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Personal profile

Research interests

Claire Perks completed her PhD from the University of Bristol in 1995, in which she studied ‘The Role of the IGF axis in the Ovary’ in relation to fertility. She then continued these studies as a Postdoctoral Research Scientist at The Royal Veterinary College, University of London before joining Professor Jeff Holly’s team as a Research Associate in the University of Bristol, Department of Surgery. Claire is currently a Reader in Tumour Cell Biology in the University of Bristol IGF & Metabolic Endocrinology group based at Southmead Hospital. Claire's primary interests are in the role of the IGF axis in relation to breast and prostate cancer. The IGF axis has been conserved throughout evolution to mediate the effects of nutrition on growth and has been implicated in the epithelial cancers associated with a Western diet. Claire is particularly interested in studying the interactions of key dietary factors with the IGF axis and how this may influence breast and prostate cancer progression.

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Research Output

  • 68 Article (Academic Journal)
  • 1 Chapter in a book
  • 1 Review article (Academic Journal)

BCATC modulates crosstalk between the PIK/AKT and the RAS/ERK pathway regulating proliferation in triple negative breast cancer

Shafei, M., Forshaw, T., Davis, J., Flemban, A., Qualtrough, J. D., Dean, S., Perks, C. M., Dong, M., Newman, R. & Conway, M., 14 Apr 2020, (Accepted/In press) In : Oncotarget.

Research output: Contribution to journalArticle (Academic Journal)

  • IGF-1 and Hyperglycaemia-induced FOXA1 and IGFBP-2 affect epithelial to mesenchymal transition in prostate epithelial cells

    Mansor, R., Holly, J. M. P., Barker, R. M., Biernacka, K. M., Zielinska, H. A., Koupparis, A. J., Rowe, E., Oxley, J., Sewell, A., Martin, R. M., Lane, J. A., Hackshaw-McGeagh, L. & Perks, C. M., 30 Jun 2020, In : Oncotarget. 11, p. 2543-2559 17 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 16 Downloads (Pure)

    Mini review: Opposing pathologies in cancer and Alzheimer's disease: Does the PI3K/Akt pathway provide clues?

    Barker, RM., Holly, J. M. P., Biernacka, K. M., Allen-Birt, S. J. A. & Perks, C. M., 23 Jun 2020, In : Frontiers in Endocrinology. p. 1-9 9 p., 403.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 15 Downloads (Pure)