Professor David E Jane

B.A.(Cantab.), Ph.D.(Salf.), M.R.S.C.

  • BS8 1TD

1993 …2020

Research output per year

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Research Output

2020

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Wang, J. X., Irvine, M. W., Burnell, E. S., Sapkota, K., Thatcher, R. J., Li, M., Simorowski, N., Volianskis, A., Collingridge, G. L., Monaghan, D. T., Jane, D. E. & Furukawa, H., 22 Jan 2020, In : Nature Communications. 11, 1, 14 p., 423.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
39 Downloads (Pure)
2019

Assembly and Trafficking of Homomeric and Heteromeric Kainate Receptors with Impaired Ligand Binding Sites

Scholefield, C., Atlason, P., Jane, D. & Molnar, E., 1 Mar 2019, In : Neurochemical Research. 44, 3, p. 585-599 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
261 Downloads (Pure)

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

Irvine, M. W., Fang, G., Sapkota, K., Burnell, E. S., Volianskis, A., Costa, B. M., Culley, G., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., 15 Feb 2019, In : European Journal of Medicinal Chemistry. 164, p. 471-498 28 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
68 Downloads (Pure)

Positive and Negative Allosteric Modulators of N-Methyl- d -aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action

Burnell, E. S., Irvine, M., Fang, G., Sapkota, K., Jane, D. E. & Monaghan, D. T., 10 Jan 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 3-23 21 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
231 Downloads (Pure)

The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries

Lodge, D., Watkins, J. C., Bortolotto, Z., Jane, D. & Volianskis, A., 1 Mar 2019, In : Neurochemical Research. 44, 3, p. 516-530 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
208 Downloads (Pure)

The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators

Sapkota, K., Dore, K., Tang, K., Irvine, M., Fang, G., Burnell, E. S., Malinow, R., Jane, D. E. & Monaghan, D. T., Jan 2019, In : Biochemical Pharmacology. 159, p. 140-153 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
82 Downloads (Pure)
2018

Putative Receptors Underpinning L-Lactate Signalling in Locus Coeruleus

Mosienko, V., Rasooli-Nejad, A., Kishi, K., De Both, M., Jane, D., Huentelman, M., Kasparov, S. & Teschemacher, A., 16 Nov 2018, In : Neuroglia. 1, 2, p. 365-380 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
209 Downloads (Pure)

Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity

Ingram, R., Kang, H. H., Lightman, S., Jane, D., Bortolotto, Z., Collingridge, G., Lodge, D. & Volianskis, A., 6 Jun 2018, In : Neuropharmacology.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
174 Downloads (Pure)
2017

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors

Chopra, D. A., Sapkota, K., Irvine, M. W., Fang, G., Jane, D. E., Monaghan, D. T. & Dravid, S. M., 31 Jul 2017, In : Scientific Reports. 7, 11 p., 6933.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
218 Downloads (Pure)

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives

Sapkota, K., Irvine, M. W., Fang, G., Burnell, E. S., Bannister, N., Volianskis, A., Culley, G. R., Dravid, S. M., Collingridge, G. L., Jane, D. E. & Monaghan, D. T., Oct 2017, In : Neuropharmacology. 125, p. 64-79 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
183 Downloads (Pure)

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

France, G., Fernández-Fernández, D., Burnell, E. S., Irvine, M. W., Monaghan, D. T., Jane, D. E., Bortolotto, Z. A., Collingridge, G. L. & Volianskis, A., Jan 2017, In : Neuropharmacology. 112, A, p. 76-83 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
18 Citations (Scopus)
270 Downloads (Pure)

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site

Safar, F., Hurdiss, E., Erotocritou, M., Greiner, T., Lape, R., Irvine, M. W., Fang, G. Y., Jane, D., Yu, R., Dämgen, M. A., Biggin, P. C. & Sivilotti, L. G., 24 Mar 2017, In : Journal of Biological Chemistry. 292, 12, p. 5031-5042 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
259 Downloads (Pure)
2015

