Dr David A Hughes

Search results

• 2021

  Dietary intake of vitamin A, lung function, and incident asthma in childhood

  Talaei, M., Hughes, D. A., Mahmoud, O., Emmett, P. M., Granell, R., Guerra, S. & Shaheen, S. O., 1 Apr 2021, In: The European respiratory journal.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

• Frequency and phenotypic expression in childhood and early adulthood of loss of function mutations in the Melanocortin 4 Receptor in a UK birth cohort

  Wade, K. H., Lam, B. Y. H., Melvin, A., Pan, W., Corbin, L. J., Hughes, D. A., Rainbow, K., Chen, J. H., Duckett, K., Liu, X., Mokrosińsk, J., Mörseburg, A., Neaves, S., Williamson, A., Zhang, C., Farooqi, I. S., Yeo, G. S. H., Timpson, N. J. & O'Rahilly, S., 3 Mar 2021, (Accepted/In press) In: Nature Medicine.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
• 2020

  Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women

  Lee, M., McMahon, G., Karhunen, V., Wade, K. H., Corbin, L. J., Hughes, D. A., Davey Smith, G., Lawlor, D. A., Jarvelin, M-R. & Timpson, N. J., 15 Jun 2020, In: Human Molecular Genetics. 29, 12, p. 9 2098 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Glycosuria
  • Genome-Wide Association Study
  • Pregnancy
  • Chromosomes, Human, Pair 16
  • Mothers
  33 Downloads (Pure)

• Expanding the Geographic Characterisation of Epstein-Barr Virus Variation through Gene-Based Approaches

  Telford, M., Hughes, D. A., Juan, D., Stoneking, M., Navarro, A. & Santpere, G., 29 Oct 2020, In: Microorganisms. 8, 11

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

• Genome-wide associations of human gut microbiome variation and implications for causal inference analyses

  Hughes, D. A., Bacigalupe, R., Wang, J., Rühlemann, M., Tito, R., Falony, G., Joossens, M., Vieira-Silva, S., Henckaerts, L., Rymenans, L., Verspecht, C., Ring, S. M., Franke, A., Wade, K. H., Timpson, N. J. & Raes, J., 22 Jun 2020, In: Nature Microbiology. 5, p. 1079–1087 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Microbiota
  • Gastrointestinal Microbiome
  • Genome
  • Bifidobacterium
  • Genotype
  64 Downloads (Pure)

• Maximizing the acquisition of unique reads in non-invasive capture sequencing experiments

  Fontsere, C., Alvarez-Estape, M., Lester, J., Arandjelovic, M., Kuhlwilm, M., Dieguez, P., Agbor, A., Angedakin, S., Ayimisin, E. A., Bessone, M., Brazzola, G., Deschner, T., Eno-Nku, M., Granjon, A-C., Head, J., Kadam, P., Kalan, A. K., Kambi, M., Langergraber, K., Lapuente, J. & 10 others, Maretti, G., Piel, A., Robbins, M. M., Stewart, F., Vergnes, V., Wittig, R. M., Kühl, H. S., Marques-Bonet, T., Hughes, D. A. & Lizano, E., 19 Dec 2020, In: Molecular Ecology Resources. 17 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • DNA
  • library
  • Libraries
  • experiment
  • sampling
  22 Downloads (Pure)

• Metabolic characterisation of disturbances in the APOC3/triglyceride-rich lipoprotein pathway through sample-based recall by genotype

  Corbin, L., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Ratcliffe, A., Jankevics, A., Weber, R. J. M., Groom, A., Dunn, W. B. & Timpson, N. J., 3 Jun 2020, In: Metabolomics. (2020) 16, 69, 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Apolipoprotein C-III
  • Metabolites
  • Lipoproteins
  • Triglycerides
  • Genotype
  54 Downloads (Pure)

• Targeted conservation genetics of the endangered chimpanzee

  Frandsen, P., Fontsere, C., Nielsen, S. V., Hanghøj, K., Castejon-Fernandez, N., Lizano, E., Hughes, D., Hernandez-Rodriguez, J., Korneliussen, T. S., Carlsen, F., Siegismund, H. R., Mailund, T., Marques-Bonet, T. & Hvilsom, C., 28 Apr 2020, In: Heredity. 2020, 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Pan troglodytes
  • Endangered Species
  • Population
  • Breeding
  • Pets
  48 Downloads (Pure)
• 2019

