Projects per year
Personal profile
Research interests
- Mechanisms of innate immune cell activation and tissue damage in ocular inflammatory and neovascular conditions.
- Control of immune responses to promote/restore tissue homeostasis and function in the eye.
- In vivo ocular imaging, using Topical Endoscopic Fundal Imaging (TEFI), Fundal Fluorescein Angiography (FA) and Optical Coherence Tomography (OCT) platforms.
- Preclinical testing of novel therapeutic approaches using ocular disease models.
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Projects
- 1 Active
Research output
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Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2
Hu, X., Zou, Y., Copland, D. A., Schewitz-Bowers, L. P., Li, Y., Lait, P. J. P., Stimpson, M., Zhang, Z., Guo, S., Liang, J., Chen, T., Li, J. J., Yuan, S., Li, S., Zhou, P., Liu, Y., Dick, A. D., Wen, X., Lee, R. W. J. & Wei, L., 1 Dec 2022, In: EBioMedicine. 86, 104333.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile4 Citations (Scopus)10 Downloads (Pure) -
Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration
Lee, K. S., Lin, S., Copland, D. A., Dick, A. D. & Liu, J., 22 Jan 2021, In: Journal of Neuroinflammation. 18, 1, 32.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access48 Citations (Scopus) -
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses
Chan, Y. K., Wang, S. K., Chu, C. J., Copland, D. A., Letizia, A. J., Costa Verdera, H., Chiang, J. J., Sethi, M., Wang, M. K., Neidermyer, W. J., Chan, Y., Lim, E. T., Graveline, A. R., Sanchez, M., Boyd, R. F., Vihtelic, T. S., Inciong, R. G. C. O., Slain, J. M., Alphonse, P. J., Xue, Y., & 21 others, 10 Feb 2021, In: Science Translational Medicine. 13, 580, eabd3438.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile80 Citations (Scopus)250 Downloads (Pure)