Professor Christiane H Berger-Schaffitzel

MSc(Hannover), PhD(Zurich), Habiliation (E.T.H.Zurich)

  • BS8 1TD

20062022

Research output per year

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Personal profile

Research interests

Current work in the lab ranges from eukaryotic translation initiation, via regulation of translation termination to co-translational translocation of membrane proteins via the bacterial holo-translocon. We are particularly interested in how cells recognize problems during protein synthesis and target the defective proteins and their encoding mRNAs to degradation. These processes are vital to all organisms, and even minor problems in mRNA or protein quality control mechanisms give rise to diseases. Our research is funded by the BBSRC and MRC and recently via a Wellcome Trust Investigator Award.

In all our projects, we rely on biochemical methods, using in vitro translation systems. Most projects in the lab also involve biophysics and structural biology, crystallography and cryo-EM. We have established a Wellcome Trust-funded GW4 Facility for high-resolution Cryo-EM with a 200kV Talos Arctica with energy filter and K2 Direct Electron Detector. Image processing is supported by a BBSRC-funded BlueCryo high-performance computing cluster. 

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Projects

Research Output

  • 40 Article (Academic Journal)
  • 5 Chapter in a book
  • 1 Comment/debate (Academic Journal)
  • 1 Review article (Academic Journal)

High-Throughput Production of Influenza Virus-Like Particle (VLP) Array by Using VLP-factory™, a MultiBac Baculoviral Genome Customized for Enveloped VLP Expression

Sari-Ak, D., Bahrami, S., Laska, M., Drncova, P., Fitzgerald, D. J., Berger-Schaffitzel, C., Garzoni, F. & Berger, I., 3 Jul 2019, High-Throughput Protein Production and Purification: Methods and Protocols. Vincentelli, R. (ed.). Humana Press, p. 213-226 14 p. (Methods in Molecular Biology; vol. 2025).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

  • MultiBac: Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian Cells

    Gupta, K., Toelzer, C., Sari-Ak, D., Fitzgerald, D. J., Berger-Schaffitzel, C. & Berger, I., Mar 2019, In : Viruses. 11, 3, 14 p., 198.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 267 Downloads (Pure)

    Structure and Dynamics of the Central Lipid Pool and Proteins of the Bacterial Holo-Translocon

    Martin, R., Larsen, A. H., Corey, R. A., Midtgaard, S. R., Frielinghaus, H., Schaffitzel, C., Arleth, L. & Collinson, I., 21 May 2019, In : Biophysical Journal. 116, 10, p. 1931-1940 10 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 2 Citations (Scopus)
    129 Downloads (Pure)