Chris R Neal

2024

Maturation and Conformational Switching of a De Novo Designed Phase-Separating Polypeptide

Hilditch, A., Romanyuk, A., Hodgson, L. R., Mantell, J. M., Neal, C. R., Verkade, P., Obexer, R. J., Serpell, L. C., McManus, J. & Woolfson, D. N., 17 Apr 2024, In: Journal of the American Chemical Society. 146, 15, p. 10240–10245 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

2023

Correction: Back et al. A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge. Mar. Drugs 2021, 19, 105

Back, C. R., Stennett, H. L., Williams, S. E., Wang, L., Gomez, J. O., Abdulle, O. M., Duffy, T., Neal, C. R., Mantell, J., Jepson, M. A., Hendry, K. R., Powell, D., Stach, J. E. M., Essex-Lopresti, A. E., Willis, C. L., Curnow, P. & Race, P. R., 28 Mar 2023, In: Marine Drugs. 21, 4, 214.

Research output: Contribution to journal › Article (Academic Journal)

Open Access

Rapid expansion and visual specialisation of learning and memory centres in the brains of Heliconiini butterflies

Couto, A., Young, F. J., Atzeni, D., Marty, S., Melo-Flórez, L., Hebberecht Lopez, L., Monllor, M., Cicconardi, F., Neal, C. R., McMillan, W. O. & Montgomery, S. H., 7 Jul 2023, In: Nature Communications. 14, 1, 4024.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

22 Citations (Scopus)

2022

Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

Qiu, Y., Buffonge, S., Ramnath, R., Jenner, S., Fawaz, S., Arkill, K. P., Neal, C., Verkade, P., White, S. J., Hezzell, M., Salmon, A. H. J., Suleiman, M.-S., Welsh, G. I., Foster, R. R., Madeddu, P. & Satchell, S. C., 1 May 2022, In: Diabetologia. 65, 5, p. 879–894 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

28 Citations (Scopus)

118 Downloads (Pure)

Exploring the relevance of NUP93 variants in steroid-resistant nephrotic syndrome using next generation sequencing and a fly kidney model

Bierzynska, A., Bull, K., Miellet, S., Dean, P., Neal, C., Colby, E., McCarthy, H. J., Hegde, S., Sinha, M. D., Bugarin Diz, C., Stirrups, K., Megy, K., Mapeta, R., Penkett, C., Marsh, S., Forrester, N., Afzal, M., Stark, H., BioResource, N. & Williams, M. & 4 others, Welsh, G. I., Koziell, A. B., Hartley, P. S. & Saleem, M. A., 24 Feb 2022, (E-pub ahead of print) In: Pediatric Nephrology. 37, 11, p. 2643-2656 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

11 Citations (Scopus)

59 Downloads (Pure)

Reduced glomerular filtration in diabetes is attributable to loss of density and increased resistance of glomerular endothelial cell fenestrations

Finch, N. C., Fawaz, S., Neal, C. R., Butler, M. J., Salmon, A., Lay, A. C., Stevens, M., Mellor, H. H., Harper, S. J., Welsh, G. I., Foster, R. & Satchell, S. C., 15 Mar 2022, (E-pub ahead of print) In: Journal of the American Society of Nephrology. 33, 6, p. 1120-1136 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

19 Citations (Scopus)

243 Downloads (Pure)

Visualising the endothelial glycocalyx in dogs

Lawrence-Mills, S., Neal, C. R., Satchell, S. C., Welsh, G. I., Foster, R. R. & Finch, N. C., 1 Jul 2022, In: Veterinary Journal. 285, 4 p., 105844.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

2 Citations (Scopus)

91 Downloads (Pure)

2021

A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function

McCaughey, J., Stevenson, N. L., Mantell, J. M., Neal, C. R., Heesom, K. & Stephens, D. J., 7 Sept 2021, In: Journal of Cell Science. 134, 17, jcs259075.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

22 Citations (Scopus)

170 Downloads (Pure)

A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge

et al., 11 Feb 2021, In: Marine Drugs. 19, 2, 19 p., 105.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

24 Citations (Scopus)

243 Downloads (Pure)

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors

Scott, L. M., Vincent, E. E., Hudson, N., Neal, C. R., Jones, N., Lavelle, E. C., Campbell, M., Halestrap, A. P., Dick, A. D. & Theodoropoulou, S., 22 Apr 2021, In: JCI Insight. 6, 8, 21 p., e129429.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

