Professor David E Jane

B.A.(Cantab.), Ph.D.(Salf.), M.R.S.C.

  • BS8 1TD

1993 …2020

Research output per year

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Research Output

1993

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

Bashir, ZI., Bortolotto, ZA., Davies, CH., Beretta, N., Irving, AJ., Seal, AJ., Henley, JM., Jane, DE., Watkins, JC. & Collingridge, GL., 1993, In : Nature. 363, p. 347 - 350 3 p.

Research output: Contribution to journalArticle (Academic Journal)

616 Citations (Scopus)
1994

Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord

Jane, DE., Jones, P. L., Pook, PC-K., Tse, H-W. & Watkins, JC., Jul 1994, In : British Journal of Pharmacology. 112, p. 809 - 816 7 p.

Research output: Contribution to journalArticle (Academic Journal)

188 Citations (Scopus)

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes

Hayashi, Y., Sekiyama, N., Nakanishi, S., Jane, DE., Sunter, D. C., Birse, E. F., Udvarhelyi, P. M. & Watkins, JC., May 1994, In : Journal of Neuroscience. 14, p. 3370 - 3377 7 p.

Research output: Contribution to journalArticle (Academic Journal)

321 Citations (Scopus)
1995

Kainate receptors and mossy fiber LTP

Nistico, RG., Bortolotto, ZA., More, JC-A., Jane, DE. & Collingridge, GL., 1995, In : NeuroToxicology.

Research output: Contribution to journalArticle (Academic Journal)

2005

Contribution of synaptic and intrinsic factors to the generation of a slow (<1Hz) cortical oscillation

Cunningham, MO., Pervouchine, D., Greenhill, SD., Driver, J., Racca, C., Jane, DE., Kopell, N., Jones, RSG. & Whittington, M., 2005, Soc. for Neurosci. Abstr. p. In Press

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Glutamate Receptors:Ionotropic

Monaghan, DT., More, JC-A., Feng, B. & Jane, DE., 2005, Dopamine and glutamate in psychiatric disorders. Humana Press, p. 79 - 116

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

1 Citation (Scopus)

Identification of subunit-specific and antagonist-specific amino acids in the NMDA receptor glutamate binding pocket

Kinarsky, L., Feng, B., Skifter, D., Morley, RM., Sherman, S., Jane, DE. & Monaghan, DT., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, p. 1066 - 1074

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Kainate receptors and mossy fiber LTP

Bortolotto, ZA., Nistico, RG., More, JC-A., Jane, DE. & Collingridge, GL., 2005, In : NeuroToxicology. p. 769 - 777

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists

Morley, RM., Tse, HW., Feng, B., Miller, JC., Monaghan, DT. & Jane, DE., Apr 2005, In : Journal of Medicinal Chemistry. 48 (7), p. 2627 - 2637 11 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors

Dolman, NP., Troop, HM., More, JC-A., Alt, A., Knauss, JL., Nistico, RG., Jack, S., Morley, RM., Bortolotto, ZA., Roberts, PJ., Bleakman, D., Collingridge, GL. & Jane, DE., Dec 2005, In : Journal of Medicinal Chemistry. 48 (24), p. 7867 - 7881 15 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

The effect of competitive antagonist chain-length on NMDA receptor subunit selectivity

Feng, B., Morley, RM., Jane, DE. & Monaghan, DT., 2005, In : Neuropharmacology. 48, p. 354 - 359

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)
2006

Crystallographic analysis of novel kainate receptor antagonist complexes

Mayer, M., Dolman, NP. & Jane, DE., 2006, Biophys. Soc. p. (In Press)

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Crystal structures of the kainate receptor GluR5 ligand binding core dimer complex with novel GluR5-selective antagonists

Mayer, ML., Ghosal, A., Dolman, NP. & Jane, DE., 15 Mar 2006, In : Journal of Neuroscience. 26 (11), p. 2852 - 2861 10 p.

Research output: Contribution to journalArticle (Academic Journal)

91 Citations (Scopus)

Novel potent GLUK5 selective kainate receptor antagonists

More, JC-A., Dolman, NP., Alt, A., Knauss, JL., Bleakman, D., Collingridge, GL. & Jane, DE., 2006, Br. J. Pharmacol. p. In Press

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Structure activity relationships for novel willardiine-derived GLUK5 kainate receptor antagonists

More, JC-A., Dolman, NP., Collingridge, GL. & Jane, DE., 2006, Br. J. Pharmacol. p. In Press

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists

Dolman, NP., More, JC-A., Alt, A., Knauss, JL., Troop, HM., Bleakman, D., Collingridge, GL. & Jane, DE., 20 Apr 2006, In : Journal of Medicinal Chemistry. 49 (8), p. 2579 - 2592 14 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

Structure and dunction of NMDA receptor channels

Monaghan, DT., Boyle, J., Bean, L., Gautam, V. & Jane, DE., 2006, Biological and Biophysical Aspects of Ligand-Gated Ion Channel Receptor Superfamilies. Arias, HR. (ed.). Research Signpost, p. 259 - 274 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

The different effects on recognition memory of perirhinal kainate and NMDA glutamate receptor antagonism: implications for underlying plasticity mechanisms

Barker, GRI., Warburton, EC., Koder, TJ., Dolman, NP., More, JC-A., Aggleton, JP., Bashir, ZI., Auberson, YP., Jane, DE. & Brown, MW., 29 Mar 2006, In : Journal of Neuroscience. 26 (13), p. 3561 - 3566 6 p.

