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My research interests are the neural and cellular substrates of learning and memory processes in animals. I am specifically interested in the distinct contributions the perirhinal and prefrontal cortices and the hippocampal formation make to recognition memory processing.
The work conducted by my research group has involved the use of a number of complementary behavioural, pharmacological and molecular techniques to examine the neural basis of recognition memory. In earlier experiments we revealed the differential roles played by the perirhinal cortex, hippocampus and prefrontal cortex in specific components of recognition memory, namely familiairity discrimination (our ability to tell if a stimulus such as an object, is familiar or novel); object-in-place associaitive recognition memory (our ability to tell if an object has changed its location); recency recognition memory (our ability to judge how recently an object has been encountered) .
The research uses a multidisciplinary approach incorporating molecular and cellular techniques with behavioural analysis of recognition memory. Most recently my lab have used pharmacogenetics and optogenetics to manipulate specific neural pathways between defined brain regions during specific phases of memory to uncover the nature of information processing across brain wide memory circuits.
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- 5 Finished
1/05/19 → 30/06/21
1/09/17 → 31/08/22
4/04/11 → 4/04/14
A critical role for long-term potentiation mechanisms in the maintenance of object recognition memory in perirhinal cortex revealed by the infusion of zeta inhibitory pseudosubstrateOutram, A. R., Brown, M. W., Warburton, C. & Barker, G. R. I., 3 Oct 2022, In: Frontiers in Behavioral Neuroscience. 16, 11 p., 970291.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile3 Citations (Scopus)16 Downloads (Pure)
Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and HippocampusBanks, P. J., Warburton, C. & Bashir, Z. I., 14 Apr 2021, In: Cerebral cortex communications. 2, 2, p. 1-16 16 p., tgab029.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile34 Downloads (Pure)
Kolaric, K., Strauch, C., Li, Y., Woods, S. M., Lopes, M. A., Sivarajah, N., Teixeira, C. M., Lerch, J., Frankland, P. W., Henkelman, M., Bortolotto, Z. A., Warburton, C., Bashir, Z. I., Vaughan, D. M. & Atan, D., 6 Dec 2021, (Submitted).
Research output: Working paper › Preprint