Professor David Murphy

B.Sc.(Edin.), Ph.D.(Lond.)

Professor of Experimental Medicine, Bristol Medical School (THS)
Laboratories for Integrative Neuroscience and Endocrinology
Molecular Neuroendocrinology Research Group
Bristol Neuroscience

https://orcid.org/0000-0003-2946-0353

EmailD.Murphy@bristol.ac.uk

BS1 3NY

Research output per year

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Personal profile

Research interests

The Molecular Neueroendocrinology Research Group uses gene discovery and transfer techniques to study the neuronal regulation of the cardiovascular system in health and disease. Interests have focussed on hypothalamic neurons involved in the maintenance of plasma osmolality, and the integration of autonomic cardiovascular signalling by brainstem (nucleus of the solitary tract; NTS) neurons (in collaboration with Dr Julian Paton, Dept of Physiology, University of Bristol).

We are using microarray, differential screening and yeast two-hybrid methodologies to identify genes expressed in hypothalamic and brainstem neurons, and genes which alter their pattern of expression following physiological challenges. The hypotheses that emerge from the analysis of expression information must be tested with genetic methods involving the transfer of genes into model organisms. We have accumulated considerable experience with the generation and analysis of transgenic models; both germline systems mediated by the microinjection of fertilised one-cell eggs with cloned DNA fragments, and somatic systems mediated by the stereotaxic injection of Adenoviral gene transfer vectors into specific brain regions. Current strategies involve combining gene discovery with precise real-time physiological measurements.

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Projects

1 Active
10 Finished

The role of RNA binding protein Caprin2 in osmoregulatory dysfunction in old age.

Murphy, D.

1/09/18 → 31/08/22

Project: Research

The neurohumoral control of body fluid and cardiovascular homeostasis in males and females - vive la difference!

Murphy, D.

1/12/19 → 31/12/19

Project: Research

Environmental genomics of water conservation in a desert-adapted rodent

Murphy, D.

1/04/18 → 31/05/18

Project: Research

Research Output

140 Article (Academic Journal)
6 Chapter in a book
5 Conference Contribution (Conference Proceeding)
1 Authored book
4 More

Transcription factor Creb3l1 regulates the synthesis of prohormone convertase enzyme PC1/3 in endocrine cells

Greenwood, M., Paterson, A., Rahman, P. A., Gillard, B. T., Langley, S., Iwasaki, Y., Murphy, D. & Greenwood, M. P., 28 Apr 2020, In : Journal of Neuroendocrinology. 32, 4, 15 p., E12851.

Research output: Contribution to journal › Article (Academic Journal)

Open Access

File

25 Downloads (Pure)

Vasopressin & oxytocin in control of the cardiovascular system: An updated review

Japundžić-žigon, N., Lozić, M., Šarenac, O. & Murphy, D., 1 Jan 2020, In : Current Neuropharmacology. 18, 1, p. 14-33 20 p.

Research output: Contribution to journal › Book/Film/Article review (Academic Journal)

2 Citations (Scopus)

Vasopressin and v1br gene expression is increased in the hypothalamic pvn of borderline hypertensive rats

Savić, B., Martin, A., de Souza Mecawi, A., Bukumirić, Z., Antunes-Rodrigues, J., Murphy, D., Sarenac, O. & Japundžić–Žigon, N., 15 May 2020, In : Hypertension Research. 2020, 10 p.

Research output: Contribution to journal › Article (Academic Journal)