10 Citations (Scopus)

66 Downloads (Pure)

Maintenance of complex I and its supercomplexes by NDUF-11 is essential for mitochondrial structure, function and health

Knapp-Wilson, A. L., C. Pereira, G., Buzzard, E. J., Ford, H. C., Neal, C. R., Verkade, P., Halestrap, A. P., Gold, V. A. M., Kuwabara, P. E. & Collinson, I. R., 9 Jul 2021, In: Journal of Cell Science. 134, 13, 17 p., jcs258399.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

27 Citations (Scopus)

179 Downloads (Pure)

2020

Antibacterial effects of nanopillar surfaces are mediated by cell impedance, penetration and induction of oxidative stress

Jenkins, J. J., Mantell, J. M., Neal, C. R., Gholinia, A., Verkade, P., Nobbs, A. H. & Su, B., 2 Apr 2020, In: Nature Communications. 11, 14 p., 1626 (2020) .

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

321 Citations (Scopus)

214 Downloads (Pure)

A role for NPY-NPY2R signaling in albuminuric kidney disease

Lay, A. C., Barrington, A. F., Hurcombe, J. A., Ramnath, R. D., Graham, M., Lewis, P. A., Wilson, M. C., Heesom, K. J., Butler, M. J., Perrett, R. M., Neal, C. R., Herbert, E., Mountjoy, E., Atan, D., Nair, V., Ju, W., Nelson, R. G., Kretzler, M., Satchell, S. C. & McArdle, C. A. & 2 others, Welsh, G. I. & Coward, R. J. M., 7 Jul 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15862-15873 12 p., 202004651.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

16 Citations (Scopus)

144 Downloads (Pure)

Treatment with interleukin-33 is non-toxic and protects retinal pigment epithelium in an ageing model of outer retinal degeneration

Clare, A. J., Copland, D. A., Nicholson, L. B., Liu, J., Neal, C. R., Moss, S., Dick, A. D. & Theodoropoulou, S., 29 Nov 2020, In: Journal of Cellular and Molecular Medicine. 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

6 Citations (Scopus)

85 Downloads (Pure)

2019

Blocking matrix metalloproteinase-mediated syndecan-4 shedding restores the endothelial glycocalyx and glomerular filtration barrier function in early diabetic kidney disease: Syndecan 4 in diabetic kidney disease

Ramnath, R. D., Butler, M. J., Newman, G., Desideri, S., Russell, A., Lay, A. C., Neal, C. R., Qiu, Y., Fawaz, S., Onions, K. L., Gamez, M., Crompton, M., Michie, C., Finch, N., Coward, R. J., Welsh, G. I., Foster, R. R. & Satchell, S. C., 2 Nov 2019, (E-pub ahead of print) In: Kidney International.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

57 Citations (Scopus)

449 Downloads (Pure)

The natural drug DIAVIT is protective in a type II mouse model of diabetic nephropathy

Stevens, M., Neal, C. R., Craciun, E. C., Dronca, M., Harper, S. J. & Oltean, S., 13 Mar 2019, In: PLoS ONE. 14, 3, 20 p., e0212910.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

9 Citations (Scopus)

293 Downloads (Pure)

VEGFC reduces glomerular albumin permeability and protects against alterations in VEGF receptor expression in diabetic nephropathy

Onions, K. L., Gamez, M., Buckner, N. R., Baker, S. L., Betteridge, K. B., Desideri, S., Dallyn, B. P., Ramnath, R. D., Neal, C. R., Farmer, L. K., Mathieson, P. W., Gnudi, L., Alitalo, K., Bates, D. O., Salmon, A. H. J., Welsh, G. I., Satchell, S. C. & Foster, R. R., 1 Jan 2019, In: Diabetes. 68, 1, p. 172-187 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

56 Citations (Scopus)

382 Downloads (Pure)

2018

A novel assay provides sensitive measurement of physiologically relevant changes in albumin permeability in isolated human and rodent glomeruli

Desideri, S., Onions, K. L., Qiu, Y., Ramnath, R. D., Butler, M. J., Neal, C. R., King, M. L. R., Salmon, A. E., Saleem, M. A., Welsh, G. I., Michel, C. C., Satchell, S. C., Salmon, A. H. J. & Foster, R. R., 1 May 2018, In: Kidney International. 93, 5, p. 1086-1097 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