An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo

Wallis, J., Irvine, M., Jane, D., Lodge, D., Collingridge, G. & Bortolotto, Z., 23 Oct 2015, In : Hippocampus. 25, 11, p. 1407-1417 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
199 Downloads (Pure)

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Shoemark, D. K., Williams, C., Fahey, M. S., Watson, J. J., Tyler, S. J., Scoltock, S. J., Ellis, R., Wickendon, E., Burton, A. J., Hemmings, J. L. L., Bailey, C. D., Dawbarn, D., Jane, D. E., Willis, C. L., Sessions, R. B., Allen, S. J. & Crump, M. P., 22 Jan 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 767-777 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
238 Downloads (Pure)

Long-term potentiation and the role of N-methyl-D-aspartate receptors.

Volianskis, A., France, G., Jensen, MS., Bortolotto, Z., Jane, D. & Collingridge, G., 22 Jan 2015, In : Brain Research. 1621, p. 5-16 11 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access

Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators

Irvine, M. W., Fang, G., Eaves, R., Mayo-Martin, M. B., Burnell, E. S., Costa, B. M., Culley, G. R., Volianskis, A., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., Jun 2015, In : Synthesis (Germany). 47, 11, p. 1593-1610 18 p., ss-2014-t0697-op.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
228 Downloads (Pure)
2014

NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation

Park, P., Volianskis, A., Sanderson, T. M., Bortolotto, Z. A., Jane, D. E., Zhuo, M., Kaang, B-K. & Collingridge, G. L., 5 Jan 2014, In : Philosophical Transactions B: Biological Sciences. 369, 1633, p. 20130131

Research output: Contribution to journalReview article (Academic Journal)

Open Access
67 Citations (Scopus)
2013

Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus

Mercier, M. S., Lodge, D., Fang, G., Nicolas, C. S., Collett, V. J., Jane, D. E., Collingridge, G. L. & Bortolotto, Z. A., Apr 2013, In : Neuropharmacology. 67, p. 294-303 10 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.

Volianskis, A., Bannister, N. J., Collett, V. J., Irvine, M. W., Monaghan, DT., Fitzjohn, S. M., Jensen, M. S., Jane, D. E. & Collingridge, G. L., Feb 2013, In : Journal of Physiology. 591, 4, p. 955-972 13 p.

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)

The NMDA receptor as a target for cognitive enhancemant

Collingridge, G. L., Volianskis, A., Bannister, N. J., France, G. M., Hanna, L., Mercier, M. S., Tidball, P. J., Fang, G. Y., Irvine, M. W., Costa, BM., Monaghan, DT., Bortolotto, Z. A., Molnar, E., Lodge, D. & Jane, D. E., Jan 2013, In : Neuropharmacology. 64, p. 13-26 14 p.

Research output: Contribution to journalArticle (Academic Journal)

145 Citations (Scopus)
2012

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors

Irvine, MW., Costa, BM., Volianskis, A., Ceolin, L., Collingridge, GL., Monaghan, DT. & Jane, DE., 2012, In : Neurochemistry International.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation

Sherwood, J. L., Amici, M., Dargan, S. L., Culley, G. R., Fitzjohn, S. M., Jane, D. E., Collingridge, G. L., Lodge, D. & Bortolotto, Z. A., Sep 2012, In : Neurochemistry International. 61, 4, p. 482-489 8 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

Monaghan, D. T., Irvine, M. W., Costa, B. M., Fang, G. & Jane, D. E., Sep 2012, In : Neurochemistry International. 61, 4, p. 581-592 12 p.