Research output: Contribution to journalArticle (Academic Journal)

88 Citations (Scopus)

The glutamate story

Watkins, JC. & Jane, DE., Jan 2006, In : British Journal of Pharmacology. 147 (Suppl 1), p. S100 - S108 9 p.

Research output: Contribution to journalArticle (Academic Journal)

164 Citations (Scopus)
2007

Dynamics of the S1S2 glutamate binding domain of GluR2 measured using 19F NMR spectroscopy

Ahmed, AH., Loh, AP., Jane, DE. & Oswald, RE., 2007, In : Journal of Biological Chemistry. 282, p. 12773 - 12784 12 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Excitatory amino acids: Ionotropic glutamate receptors

Bleakman, D., Alt, AJ., Lodge, D., Monaghan, DT., Jane, DE. & Nisenbaum, ES., 2007, Handbook of Contemporary Neuropharmacology. Sibley, DR., Hanin, I., Kuhar, M. & Skolnick, P. (eds.). Wiley-Blackwell, p. 365 - 420 56 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations

Huxter, JR., Zynyuk, LE., Roloff, E., Clarke, VRJ., Dolman, NP., More, JC-A., Jane, DE., Collingridge, GL. & Muller, RL., Feb 2007, In : Journal of Neuroscience. 27 (9), p. 2212 - 2223 12 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists

Dolman, NP., More, JC-A., Alt, A., Knauss, JL., Pentikäinen, OT., Glasser, CR., Bleakman, D., Mayer, ML., Collingridge, GL. & Jane, DE., Apr 2007, In : Journal of Medicinal Chemistry. 50 (7), p. 1558 - 1570 13 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)
2008

Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs

Harney, S., Jane, DE. & Anwyl, R., 5 Nov 2008, In : Journal of Neuroscience. 28, 45, p. 11685 - 11694 10 p.

Research output: Contribution to journalArticle (Academic Journal)

78 Citations (Scopus)

Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution

Maltsev, AS., Ahmed, AH., Fenwick, MK., Jane, DE. & Oswald, RE., 2008, In : Biochemistry. 47, p. 10600 - 10610

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones

Brothwell, SLC., Barber, JL., Monaghan, DT., Jane, DE., Gibb, AJ. & Jones, S., 2008, In : Journal of Physiology. 586.3, p. 739 - 750

Research output: Contribution to journalArticle (Academic Journal)

77 Citations (Scopus)

Pharmacology of the NMDA receptor

Monaghan, DT. & Jane, DE., 2008, Biology of the NMDA receptor. VanDongen, A. (ed.). Taylor & Francis Group, p. 257 - 282 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

The role of GLUK5-containing kainate receptors in entorhinal cortex gamma frequency oscillations

Stanger, HL., Alford, R., Jane, DE. & Cunningham, MO., 2008, In : Neural Plasticity. 12 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
2009

ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function

Dargan, SL., Clarke, VRJ., Alushin, GM., Sherwood, JL., Nistico, RG., Bortolotto, ZA., Ogden, AM., Bleakman, D., Doherty, AJ., Lodge, D., Mayer, ML., Fitzjohn, SM., Jane, DE. & Collingridge, GL., Jan 2009, In : Neuropharmacology. 56, 1, p. 121 - 130 10 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Antagonism of recombinant and native GluK3-containing kainate receptors

Perrais, D., Pinheiro, PS., Jane, DE. & Mulle, C., Jan 2009, In : Neuropharmacology. 56, 1, p. 131 - 140 10 p.

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2

Sigalas, C., Mayo-Martin, MB., Jane, DE. & Sitsapesan, R., Oct 2009, In : Biophysical Journal. 97, p. 1907 - 1916 9 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Chapter 2 Gluk1 Receptor Antagonists and Hippocampal Mossy Fiber Function

Nistico, RG., Dargan, SL., Fitzjohn, SM., Lodge, D., Jane, DE., Collingridge, GL. & Bortolotto, ZA., Jul 2009, In : International Review of Neurobiology. 85, p. 13 - 27 15 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Dynamin-dependent membrane drift recruits AMPA receptors to dendritic spines

Jaskolski, F., Bayo-Martin, B., Jane, D. E. & Henley, J. M., May 2009, In : Journal of Biological Chemistry. 284, 18, p. 12491 - 12503 12 p.

