Projects per year
Our group's research focuses on the regulation of cartilage and bone homeostasis in development and in disease states such as osteoarthritis, osteoporosis and Stickler syndrome as well as during repair and regeneration. We are particularly interested in the interplay between genes and environmental cues such as mechanical loading, diet, and metabolism. We use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.
We have a number of projects running in collaboration with clinicians, engineers and epidemiologists.
Additionally, with Emma Vincent, I colead an Elizabeth Blackwell Institute research strand called 'Mechanisms to Populations' which aims to help overcome the barriers to interdisciplinary work in epidmiology and functional biological studies. For mroe information on the strand please see:
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1/04/22 → 31/03/25
1/10/18 → 31/03/19
Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafishGodivier, J. M., Lawrence, L., Wang, M., Hammond, C. & Nowlan, N., 5 May 2022, In: Journal of Anatomy.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access
Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal diseaseBergen, D. J. M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S. E., Frysz, M., Croucher, P. I., Flik, G., Richardson, R. J., Kemp, J. P., Hammond, C. L. & Metz, J. R., 21 Jan 2022, In: BMC Biology. 20, 1, 25 p., 21.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile8 Downloads (Pure)
3D assessment of intervertebral disc degeneration in zebrafish identifies changes to bone density that prime disc diseaseKague, E., Turci, F., Newham, E., Yang, Y., Robson Brown, K., Aglan, M. S., Otaify, G. A., Temtamy, S. A., Ruiz-Perez, V. L., Cross, S., Royall, C. P., Witten, P. E. & Hammond, C., 31 Aug 2021, (E-pub ahead of print) In: Bone Research.
Research output: Contribution to journal › Article (Academic Journal) › peer-review