Research output: Contribution to journalArticle (Academic Journal)

64 Citations (Scopus)

Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors

Irvine, MW., Costa, BM., Dlaboga, DP., Culley, GR., Hulse, RP., Scholefield, CL., Atlason, PT., Fang, G., Eaves, RJ., Morley, RM., Mayo-Martin, MB., Amici, M., Bortolotto, ZA., Donaldson, LF., Collingridge, GL., Molnar, E., Monaghan, DT. & Jane, DE., 2012, In : Journal of Medicinal Chemistry. 55, 1, p. 327 - 341 15 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Pre- and post-synaptic functions of kainate receptors at glutamate and GABA synapses in the rat entorhinal cortex

Chamberlain, SEL., Jane, DE. & Jones, RSG., 2012, In : Hippocampus. 22, 3, p. 555-576

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid

Costa, B. M., Irvine, MW., Fang, G., Eaves, R. J., Mayo-Martin, M. B., Laube, B., Jane, DE. & Monaghan, D. T., 2012, In : Neuropharmacology. 62, p. 1730-1736

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)
2011

Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists

Alushin, GM., Jane, DE. & Mayer, ML., 2011, In : Neuropharmacology. 60, p. 126 - 134

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Julienne, A., Montagne, A., Orset, C., Lesept, F., Jane, DE., Monaghan, D. T., Maubert, E., Vivien, D. & Ali, C., Oct 2011, In : Molecular Neurodegeneration. 6, p. 68 - 68 1 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

THERAPEUTIC AGENT AND DRUG DESIGN TARGETS: BRAIN NGF RECEPTORS

Allen, S. J., Shoemark, D. K., Hemmings, J. L., Bailey, C. D., Fahey, M. S., Tyler, S. J., Williams, C., Scoltock, S. J., Watson, J. J., Willis, C. L., Crump, M. P., Sessions, R. B. & Jane, D. E., Aug 2011, In : Journal of Psychopharmacology. 25, 8, p. A11-A11 1 p.

Research output: Contribution to journalSpecial issue (Academic Journal)

Towards a model of sporadic Alzheimer’s disease: aiding design of small molecule TrkA agonists

Watson, J., Shoemark, D., Hemmings, J. L., Tyler, S., Fahey, M., Williams, C., Bailey, C., McArdle, C., Caunt, J., Jane, D., Sessions, R., Crump, M., Willis, C. & Allen-Birt, S., 1 Jul 2011, Alzheimer's & Dementia. Amsterdam:Elsevier, Vol. 7. p. S802 1 p. P4-274

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

2010

Allosteric block of KCa2 channels by apamin

Lamy, C., Goodchild, S., Weatherall, KL., Jane, DE., Liégeois, J-F., Seutin, V. & Marrion, NV., 2010, In : Journal of Biological Chemistry. 285, p. 27067 - 27077

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

A novel family of negative and positive allosteric modulators of NMDA receptors

Costa, BM., Irvine, MW., Fang, G., Eaves, RJ., Mayo-Martin, MB., Skifter, DA., Jane, DE. & Monaghan, DT., Dec 2010, In : Journal of Pharmacology and Experimental Therapeutics. 335, p. 614 - 621 7 p.

Research output: Contribution to journalArticle (Academic Journal)

59 Citations (Scopus)

Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulate neurones

Suárez, F., Zhao, Q., Monaghan, DT., Jane, DE., Jones, S. & Gibb, AJ., 2010, In : European Journal of Neuroscience. 32, p. 359 - 367

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Mapping the Ligand Binding Sites of Kainate Receptors: Molecular Determinants of Subunit-selective Binding of the Antagonist [3H]UBP310

Atlason, PT., Scholefield, CL., Eaves, RJ., Mayo-Martin, MB., Jane, DE. & Molnar, E., Dec 2010, In : Molecular Pharmacology. 78, p. 1036 - 1045 10 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization

Lennon, SM., Rivero, G., Matharu, A., Howson, PA., Jane, DE., Roberts, PJ. & Kelly, E., 2010, In : European Journal of Pharmacology. 649, p. 29 - 37 9 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Small conductance calcium-activated potassium channels: from structure to function

Weatherall, KL., Goodchild, S., Jane, DE. & Marrion, NV., Jul 2010, In : Progress in Neurobiology. 91, 10, p. 242 - 255 14 p.

