Professor David E Jane

B.A.(Cantab.), Ph.D.(Salf.), M.R.S.C.

  • BS8 1TD

1993 …2020

Research output per year

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Research Output

2008

The role of GLUK5-containing kainate receptors in entorhinal cortex gamma frequency oscillations

Stanger, HL., Alford, R., Jane, DE. & Cunningham, MO., 2008, In : Neural Plasticity. 12 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
2007

Dynamics of the S1S2 glutamate binding domain of GluR2 measured using 19F NMR spectroscopy

Ahmed, AH., Loh, AP., Jane, DE. & Oswald, RE., 2007, In : Journal of Biological Chemistry. 282, p. 12773 - 12784 12 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Excitatory amino acids: Ionotropic glutamate receptors

Bleakman, D., Alt, AJ., Lodge, D., Monaghan, DT., Jane, DE. & Nisenbaum, ES., 2007, Handbook of Contemporary Neuropharmacology. Sibley, DR., Hanin, I., Kuhar, M. & Skolnick, P. (eds.). Wiley-Blackwell, p. 365 - 420 56 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Inhibition of kainate receptors reduces the frequency of hippocampal theta oscillations

Huxter, JR., Zynyuk, LE., Roloff, E., Clarke, VRJ., Dolman, NP., More, JC-A., Jane, DE., Collingridge, GL. & Muller, RL., Feb 2007, In : Journal of Neuroscience. 27 (9), p. 2212 - 2223 12 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Synthesis and Pharmacological Characterization of N3-Substituted Willardiine Derivatives: Role of the Substituent at the 5-Position of the Uracil Ring in the Development of Highly Potent and Selective GLUK5 Kainate Receptor Antagonists

Dolman, NP., More, JC-A., Alt, A., Knauss, JL., Pentikäinen, OT., Glasser, CR., Bleakman, D., Mayer, ML., Collingridge, GL. & Jane, DE., Apr 2007, In : Journal of Medicinal Chemistry. 50 (7), p. 1558 - 1570 13 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)
2006

Crystallographic analysis of novel kainate receptor antagonist complexes

Mayer, M., Dolman, NP. & Jane, DE., 2006, Biophys. Soc. p. (In Press)

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Crystal structures of the kainate receptor GluR5 ligand binding core dimer complex with novel GluR5-selective antagonists

Mayer, ML., Ghosal, A., Dolman, NP. & Jane, DE., 15 Mar 2006, In : Journal of Neuroscience. 26 (11), p. 2852 - 2861 10 p.

Research output: Contribution to journalArticle (Academic Journal)

91 Citations (Scopus)

Novel potent GLUK5 selective kainate receptor antagonists

More, JC-A., Dolman, NP., Alt, A., Knauss, JL., Bleakman, D., Collingridge, GL. & Jane, DE., 2006, Br. J. Pharmacol. p. In Press

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Structure activity relationships for novel willardiine-derived GLUK5 kainate receptor antagonists

More, JC-A., Dolman, NP., Collingridge, GL. & Jane, DE., 2006, Br. J. Pharmacol. p. In Press

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists

Dolman, NP., More, JC-A., Alt, A., Knauss, JL., Troop, HM., Bleakman, D., Collingridge, GL. & Jane, DE., 20 Apr 2006, In : Journal of Medicinal Chemistry. 49 (8), p. 2579 - 2592 14 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

Structure and dunction of NMDA receptor channels

Monaghan, DT., Boyle, J., Bean, L., Gautam, V. & Jane, DE., 2006, Biological and Biophysical Aspects of Ligand-Gated Ion Channel Receptor Superfamilies. Arias, HR. (ed.). Research Signpost, p. 259 - 274 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

The different effects on recognition memory of perirhinal kainate and NMDA glutamate receptor antagonism: implications for underlying plasticity mechanisms

Barker, GRI., Warburton, EC., Koder, TJ., Dolman, NP., More, JC-A., Aggleton, JP., Bashir, ZI., Auberson, YP., Jane, DE. & Brown, MW., 29 Mar 2006, In : Journal of Neuroscience. 26 (13), p. 3561 - 3566 6 p.

Research output: Contribution to journalArticle (Academic Journal)

88 Citations (Scopus)

The glutamate story

Watkins, JC. & Jane, DE., Jan 2006, In : British Journal of Pharmacology. 147 (Suppl 1), p. S100 - S108 9 p.

Research output: Contribution to journalArticle (Academic Journal)

164 Citations (Scopus)
2005

Contribution of synaptic and intrinsic factors to the generation of a slow (<1Hz) cortical oscillation

Cunningham, MO., Pervouchine, D., Greenhill, SD., Driver, J., Racca, C., Jane, DE., Kopell, N., Jones, RSG. & Whittington, M., 2005, Soc. for Neurosci. Abstr. p. In Press

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Glutamate Receptors:Ionotropic

Monaghan, DT., More, JC-A., Feng, B. & Jane, DE., 2005, Dopamine and glutamate in psychiatric disorders. Humana Press, p. 79 - 116

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

1 Citation (Scopus)

Identification of subunit-specific and antagonist-specific amino acids in the NMDA receptor glutamate binding pocket

Kinarsky, L., Feng, B., Skifter, D., Morley, RM., Sherman, S., Jane, DE. & Monaghan, DT., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, p. 1066 - 1074

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Kainate receptors and mossy fiber LTP

Bortolotto, ZA., Nistico, RG., More, JC-A., Jane, DE. & Collingridge, GL., 2005, In : NeuroToxicology. p. 769 - 777

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists

Morley, RM., Tse, HW., Feng, B., Miller, JC., Monaghan, DT. & Jane, DE., Apr 2005, In : Journal of Medicinal Chemistry. 48 (7), p. 2627 - 2637 11 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors

Dolman, NP., Troop, HM., More, JC-A., Alt, A., Knauss, JL., Nistico, RG., Jack, S., Morley, RM., Bortolotto, ZA., Roberts, PJ., Bleakman, D., Collingridge, GL. & Jane, DE., Dec 2005, In : Journal of Medicinal Chemistry. 48 (24), p. 7867 - 7881 15 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

The effect of competitive antagonist chain-length on NMDA receptor subunit selectivity

Feng, B., Morley, RM., Jane, DE. & Monaghan, DT., 2005, In : Neuropharmacology. 48, p. 354 - 359

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)
1995

Kainate receptors and mossy fiber LTP

Nistico, RG., Bortolotto, ZA., More, JC-A., Jane, DE. & Collingridge, GL., 1995, In : NeuroToxicology.

Research output: Contribution to journalArticle (Academic Journal)

1994

Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord

Jane, DE., Jones, P. L., Pook, PC-K., Tse, H-W. & Watkins, JC., Jul 1994, In : British Journal of Pharmacology. 112, p. 809 - 816 7 p.

Research output: Contribution to journalArticle (Academic Journal)

188 Citations (Scopus)

Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes

Hayashi, Y., Sekiyama, N., Nakanishi, S., Jane, DE., Sunter, D. C., Birse, E. F., Udvarhelyi, P. M. & Watkins, JC., May 1994, In : Journal of Neuroscience. 14, p. 3370 - 3377 7 p.

Research output: Contribution to journalArticle (Academic Journal)

321 Citations (Scopus)
1993

Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors

Bashir, ZI., Bortolotto, ZA., Davies, CH., Beretta, N., Irving, AJ., Seal, AJ., Henley, JM., Jane, DE., Watkins, JC. & Collingridge, GL., 1993, In : Nature. 363, p. 347 - 350 3 p.

Research output: Contribution to journalArticle (Academic Journal)

616 Citations (Scopus)