33 Citations (Scopus)

334 Downloads (Pure)

Imaging the placental glycocalyx with transmission electron microscopy

Fabre-Gray, A., Down, C., Neal, C., Foster, B., Satchell, S. & Bills, V., 15 Dec 2018, In: Placenta. 74, p. 59-61 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

12 Citations (Scopus)

343 Downloads (Pure)

Novel hemodynamic structures in the human glomerulus

Neal, C., Arkill, K., Bell, J., Betteridge, K., Bates, D., Winlove, C. P., Salmon, A. & Harper, S. J., 1 Nov 2018, In: AJP - Renal Physiology. 315, 5, p. F1370- F1384 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

30 Citations (Scopus)

185 Downloads (Pure)

Vascular endothelial growth factor-A₁₆₅b restores normal glomerular water permeability in a diphtheria-Toxin mouse model of glomerular injury

Stevens, M., Neal, C. R., Salmon, A. H. J., Bates, D. O., Harper, S. J. & Oltean, S., 1 Apr 2018, In: Nephron Physiology. 139, 1, p. 51-62 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

4 Citations (Scopus)

272 Downloads (Pure)

2017

Sialic acids regulate microvessel permeability, revealed by novel in vivo studies of endothelial glycocalyx structure and function

Betteridge, K., Arkill, K., Neal, C., Harper, S., Foster, B., Satchell, S., Bates, D. & Salmon, A., Aug 2017, In: Journal of Physiology. 595, 15, p. 5015-5035 21 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

104 Citations (Scopus)

391 Downloads (Pure)

VEGF-A₁₆₅b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF-A splice isoforms from the kidney

Stevens, M., Neal, C. R., Salmon, A. H. J., Bates, D. O., Harper, S. J. & Oltean, S., 3 Jul 2017, (E-pub ahead of print) In: Journal of Physiology.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

17 Citations (Scopus)

334 Downloads (Pure)

2015

Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy

Oltean, S., Qiu, Y., Ferguson, J. K., Stevens, M., Neal, C., Russell, A., Kaura, A., Arkill, K. P., Harris, K., Symonds, C., Lacey, K., Wijeyaratne, L., Gammons, M., Wylie, E., Hulse, R. P., Alsop, C., Cope, G., Damodaran, G., Betteridge, K. B. & Ramnath, R. & 9 others, Satchell, S. C., Foster, R. R., Ballmer-Hofer, K., Donaldson, L. F., Barratt, J., Baelde, H. J., Harper, S. J., Bates, D. O. & Salmon, A. H. J., Aug 2015, In: Journal of the American Society of Nephrology. 26, 8, p. 1889-1904

Research output: Contribution to journal › Article (Academic Journal) › peer-review

117 Citations (Scopus)

36 Downloads (Pure)

2014

Origin Of Parietal Podocytes In Atubular Glomeruli Mapped By Lineage Tracing

Schulte, K., Berger, K., Boor, P., Jirak, P., Gelman, I., Arkill, K., Neal, C. R., Kriz, W., Floege, J., Smeets, B. & Moeller, M., 2014, In: Journal of the American Society of Nephrology. 25, 1, p. 129-141

Research output: Contribution to journal › Article (Academic Journal) › peer-review

41 Citations (Scopus)

Resolution of the three dimensional structure of components of the glomerular filtration barrier

Arkill, K. P., Qvortrup, K., Starborg, T., Mantell, J. M., Knupp, C., Michel, C. C., Harper, S. J., Salmon, A. H., Squire, J. M., Bates, D. O. & Neal, C. R., 1 Feb 2014, In: BMC Nephrology. 15, 1, p. 24

Research output: Contribution to journal › Article (Academic Journal) › peer-review

61 Citations (Scopus)

2012

3D Reconstruction of the Glycocalyx Structure in Mammalian Capillaries using Electron Tomography

Arkill, K., Neal, C., Mantell, J., Michel, C., Qvortrup, K., Rostgaard, J., Bates, D., Knupp, C. & Squire, J., May 2012, In: Microcirculation. 19, p. 343 - 351 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

39 Citations (Scopus)

Measuring protein concentration with entangled photons

Crespi, A., Lobino, M., Matthews, J. C. F., Politi, A., Neal, C. R., Ramponi, R., Osellame, R. & O'Brien, J. L., 4 Jun 2012, In: Applied Physics Letters. 100, 23, 4 p., 233704.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

121 Citations (Scopus)

VEGF165b overexpression restores normal glomerular water permeability in VEGF164-overexpressing adult mice

