Dr Chrissy L Hammond

MBiochem(Oxon.), PhD(Lond.)

  • BS8 1TD

20052020

Research output per year

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Personal profile

Research interests

My research focuses on the regulation of cartilage and bone homeostasis in development and in disease, particularly osteoarthritis. I use the zebrafish as a model because it combines excellent genetics with beautiful imaging possibilities, which allow us to study the development of the skeletal system dynamically in vivo.

We have a number of projects running, including pilot experiments on the affects of gravity on the zebrafish skeletal system (with experiments to be run in hypergravity at the European Space Centre and in microgravity on the International Space Station.

We are characterising zebrafish mutants that we have generated carrying mutations to genes known to increase human susceptibility to osteoarthritis.

We are characterising zebrafish models of Stickler syndrome

 

 

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Projects

Research Output

  • 29 Article (Academic Journal)
  • 1 Review article (Academic Journal)

A rare mutation in SMAD9 associated with high bone mass identifies the SMAD-dependent BMP signalling pathway as a potential anabolic target for osteoporosis

Brown, M. A., Hammond, C., Kemp, J. P., Duncan, E. L. & AOGC Consortium, 16 Sep 2019, In : Journal of Bone and Mineral Research. 40 p.

Research output: Contribution to journalArticle (Academic Journal)

  • Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines

    Newham, E., Kague, E., Aggleton, J. A., Fernee, C., Brown, K. R. & Hammond, C. L., 6 Nov 2019, In : Journal of the Royal Society Interface. 16, 160, 8 p., 0430.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 1 Citation (Scopus)
    104 Downloads (Pure)

    Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish

    Kague, E., Hughes, S. M., Lawrence, E. A., Cross, S., Martin-Silverstone, E., Hammond, C. L. & Hinits, Y., 1 Aug 2019, In : FASEB Journal. 33, 8, p. 9116-9130 15 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 4 Citations (Scopus)
    213 Downloads (Pure)

    Activities

    • 1 Schools engagement

    Authentic Biology at Cotham School

    Chrissy L Hammond (Organiser)

    Nov 2012Dec 2015

    Activity: Talk or presentation typesSchools engagement