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Research interests

I have several academic/research interests arising from my background in industry R&D and academic research. I'm interested in polymicrobial biofilms and inter-kingdom interactions between oral bacteria and the fungus Candida albicans, and how virulence and pathogenicity can be modulated by oral bacteria. I'm also interested in modelling infections through use of 3D tissue models (developed and cultured in vitro) and host responses to the biofilm infections. I have a recent interest in using probitoics to selectively modulate virulence in vitro and in vivo.

My current project is working with Streptococcus pneumoniae virulence as part of Ruth Massey's group. We are interested in the genetic and molecular basis for virulence, with particular attention to the pneumolysin (ply) toxin operon, regulation of ply gene and protein expression, and the impact of a novel ply regulator protein ZomB.

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