Projects per year
Current work in the lab ranges from eukaryotic translation initiation, via regulation of translation termination to co-translational translocation of membrane proteins via the bacterial holo-translocon. We are particularly interested in how cells recognize problems during protein synthesis and target the defective proteins and their encoding mRNAs to degradation. These processes are vital to all organisms, and even minor problems in mRNA or protein quality control mechanisms give rise to diseases. Our research is funded by the BBSRC and MRC and recently via a Wellcome Trust Investigator Award.
In all our projects, we rely on biochemical methods, using in vitro translation systems. Most projects in the lab also involve biophysics and structural biology, crystallography and cryo-EM. We have established a Wellcome Trust-funded GW4 Facility for high-resolution Cryo-EM with a 200kV Talos Arctica with energy filter and K2 Direct Electron Detector. Image processing is supported by a BBSRC-funded BlueCryo high-performance computing cluster.
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ADDovenom: ADDovenom: Novel Snakebite Therapy Platform of Unparalleled Efficacy, Safety and Affordability
1/10/20 → 30/09/24
Project: Research, Parent
1/05/17 → 30/04/22
Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNAPowers, K. T., Stevenson-Jones, F. R., Yadav Kadapalakere, S., Bufton, J. C., Borucu, U., Shen, D. & Berger-Schaffitzel, C. H., 21 Jul 2021, In: Nucleic Acids Research. 49, 13, p. 7665-7679 15 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile12 Downloads (Pure)
Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen Candida albicansAlaalm, L., Crunden, J. L., Butcher, M., Obst, U., Whealy, R., Williamson, C., O'Brien, H., Berger-Schaffitzel, C. H., Ramage, G., Spencer, J. & Diezmann, S., 27 Aug 2021, In: Frontiers in Cellular and Infection Microbiology. 11, 637836.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access
Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS-CoV-2 Spike Protein*Shoemark, D. K., Colenso, C. K., Toelzer, C., Gupta, K., Sessions, R. B., Sessions, R. B., Davidson, A. D., Berger, I., Schaffitzel, C., Spencer, J. & Mulholland, A. J., 22 Mar 2021, In: Angewandte Chemie. 60, 13, 13 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile176 Downloads (Pure)