Professor Christoph Wuelfing

Dip(Munich), PhD(Munich)

  • BS8 1TD

20092020

Research output per year

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Research Output

  • 21 Article (Academic Journal)
  • 2 Chapter in a book
2019

PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and tumor target cells within the tumor

Ambler, R., Edmunds, G., Morgan, D. & Wuelfing, C., 25 Apr 2019, (Submitted) In : Science Signaling.

Research output: Contribution to journalArticle (Academic Journal)

Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

Clark, D. J., McMillan, L. E., Tan, S. L., Bellomo, G., Massoue, C., Thompson, H., Mykhaylechko, L., Alibhai, D., Ruan, X., Singleton, K. L., Du, M., Hedges, A., Schwartzberg, P. L., Verkade, P., Murphy, R. F. & Wuellfing, C., 30 Oct 2019, In : eLife. 8, 29 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
113 Downloads (Pure)
2017

Image-based spatiotemporal causality inference for protein signaling networks

Ruan, X., Wuelfing, C. & Murphy, R., 12 Jul 2017, In : Bioinformatics. 33, 14

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
206 Downloads (Pure)

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

Britton, G., Ambler, R. C. J., Clark, D., Hill, E., Tunbridge, H., McNally, K., Burton, B., Butterweck, P., Sabatos-Peyton, C., Hampton-O'Neil, L., Verkade, P., Wuelfing, C. & Wraith, D., 23 Jan 2017, In : eLife. 6, 18 p., e20003.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
316 Downloads (Pure)

Systems Imaging of the Immune Synapse

Wuelfing, C., Ambler, R., RUAN, X. & Murphy, R. F., 2017, The Immune Synapse : Methods and Protocols. Humana Press, Vol. 1584. p. 409-423 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
2 Citations (Scopus)
172 Downloads (Pure)
2016

Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics

Roybal, K. T., Buck, T. E., Ruan, X., Cho, B. H., Clark, D. J., Ambler, R. C. J., Tunbridge, H. M., Zhang, J., Verkade, P., Wuelfing, C. & Murphy, R. F., 19 Apr 2016, In : Science Signaling. 9, 424, 13 p., rs3.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
305 Downloads (Pure)

Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1

Ruffo, E., Malarcance, V., Larsen, S., Das, R., Patrussi, L., Wülfing, C., Biskup, C., Kapnick, S., Verbist, K., Tedrick, P., Schwartzberg, P., Baldari, C., Rubio, I., Nichols, K., Snow, A., Baldanzi, G. & Graziani, A., 13 Jan 2016, In : Science Translational Medicine. 8, 321, 321ra7.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2015

Cellular structures controlling T cell signaling in time and space

Wülfing, C. & Roybal, K., 26 Oct 2015, Encyclopedia of Cell Biology. bradshaw, R. & Stahl, P. (eds.). Waltham, MA: Academic Press, Vol. 3. p. 677-686

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

78 Downloads (Pure)

Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network

Roybal, K. T., Mace, E. M., Mantell, J. M., Verkade, P., Orange, J. S. & Wülfing, C., 3 Aug 2015, In : PLoS ONE. 10, 8, 22 p., e0133299.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
297 Downloads (Pure)

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

Roybal, K. T., Mace, E. M., Clark, D. J., Leard, A. D., Herman, A., Verkade, P., Orange, J. S. & Wülfing, C., 3 Aug 2015, In : PLoS ONE. 10, 8, p. e0133231

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
301 Downloads (Pure)
2014

T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice

Sinai, P., Dozmorov, I. M., Song, R., Schwartzberg, P. L., Wakeland, E. K., Wülfing, C. & Wülfing, C., Dec 2014, In : European Journal of Immunology. 44, 12, p. 3522-31 10 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)
2013

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development

Paster, W., Brockmeyer, C., Fu, G., Simister, P. C., de Wet, B., Martinez-Riaño, A., Hoerter, J. A. H., Feller, S. M., Wülfing, C., Gascoigne, N. R. J., Acuto, O. & Wülfing, C., 1 Apr 2013, In : Journal of Immunology. 190, 7, p. 3749-56 8 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

The actin-driven spatiotemporal organization of T-cell signaling at the system scale

Roybal, K. T., Sinai, P., Verkade, P., Murphy, R. & Wülfing, C., Nov 2013, In : Immunological Reviews. 256, 1, p. 133-147 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
20 Citations (Scopus)
470 Downloads (Pure)

The lymphoid lineage–specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells

Liang, Y., Cucchetti, M., Roncagalli, R., Yokosuka, T., Malzac, A., Bertosio, E., Imbert, J., Nijman, I., Suchanek, M., Saito, T., Wülfing, C., Malissen, B. & Malissen, M., 2013, In : Nature Immunology. doi:10.1038/ni.2634.

Research output: Contribution to journalArticle (Academic Journal)

57 Citations (Scopus)
2012

Mechanism and function of Vav1 localization in TCR signaling

Ksionda, O., Saveliev, A., Köchl, R., Rapley, J., Faroudi, M., Smith-Garvin, J. E., Wülfing, C., Rittinger, K., Tybulewicz, V. L. J. & Carter, T., 2012, In : Journal of Cell Science.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)
2011

Itk controls the spatiotemporal organization of T cell activation

Singleton, K. L., Gosh, M., Dandekar, R. D., Au-Yeung, B. B., Ksionda, O., Tybulewicz, V. L. J., Altman, A., Fowell, D. J. & Wülfing, C., 4 Oct 2011, In : Science Signaling. 4, 193, ra66.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Phosphatidylinositol (4,5) bisphosphate controls T cell activation by regulating T cell rigidity and organization

Sun, Y., Dandekar, R. D., Mao, Y. S., Yin, H. L. & Wülfing, C., 2011, In : PLoS ONE. 6, 11, e27227.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse

DeFord-Watts, L. M., Dougall, D. S., Belkaya, S., Johnson, B. A., Eitson, J. L., Roybal, K. T., Barylko, B., Albanesi, J. P., Wülfing, C. & van Oers, N. S. C., 2011, In : Journal of Immunology. 186, 12, p. 6839-47 9 p.

Research output: Contribution to journalArticle (Academic Journal)

47 Citations (Scopus)
2010

Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function

Roybal, K. T. & Wülfing, C., 2010, In : Science Signaling. 3, 132, p. pe24

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42

Sinai, P., Nguyen, C., Schatzle, J. D. & Wülfing, C., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 26, p. 11912-7 6 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2009

Spatiotemporal patterning during T cell activation is highly diverse

Singleton, K. L., Roybal, K. T., Sun, Y., Fu, G., Gascoigne, N. R. J., van Oers, N. S. C. & Wülfing, C., 7 Apr 2009, In : Science Signaling. 2, 65, ra15.

Research output: Contribution to journalArticle (Academic Journal)

63 Citations (Scopus)

The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions

Deford-Watts, L. M., Tassin, T. C., Becker, A. M., Medeiros, J. J., Albanesi, J. P., Love, P. E., Wülfing, C. & van Oers, N. S. C., 2009, In : Journal of Immunology. 183, 2, p. 1055-64 10 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)