Projects per year
Personal profile
Research interests
I have spent many years researching development and differentiation - how molecules and cells become organised, especially during root development in Arabidopsis seedlings. Topics have included the role of auxin in plant cell growth, and the subcellular networks that drive tip growth in root hair cells. For more on these topics please visit our wiki. We are now applying our knowledge of plant roots to discover how roots prevent soil erosion, bearing in mind that human activity has already eroded a quarter of the vegetated land on Earth. We are also discovering how patterns of molecules and cells might be controlled. As a member of BrisSynBio and Bristol Director of the SynBio CDT I am also involved in research aimed at making the engineering of plants and cell populations more reliable.
Lay summary of research interests
We know that life is the product of complicated physical and chemical interactions between molecules, but how do these produce growth, and how is this growth controlled so that it happens at precisely the right times and in the right places? We are working to answer these questions using plants and microbes because it is easier, technically and ethically, to do powerful, informative experiments with these organisms than with animals. We often identify new molecules that are important for growth in many organisms. We are also finding out how interactions between molecules control growth. Most recently we have receved funding from the Leverhulme Trust to investigate how plant roots prevent soil erosion. This is potentially very important as we have already eroded at least a quarter of the vegetated land on earth. Our results are potentially relevant to a wide range of applications from agriculture to human health and we are exploring potential agricultural applications.
iGEM
I co-founded the University of Bristol iGEM team with Mario Di Bernardo. Each spring a joint undergraduate and postgraduate Synthetic Biology workshop is held in preparation for iGEM. The team then works through the summer on a competition entry for the international Genetically Engineered Machine (iGEM) competition at Massachusetts Institute of Technology (MIT). So far we have been very successful, winning the Best Model prize in 2008 and 2009, gold medals in 2009 and 2010, and winning Best Food or Energy Project and third place overall in 2010. Projects have included engineering bacteria to work as a team Bristol iGEM 2008, Bristol iGEM 2009, and beads containing fluorescent bacteria that are designed to make agriculture less environmentally damaging Bristol iGEM 2010.
Network Evolution
- Interested in how networks evolve?
- Want to understand how the structure of a network affects its function?
- Try our dynamical network simulator at http://www.netevo.org
Structured keywords and research groupings
- Cabot Institute Food Security Research
- Cabot Institute Environmental Change Research
- Cabot Institute Natural Hazards and Disasters Research
- Cabot Institute Water Research
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- 3 Similar Profiles
Network
Projects
- 6 Finished
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REGULATION OF ARABIDOPSIS GROWTH & DEVELOPMENT BY THE S-ACYLTRANSFERASE TIP1
1/01/06 → 1/01/09
Project: Research
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Research output
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Harnessing the central dogma for stringent multi-level control of gene expression
Greco, F. V., Pandi, A., Erb, T. J., Grierson, C. S. & Gorochowski, T. E., 18 Feb 2021, (Accepted/In press) In: Nature Communications.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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ChipSeg: an automatic tool to segment bacterial and mammalian cells cultured in microfluidic devices
De Cesare, I., Zamora Chimal, C. G., Postiglione, L., Khazim, M., Pedone, E., Shannon, B. M., Fiore, G., Perrino, G., Napolitano, S., di Bernardo, D., Savery, N. J., Grierson, C. S., Di Bernardo, M. & Marucci, L., 20 Nov 2020, (Accepted/In press) In: ACS Omega.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology
Marucci, L., Barberis, M., Karr, J., Ray, O., Race, P. R., de Souza Andrade, M., Grierson, C. S., Hoffmann, S. A., Landon, S., Rech, E., Rees-Garbutt, J. P., Seabrook, R., Shaw, W. & Woods, C. J., 7 Aug 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 11 p., 942.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile
Datasets
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A Centrifuge-Based Method for Identifying Novel Genetic Traits That Affect Root-Substrate Adhesion in Arabidopsis thaliana
Grierson, C. S. (Creator), Eldridge, B. M. (Creator) & Larson, E. R. (Creator), University of Bristol, 10 Feb 2021
DOI: 10.5523/bris.21loiw3fpw372g99l93meaja1, http://data.bris.ac.uk/data/dataset/21loiw3fpw372g99l93meaja1
Dataset
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Data from whole-cell modelling (12-2019)
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 6 Dec 2019
DOI: 10.5523/bris.1jj0fszzrx9qf2ldcz654qp454, http://data.bris.ac.uk/data/dataset/1jj0fszzrx9qf2ldcz654qp454
Dataset
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Data from Understanding metabolic behaviour whole-cell model
Marucci, L. (Creator), Grierson, C. S. (Creator), Chalkley, O. (Creator), Rees-Garbutt, J. P. (Creator) & Landon, S. (Creator), University of Bristol, 20 Aug 2020
DOI: 10.5523/bris.3u1v7dy42fk332watjl81m13y0, http://data.bris.ac.uk/data/dataset/3u1v7dy42fk332watjl81m13y0
Dataset
Activities
- 1 Editorial activity
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Current Opinion in Plant Biology (Journal)
Claire S Grierson (Editor)
2010Activity: Publication peer-review and editorial work types › Editorial activity