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Kainate receptors: Pharmacology, function and therapeutic potential

Jane, DE., Lodge, D. & Collingridge, GL., Jan 2009, In : Neuropharmacology. 56(1), p. 90 - 113 24 p.

Research output: Contribution to journalArticle (Academic Journal)

178 Citations (Scopus)

Mechanisms of antagonism of the GluR2 AMPA receptor: Structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain

Ahmed, AH., Thompson, M., Fenwick, MK., Romero, B., Loh, AP., Jane, DE., Sondermann, H. & Oswald, RE., 2009, In : Biochemistry. 48, p. 3894 - 3903

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Neuronal calcium sensors and synaptic plasticity

Amici, M., Doherty, AJ., Jo, J., Jane, DE., Cho, K., Collingridge, GL. & Dargan, SL., Dec 2009, In : Biochemical Society Transactions. 37, p. 1359 - 1363 4 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)

NMDA receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives; preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse

Costa, BM., Feng, B., Tsintsadze, TS., Morley, RM., Irvine, MW., Tsintsadze, VP., Lozovaya, NA., Jane, DE. & Monaghan, DT., 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, p. 618 - 626

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Stereochemistry in Drug Design

Mayo-Martin, MB. & Jane, DE., 2009, A textbook of drug design and development. Krogsgaard-Larsen, P., Liljefors, T. & Madsen, U. (eds.). Harwood academic publications, p. 75 - 88 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

2010

Allosteric block of KCa2 channels by apamin

Lamy, C., Goodchild, S., Weatherall, KL., Jane, DE., Liégeois, J-F., Seutin, V. & Marrion, NV., 2010, In : Journal of Biological Chemistry. 285, p. 27067 - 27077

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

A novel family of negative and positive allosteric modulators of NMDA receptors

Costa, BM., Irvine, MW., Fang, G., Eaves, RJ., Mayo-Martin, MB., Skifter, DA., Jane, DE. & Monaghan, DT., Dec 2010, In : Journal of Pharmacology and Experimental Therapeutics. 335, p. 614 - 621 7 p.

Research output: Contribution to journalArticle (Academic Journal)

59 Citations (Scopus)

Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulate neurones

Suárez, F., Zhao, Q., Monaghan, DT., Jane, DE., Jones, S. & Gibb, AJ., 2010, In : European Journal of Neuroscience. 32, p. 359 - 367

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Mapping the Ligand Binding Sites of Kainate Receptors: Molecular Determinants of Subunit-selective Binding of the Antagonist [3H]UBP310

Atlason, PT., Scholefield, CL., Eaves, RJ., Mayo-Martin, MB., Jane, DE. & Molnar, E., Dec 2010, In : Molecular Pharmacology. 78, p. 1036 - 1045 10 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization

Lennon, SM., Rivero, G., Matharu, A., Howson, PA., Jane, DE., Roberts, PJ. & Kelly, E., 2010, In : European Journal of Pharmacology. 649, p. 29 - 37 9 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Small conductance calcium-activated potassium channels: from structure to function

Weatherall, KL., Goodchild, S., Jane, DE. & Marrion, NV., Jul 2010, In : Progress in Neurobiology. 91, 10, p. 242 - 255 14 p.

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)
2011

Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists

Alushin, GM., Jane, DE. & Mayer, ML., 2011, In : Neuropharmacology. 60, p. 126 - 134

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Julienne, A., Montagne, A., Orset, C., Lesept, F., Jane, DE., Monaghan, D. T., Maubert, E., Vivien, D. & Ali, C., Oct 2011, In : Molecular Neurodegeneration. 6, p. 68 - 68 1 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

THERAPEUTIC AGENT AND DRUG DESIGN TARGETS: BRAIN NGF RECEPTORS

Allen, S. J., Shoemark, D. K., Hemmings, J. L., Bailey, C. D., Fahey, M. S., Tyler, S. J., Williams, C., Scoltock, S. J., Watson, J. J., Willis, C. L., Crump, M. P., Sessions, R. B. & Jane, D. E., Aug 2011, In : Journal of Psychopharmacology. 25, 8, p. A11-A11 1 p.

Research output: Contribution to journalSpecial issue (Academic Journal)

Towards a model of sporadic Alzheimer’s disease: aiding design of small molecule TrkA agonists

Watson, J., Shoemark, D., Hemmings, J. L., Tyler, S., Fahey, M., Williams, C., Bailey, C., McArdle, C., Caunt, J., Jane, D., Sessions, R., Crump, M., Willis, C. & Allen-Birt, S., 1 Jul 2011, Alzheimer's & Dementia. Amsterdam:Elsevier, Vol. 7. p. S802 1 p. P4-274

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)