albumin
  • ZM323881
  26 Citations (Scopus)
• 2005

  Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space

  Neal, CR., Crook, H., Bell, E., Harper, SJ. & Bates, DO., May 2005, In : Journal of the American Society of Nephrology. 16 (5), p. 1223 - 1235 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  74 Citations (Scopus)