Projects per year
My research focuses on the regulation of cartilage and bone homeostasis in development and in disease, particularly osteoarthritis. I use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.
We have a number of projects running, including pilot experiments on the affects of gravity on the zebrafish skeletal system (with experiments to be run in hypergravity at the European Space Centre and in microgravity on the International Space Station.
We are characterising zebrafish mutants that we have generated carrying mutations to genes known to increase human susceptibility to osteoarthritis.
We are characterising zebrafish models of Stickler syndrome
1/10/18 → 31/03/19
VdGOA: Effect of treatment with Vitamin D and synthetic analogues in preventing intestine inflammatory disease and osteoarthritis in zebrafish larvae
23/06/18 → 31/07/18
3D assessment of intervertebral disc degeneration in zebrafish identifies changes to bone density that prime disc diseaseKague, E., Turci, F., Newham, E., Yang, Y., Robson Brown, K., Aglan, M. S., Otaify, G. A., Temtamy, S. A., Ruiz-Perez, V. L., Cross, S., Royall, C. P., Witten, P. E. & Hammond, C., 15 Mar 2021, (Accepted/In press) In: Bone Research.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Exposure to hypergravity during zebrafish development alters cartilage material properties and strain distribution.Lawrence, E. A., Aggleton, J., van Loon, J., Godivier, J., Harniman, R. L., Pei, J., Nowlan, N. & Hammond, C., 9 Feb 2021, In: Bone and Joint Research. 10, 2, p. 137–148 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile1 Citation (Scopus)31 Downloads (Pure)
Stevenson, N. L., Bergen, D. J. M., Prada-Sanchez, E., Hammond, C. & Stephens, D. J., 7 Jun 2021, In: Journal of Cell Biology. 220, 6, 18 p., e202005166.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile6 Downloads (Pure)