  A roadmap for high-throughput sequencing studies of wild animal populations using noninvasive samples and hybridization capture

  White, L. C., Fontsere, C., Lizano, E., Hughes, D. A., Angedakin, S., Arandjelovic, M., Granjon, A. C., Hans, J. B., Lester, J. D., Rabanus-Wallace, M. T., Rowney, C., Städele, V., Marques-Bonet, T., Langergraber, K. E. & Vigilant, L., 1 May 2019, In: Molecular Ecology Resources. 19, 3, p. 609-622 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • wild animal
  • animal population
  • Wild Animals
  • wild animals
  • DNA
  11 Citations (Scopus)

• Assessment of reproducibility and biological variability of fasting and postprandial plasma metabolite concentrations using ¹H NMR spectroscopy

  Li-Gao, R., Hughes, D. A., le Cessie, S., de Mutsert, R., den Heijer, M., Rosendaal, F. R., Willems van Dijk, K., Timpson, N. J. & Mook-Kanamori, D. O., 20 Jun 2019, In: PLoS ONE. 14, 6, 14 p., e0218549.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Nuclear magnetic resonance spectroscopy
  • Metabolites
  • Proton Magnetic Resonance Spectroscopy
  • reproducibility
  • Spectrum Analysis
  6 Citations (Scopus)

  133 Downloads (Pure)

• Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease

  Rodríguez, J. A., Farré, X., Muntané, G., Marigorta, U. M., Hughes, D. A., Spataro, N., Bosch, E. & Navarro, A., 1 Jul 2019, In: Nature Ecology and Evolution. 3, 7, p. 994-995 2 p.

  Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review
  2 Citations (Scopus)
• 2018

  Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis

  Muntané, G., Farré, X., Rodríguez, J. A., Pegueroles, C., Hughes, D. A., de Magalhães, J. P., Gabaldón, T. & Navarro, A., Aug 2018, In: Molecular Biology and Evolution. 35, 8, p. 1990-2004 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • primate
  • Biological Phenomena
  • biological processes
  • genome
  • Primates
  22 Citations (Scopus)

  241 Downloads (Pure)

• Coronary Artery Disease, Genetic Risk and the Metabolome in Young Individuals

  Battram, T., Hoskins, L., Hughes, D., Kettunen, J., Ring, S., Davey Smith, G., Timpson, N. & Ford, D., 12 Sep 2018, In: Wellcome Open Research. 3, 13 p., 114.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Metabolome
  • Coronary Artery Disease
  • Lipoproteins
  • LDL Lipoproteins
  • Magnetic Resonance Spectroscopy
  3 Citations (Scopus)

  332 Downloads (Pure)

• Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

  Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K. H., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O'Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C. N. A., Pearson, E. R., Scott, R. A., Van Heel, D. A. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In: Nature Communications. 9, 1, 11 p., 711.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • inference
  • catalogs
  • resources
  • Genotype
  • Catalogs
  21 Citations (Scopus)

  273 Downloads (Pure)

• Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

  Wang, J., Kurilshikov, A., Radjabzadeh, D., Turpin, W., Croitoru, K., Bonder, M. J., Jackson, M. A., Medina-Gomez, C., Frost, F., Homuth, G., Rühlemann, M., Hughes, D., Kim, H. N., Spector, T. D., Bell, J. T., Steves, C. J., Timpson, N., Franke, A., Wijmenga, C., Meyer, K. & 6 others, Kacprowski, T., Franke, L., Paterson, A. D., Raes, J., Kraaij, R. & Zhernakova, A., 8 Jun 2018, In: Microbiome. 6, 1, 7 p., 101.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Human Genome
  • Microbiota
  • Meta-Analysis
  • Genome-Wide Association Study
  • Genome
  39 Citations (Scopus)

  360 Downloads (Pure)

• The impact of endogenous content, replicates and pooling on genome capture from faecal samples

  Hernandez-Rodriguez, J., Arandjelovic, M., Lester, J., de Filippo, C., Weihmann, A., Meyer, M., Angedakin, S., Casals, F., Navarro, A., Vigilant, L., Kühl, H. S., Langergraber, K., Boesch, C., Hughes, D. & Marques-Bonet, T., 25 Mar 2018, In: Molecular Ecology Resources. 18, 2, p. 319-333 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Recreational Parks
  • genome
  • library
  • Libraries
  • Pan troglodytes
  12 Citations (Scopus)