Oltean, S., Neal, C. R., Mavrou, A., Patel, P., Ahad, T., Alsop, C., Lee, T., Sison, K., Qiu, Y., Harper, S. J., Bates, D. O. & Salmon, A. H. J., 1 Oct 2012, In: AJP - Renal Physiology. 303, 7, p. F1026-F1036

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

2011

Impaired vascular permeability regulation caused by the VEGF₁₆₅b splice variant in pre-eclampsia

Bills, V., Salmon, A., Harper, S., Overton, T., Neal, C., Jeffery, B., Soothill, P. & Bates, D., Sept 2011, In: BJOG: An International Journal of Obstetrics and Gynaecology. 118(10), p. 1253 - 1261 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

29 Citations (Scopus)

Similar endothelial glycocalyx structures in microvessels from a range of mammalian tissues: evidence for a common filtering mechanism?

Arkill, K. P., Knupp, C., Michel, C. C., Neal, C. R., Qvortrup, K., Rostgaard, J. & Squire, J. M., 7 Sept 2011, In: Biophysical Journal. 101, 5, p. 1046-1056 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

70 Citations (Scopus)

2010

Overexpression of VEGF165b in podocytes reduces glomerular permeability

Qiu, Y., Ferguson, J., Oltean, S., Neal, C., Kaura, A., Bevan, H., Wood, E., Sage, L., Lanati, S., Nowak, D., Salmon, A., Bates, D. & Harper, S., 1 Sept 2010, In: Journal of the American Society of Nephrology. 21, 9, p. 1498 - 1509

Research output: Contribution to journal › Article (Academic Journal) › peer-review

40 Citations (Scopus)

2009

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

Salmon, A., Neal, C., Sage, L., Glass, C., Harper, S. & Bates, D., 1 Jul 2009, In: Cardiovascular Research. 83, 1, p. 24 - 33

Research output: Contribution to journal › Article (Academic Journal) › peer-review

86 Citations (Scopus)

New aspects of glomerular filtration barrier structure and function: five layers (at least) not three

Salmon, A., Neal, C. & Harper, S., May 2009, In: Current Opinion in Nephrology and Hypertension. 18(3), p. 197 - 205

Research output: Contribution to journal › Article (Academic Journal) › peer-review

49 Citations (Scopus)

2008

Mammary alveolar development during lactation is inhibited by the endogenous antiangiogenic growth factor isoform, VEGF165b

Qiu, Y., Bevan, H., Weeraperuma, S., Wratting, D., Murphy, D., Neal, C., Bates, D. & Harper, S., Apr 2008, In: FASEB Journal. 22, 4, p. 1104 - 1112 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

60 Citations (Scopus)

2007

Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space

Salmon, A., Toma, I., Sipos, A., Muston, P., Harper, S., Bates, D., Neal, C. & Peti-Peterdi, J., Dec 2007, In: AJP - Renal Physiology. 293(6), p. F1777 - F1786

Research output: Contribution to journal › Article (Academic Journal) › peer-review

62 Citations (Scopus)

Glomerular Endothelial Glycocalyx Constitutes a Barrier to Protein Permeability

Singh, A., Satchell, S., Neal, C., McKenzie, E., Tooke, J. & Mathieson, P., Nov 2007, In: Journal of the American Society of Nephrology. 18 (11), p. 2885 - 2893 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

240 Citations (Scopus)

Glomerular filtration into the subpodocyte space is highly restricted under physiological perfusion conditions.

Neal, C. R., Muston, P. R., Njegovan, D., Verrill, R., Harper, S. J., Deen, W. & Bates, D. O., Dec 2007, In: AJP - Renal Physiology. 293, 6, p. F1787-98

Research output: Contribution to journal › Article (Academic Journal) › peer-review

55 Citations (Scopus)

2006

Vascular endothelial growth factor increases the ultrafiltration coefficient in isolated intact Wistar rat glomeruli

Salmon, A., Neal, C., Bates, D. & Harper, S., Jan 2006, In: Journal of Physiology. 570 (1), p. 141 - 156 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

31 Citations (Scopus)

2005

Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space

Neal, C., Crook, H., Bell, E., Harper, S. & Bates, D., May 2005, In: Journal of the American Society of Nephrology. 16 (5), p. 1223 - 1235 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

90 Citations (Scopus)

Dr Chris R Neal

Research output

Search results