Photo of Claire L Williams

Miss Claire L Williams

BSc(WEngland)Hons)

20182019

Research output per year

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Personal profile

Research interests

I am currently undertaking a three-year Diabetes UK funded PhD Studentship into Type 1 Diabetes. My project primarily focuses on one of the four major autoantibody biomarkers that has been used to identify individuals at risk of the disease. The protein ZnT8 and subsequent autoantibodies, ZnT8A have been shown to be in ~70+% of newly-diagnosed individuals but ZnT8A can also remain in circulating blood for many years in individuals that have not progressed to disease. My project aims to work out what areas of the ZnT8A protein the autoantibodies are directed to, confirm the expression of ZnT8 as part of historically used ICA staining in pancreatic sections and investigate whether ZnT8 and ZnT8A could help identify some mechanisms some individuals appear to have that regulate the autoimmune response in Type 1 Diabetes and delays disease onset.

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Research Output

  • 2 Article (Academic Journal)
  • 1 Review article (Academic Journal)

What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?

Williams, C. L. & Long, A. E., 23 Aug 2019, In : Diabetologia. 62, 11, 8 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
  • 1 Citation (Scopus)
    123 Downloads (Pure)

    A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study

    Kozhakhmetova, A., Wyatt, R. C., Caygill, C., Williams, C. L., Long, A. E., Chandler, K., Aitken, R. J., Wenzlau, J. M., Davidson, H. W., Gillespie, K. M. & Williams, A. J. K., 1 Jun 2018, In : Clinical and Experimental Immunology. 192, 3, p. 251-258 8 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 11 Citations (Scopus)
    209 Downloads (Pure)

    Assessment and Management of Anti-insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome

    Church, D., Cardoso, L., Kay, R. G., Williams, C. L., Freudenthal, B., Clarke, C., Harris, J., Moorthy, M., Karra, E., Gribble, F. M., Reimann, F., Burling, K., Williams, A. J. K., Munir, A., Jones, T. H., Führer, D., Moeller, L. C., Cohen, M., Khoo, B., Halsall, D. & 1 others, Semple, R., Oct 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 10, p. 3845-3855 11 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 2 Citations (Scopus)
    203 Downloads (Pure)

    Activities

    • 1 Participation in conference
    • 1 Participation in workshop, seminar, course

    L&R Postgraduate Seminar Series 2019

    Hannah M Tayler (Chair), , Ahmad Alghamdi (Speaker), , Jonathan Evans (Speaker), , Danya Bakhbakhi (Speaker), , Steven Bailey (Speaker), , Elliott Hibbs (Speaker), , Yulia Liem (Speaker), , Jamie Robinson (Speaker), , James Selwood (Speaker), , Flossie Carpenter (Speaker), , Steven Walker (Speaker), , Alfie Wearn (Speaker), , Esther Saunders-Jennings (Speaker), , Yunfei Li (Speaker), , Abdullah Alqasem (Speaker), , Reham Mashat (Speaker), , Richard Davis (Speaker), , Claire Williams (Speaker), , Anna Bibby (Speaker), , Carlos Muñoz-Neira (Speaker), , Georgina Kingshott (Speaker), , Amy Howell (Speaker), , Rob MacLachlan (Speaker), & Emily Hotton (Speaker)

    1 Jan 201931 Dec 2019

    Activity: Participating in or organising an event typesParticipation in conference

    File

    L&R Postgraduate Seminar Series 2018

    Hannah M Tayler (Chair), , Arti Bhimjiyani (Speaker), , Anna Bibby (Speaker), , Steven Walker (Speaker), , Alan Uren (Speaker), , Noura Al Mulhim (Speaker), , Yunfei Li (Speaker), , Reham Mashat (Speaker), , Claire Williams (Speaker), , Georgina Kingshott (Speaker), , Mai Mwafy (Speaker), , Jose Gerardo-Aviles (Speaker), , Chara Triantafyllou (Speaker), , Alfie Wearn (Speaker), , Flossie Carpenter (Speaker), , Georgina Mortimer (Speaker), , Amy Howell (Speaker), , Carlos Muñoz-Neira (Speaker), & Tanya Cerajewska (Speaker)

    1 May 201831 Dec 2018

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course