  181 Downloads (Pure)
• 2017

  Antagonistic pleiotropy and mutation accumulation influence human senescence and disease

  Rodríguez, J. A., Marigorta, U. M., Hughes, D. A., Spataro, N., Bosch, E. & Navarro, A., 30 Jan 2017, In: Nature Ecology and Evolution. 1, 3, p. 55

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Mutation Accumulation
  • Late Onset Disorders
  • Genetic Selection
  • Genome-Wide Association Study
  • Gene Frequency

• BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

  Kertes, D. A., Bhatt, S. S., Kamin, H. S., Hughes, D. A., Rodney, N. C. & Mulligan, C. J., 30 Jun 2017, In: Clinical Epigenetics. 9, 12 p., 68.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Maternal Exposure
  • Armed Conflicts
  • Brain-Derived Neurotrophic Factor
  • Methylation
  • Newborn Infant
  34 Citations (Scopus)

  221 Downloads (Pure)

• DNA methylation of methylation complex genes in relation to stress and genome-wide methylation in mother-newborn dyads

  Clukay, C. J., Hughes, D. A., Rodney, N. C., Kertes, D. A. & Mulligan, C. J., 13 Oct 2017, In: American Journal of Physical Anthropology. 165, 1, p. 173-182 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • DNA Methylation
  • dyad
  • Methylation
  • Newborn Infant
  • Genome
• 2016

  Prenatal Maternal Stress Predicts Methylation of Genes Regulating the Hypothalamic-Pituitary-Adrenocortical System in Mothers and Newborns in the Democratic Republic of Congo

  Kertes, D. A., Kamin, H. S., Hughes, D. A., Rodney, N. C., Bhatt, S. & Mulligan, C. J., 28 Jan 2016, In: Child Development. 87, 1, p. 61-72 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Democratic Republic of the Congo
  • Armed Conflicts
  • Methylation
  • Newborn Infant
  • Birth Weight
• 2015

  Evaluating intra- and inter-individual variation in the human placental transcriptome

  Hughes, D. A., Kircher, M., He, Z., Guo, S., Fairbrother, G. L., Moreno, C. S., Khaitovich, P. & Stoneking, M., 19 Mar 2015, In: Genome Biology. 16, p. 54

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • individual variation
  • gene expression
  • Transcriptome
  • transcriptome
  • Gene Expression
  30 Citations (Scopus)
• 2012

  Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight

  Mulligan, C. J., D'Errico, N. C., Stees, J. & Hughes, D. A., Aug 2012, In: Epigenetics. 7, 8, p. 853-7 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Birth Weight
  • Methylation
  • Newborn Infant
  • Mothers
  • Democratic Republic of the Congo
  180 Citations (Scopus)
• 2011

  Genetic and neural dissociation of individual responses to emotional expressions in human infants

  Grossmann, T., Johnson, M. H., Vaish, A., Hughes, D. A., Quinque, D., Stoneking, M. & Friederici, A. D., Jan 2011, In: Developmental Cognitive Neuroscience. 1, 1, p. 57-66 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Catechol O-Methyltransferase
  • Temperament
  • Facial Expression
  • Brain
  • Laughter
  37 Citations (Scopus)

• The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups

  Delfin, F., Salvador, J. M., Calacal, G. C., Perdigon, H. B., Tabbada, K. A., Villamor, L. P., Halos, S. C., Gunnarsdóttir, E., Myles, S., Hughes, D. A., Xu, S., Jin, L., Lao, O., Kayser, M., Hurles, M. E., Stoneking, M. & De Ungria, M. C. A., Feb 2011, In: European Journal of Human Genetics. 19, 2, p. 224-30 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Philippines
  • Y Chromosome
  • Genetic Heterogeneity
  • Chromosomes, Human, Y
  • Genetic Drift
  53 Citations (Scopus)
• 2009

  Increased constraints on MC4R during primate and human evolution

  Hughes, D. A., Hinney, A., Brumm, H., Wermter, A-K., Biebermann, H., Hebebrand, J. & Stoneking, M., Jan 2009, In: Human Genetics. 124, 6, p. 633-47 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Receptor, Melanocortin, Type 4
  • Primates
  • Pan troglodytes
  • Mutation
  • human MC4R protein
  23 Citations (Scopus)

• Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis

  Hughes, D. A., Jastroch, M., Stoneking, M. & Klingenspor, M., 7 Jan 2009, In: BMC Evolutionary Biology. 9, p. 4

