Projects per year
I am primarily interested in virus host cell interactions with an emphasis on respiratory viruses, in particular adenovirus, but also coronaviruses, respiratory syncytial virus, influenza and Hendra virus. I have been looking at how these viruses interact with the host cell using state of the art techniques including laser confocal microscopy, high throughput quantitative mass spectrometry and Deep Sequencing (or Next Generation Sequencing) of virus infected cells. In collaboration with Prof Davidson here at Bristol we also apply these techniques to the study of Dengue virus.
Most recently we have become very interested in the study of novel zoonotic agents such as SARS CoV-2, Hendra, MERS CoV and Ebola. We are at the forefront of developing novel intergrated high throughput methods to study these very dangerous viruses in their natural hosts (bats) to try to understand why they are apparently harmless to their natural host but highly lethal in humans.
In addition, we also use these high throughput approaches to study recombinant gene therapy systems (especially adenovirus based ones). This includes an emphasis on the molecular basis of oncolytic or cancer killing adenoviruses.
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- 4 Finished
SARS-CoV-2 genetic diversity and stability in the presence of neutralizing antibodies and antivirals
2/11/20 → 1/05/21
4/01/16 → 3/01/20
- 52 Article (Academic Journal)
Evans, V. C., Barker, G., Heesom, K. J., Fan, J., Bessant, C. & Matthews, D. A., Dec 2012, In: Nature Methods. 9, 12, p. 1207-11 5 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review127 Citations (Scopus)
Nanopore ReCappable sequencing maps SARS-CoV-2 5′ capping sites and provides new insights into the structure of sgRNAsUgolini, C., Mulroney, L., Leger, A., Castelli, M., Criscuolo, E., Kavanagh Williamson, M., Davidson, A. D., Almuqrin, A. M., Giambruno, R., Jain, M., Frige, G., Olsen, H., Tzertzinis, G., Schildkraut, I., Wulf, M. G., Corrêa Jr, I. R., Ettwiller, L., Clementi, N., Clementi, M., Mancini, N., & 5 others, 4 Mar 2022, (E-pub ahead of print) In: Nucleic Acids Research. 50, 6, p. 3475-3489 15 p., gkac144.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile3 Citations (Scopus)28 Downloads (Pure)
- 1 Other