Dr Darryl J Hill

B.Sc., Ph.D.(Wales)

  • BS8 1TD


Research output per year

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Personal profile

Research interests

Bacterial infections of the respiratory tract which lead to localised or disseminated disease are a considerable health and financial burden globally. Our research focuses on understanding the interplay between bacteria (mainly colonisers of the respiratory tract) and their human host during colonisation and progression of disease. By understanding key mechanisms used by bacteria to interact with human cells and tissues therapeutic targets can be identified.

Specific interests

  • Molecular basis of receptor targeting by mucosal pathogens which colonise the human nasopharynx and oropharynx. Principally studies focus on Neisseria meningitidis, Moraxella catarrhalis and Haemophilus influenzae.
  • Interactions of Neisseria meningitidis with serum components.
  • Epithelial cell responses to neisserial infection.
  • Bacterial interplay during adhesion to human respiratory epithelia.
  • Structure and function analyses of Moraxella catarrhalis surface proteins.
  • Bacterial-stem cell interactions in osteomyelitis.

Current collaborators

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Research Output

  • 21 Article (Academic Journal)
  • 3 Chapter in a book
Open Access
  • 9 Downloads (Pure)

    Agent-based modelling study of antimicrobial resistant Neisseria gonorrhoeae transmission in men who have sex with men: towards individualised diagnosis and treatment

    Zienkiewicz, A., Verschueren van Rees, N., Homer, M., Ong, J., Christensen, H., Hill, D., Looker, K., Horner, P. J., Hughes, G. & Turner, K., 3 Sep 2019, In : Sexual Health. 9 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 1 Citation (Scopus)
    103 Downloads (Pure)

    Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF

    Brewer, M. L., Dymock, D., Brady, R. L., Singer, B. B., Virji, M. & Hill, D. J., Jan 2019, In : Journal of Oral Microbiology . 11, 1, 16 p., 1565043 .

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 8 Citations (Scopus)
    392 Downloads (Pure)

    Supervised Work

    A mouse model of haemoplasma infection, in vitro cultivation of haemoplasmas and steps towards better diagnosis of and vaccination against haemoplasmosis

    Author: Filler, S., 23 Jan 2020

    Supervisor: Helps, C. (Supervisor), Bailey, M. (Supervisor), Tasker, S. (Supervisor), Hill, D. (Supervisor) & Knowles, T. G. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)


    Investigating Fusobacterium pathogenesis using molecular and genomic methods to inform vaccine design

    Author: Brewer, M. L., 1 Oct 2019

    Supervisor: Hill, D. (Supervisor) & Brady, L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)


    The Impact of Sialidases on the Urogenital Tract

    Author: Oswin, H., 19 Mar 2019

    Supervisor: Hill, D. (Supervisor) & Horner, P. (External person) (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)