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • heat production
  • history
  • protein
  • proteins
  • brown adipose tissue
  50 Citations (Scopus)

• Natural selection and the molecular basis of electrophoretic variation at the coagulation F13B locus

  Ryan, A. W., Hughes, D. A., Tang, K., Kelleher, D. P., Ryan, T., McManus, R. & Stoneking, M., Feb 2009, In: European Journal of Human Genetics. 17, 2, p. 219-27 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Genetic Selection
  • Alleles
  • Exons
  • Coronary Artery Disease
  • Genetic Drift
  18 Citations (Scopus)

• Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness

  Hillmer, A. M., Freudenberg, J., Myles, S., Herms, S., Tang, K., Hughes, D. A., Brockschmidt, F. F., Ruan, Y., Stoneking, M. & Nöthen, M. M., Aug 2009, In: Human Genetics. 126, 2, p. 255-64 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Xedar Receptor
  • human AR protein
  • Alopecia
  • Haplotypes
  • Androgen Receptors
  29 Citations (Scopus)
• 2008

  An ancient look at UCP1

  Klingenspor, M., Fromme, T., Hughes, D. A., Manzke, L., Polymeropoulos, E., Riemann, T., Trzcionka, M., Hirschberg, V. & Jastroch, M., 9 Apr 2008, In: Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777, 7-8, p. 637-41 5 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  • Uncoupling Protein 1
  • Thermogenesis
  • Brown Adipose Tissue
  • Eutheria
  • Mammals

• Parallel selection on TRPV6 in human populations

  Hughes, D. A., Tang, K., Strotmann, R., Schöneberg, T., Prenen, J., Nilius, B. & Stoneking, M., 27 Feb 2008, In: PLoS ONE. 3, 2, p. e1686

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • human population
  • Electrophysiology
  • Haplotypes
  • Cloning
  • haplotypes
  35 Citations (Scopus)

• Positive selection in East Asians for an EDAR allele that enhances NF-kappaB activation

  Bryk, J., Hardouin, E., Pugach, I., Hughes, D., Strotmann, R., Stoneking, M. & Myles, S., 21 May 2008, In: PLoS ONE. 3, 5, p. e2209

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • transcription factor NF-kappa B
  • NF-kappa B
  • Genes
  • Chemical activation
  • Alleles
  70 Citations (Scopus)
• 2004

  Effect of a beta-3 agonist on food intake in two strains of rats that differ in susceptibility to obesity

  White, C. L., Ishihara, Y., Dotson, T. L., Hughes, D. A., Bray, G. A. & York, D. A., 15 Sep 2004, In: Physiology and Behavior. 82, 2-3, p. 489-96 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate
  • Eating
  • Obesity
  • Fats
  • Serum
  19 Citations (Scopus)

• Humans

  Hughes, D. A., Cordaux, R. & Stoneking, M., 25 May 2004, In: Current Biology. 14, 10, p. R367-9

  Research output: Contribution to journal › Article (Academic Journal)
  2 Citations (Scopus)

• Quantitative PCR for DNA identification based on genome-specific interspersed repetitive elements

  Walker, J. A., Hughes, D. A., Hedges, D. J., Anders, B. A., Laborde, M. E., Shewale, J., Sinha, S. K. & Batzer, M. A., Mar 2004, In: Genomics. 83, 3, p. 518-27 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Interspersed Repetitive Sequences
  • Genome
  • Polymerase Chain Reaction
  • DNA
  • Birds
  51 Citations (Scopus)
• 2003

  Quantitative intra-short interspersed element PCR for species-specific DNA identification

  Walker, J. A., Hughes, D. A., Anders, B. A., Shewale, J., Sinha, S. K. & Batzer, M. A., 15 May 2003, In: Analytical Biochemistry. 316, 2, p. 259-69 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Polymerase Chain Reaction
  • Assays
  • DNA
  • Chickens
  • Cattle
  84 Citations (Scopus)
• 2002

  Comparative study of enterostatin sequence in five rat strains and enterostatin binding proteins in rat and chicken serum

  Wu, Y. J., Hughes, D., Lin, L., Braymer, D. H. & York, D. A., Mar 2002, In: Peptides. 23, 3, p. 537-44 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • procolipase
  • procolipase activation peptide
  • Rats
  • Chickens
  • Carrier Proteins
  13 Citations (Scopus)