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)
2009

ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function

Dargan, SL., Clarke, VRJ., Alushin, GM., Sherwood, JL., Nistico, RG., Bortolotto, ZA., Ogden, AM., Bleakman, D., Doherty, AJ., Lodge, D., Mayer, ML., Fitzjohn, SM., Jane, DE. & Collingridge, GL., Jan 2009, In : Neuropharmacology. 56, 1, p. 121 - 130 10 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Antagonism of recombinant and native GluK3-containing kainate receptors

Perrais, D., Pinheiro, PS., Jane, DE. & Mulle, C., Jan 2009, In : Neuropharmacology. 56, 1, p. 131 - 140 10 p.

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2

Sigalas, C., Mayo-Martin, MB., Jane, DE. & Sitsapesan, R., Oct 2009, In : Biophysical Journal. 97, p. 1907 - 1916 9 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Chapter 2 Gluk1 Receptor Antagonists and Hippocampal Mossy Fiber Function

Nistico, RG., Dargan, SL., Fitzjohn, SM., Lodge, D., Jane, DE., Collingridge, GL. & Bortolotto, ZA., Jul 2009, In : International Review of Neurobiology. 85, p. 13 - 27 15 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Dynamin-dependent membrane drift recruits AMPA receptors to dendritic spines

Jaskolski, F., Bayo-Martin, B., Jane, D. E. & Henley, J. M., May 2009, In : Journal of Biological Chemistry. 284, 18, p. 12491 - 12503 12 p.

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Kainate receptors: Pharmacology, function and therapeutic potential

Jane, DE., Lodge, D. & Collingridge, GL., Jan 2009, In : Neuropharmacology. 56(1), p. 90 - 113 24 p.

Research output: Contribution to journalArticle (Academic Journal)

178 Citations (Scopus)

Mechanisms of antagonism of the GluR2 AMPA receptor: Structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain

Ahmed, AH., Thompson, M., Fenwick, MK., Romero, B., Loh, AP., Jane, DE., Sondermann, H. & Oswald, RE., 2009, In : Biochemistry. 48, p. 3894 - 3903

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Neuronal calcium sensors and synaptic plasticity

Amici, M., Doherty, AJ., Jo, J., Jane, DE., Cho, K., Collingridge, GL. & Dargan, SL., Dec 2009, In : Biochemical Society Transactions. 37, p. 1359 - 1363 4 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)

NMDA receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives; preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse

Costa, BM., Feng, B., Tsintsadze, TS., Morley, RM., Irvine, MW., Tsintsadze, VP., Lozovaya, NA., Jane, DE. & Monaghan, DT., 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, p. 618 - 626

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Stereochemistry in Drug Design

Mayo-Martin, MB. & Jane, DE., 2009, A textbook of drug design and development. Krogsgaard-Larsen, P., Liljefors, T. & Madsen, U. (eds.). Harwood academic publications, p. 75 - 88 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

2008

Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs

Harney, S., Jane, DE. & Anwyl, R., 5 Nov 2008, In : Journal of Neuroscience. 28, 45, p. 11685 - 11694 10 p.

Research output: Contribution to journalArticle (Academic Journal)

78 Citations (Scopus)

Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution

Maltsev, AS., Ahmed, AH., Fenwick, MK., Jane, DE. & Oswald, RE., 2008, In : Biochemistry. 47, p. 10600 - 10610

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones

Brothwell, SLC., Barber, JL., Monaghan, DT., Jane, DE., Gibb, AJ. & Jones, S., 2008, In : Journal of Physiology. 586.3, p. 739 - 750

Research output: Contribution to journalArticle (Academic Journal)

77 Citations (Scopus)

Pharmacology of the NMDA receptor

Monaghan, DT. & Jane, DE., 2008, Biology of the NMDA receptor. VanDongen, A. (ed.). Taylor & Francis Group, p. 257 - 282 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book