Research output per year
Research output per year
B.Sc.(Edin.), Ph.D.(Lond.)
BS1 3NY
The Molecular Neueroendocrinology Research Group uses gene discovery and transfer techniques to study the neuronal regulation of the cardiovascular system in health and disease. Interests have focussed on hypothalamic neurons involved in the maintenance of plasma osmolality, and the integration of autonomic cardiovascular signalling by brainstem (nucleus of the solitary tract; NTS) neurons (in collaboration with Dr Julian Paton, Dept of Physiology, University of Bristol).
We are using microarray, differential screening and yeast two-hybrid methodologies to identify genes expressed in hypothalamic and brainstem neurons, and genes which alter their pattern of expression following physiological challenges. The hypotheses that emerge from the analysis of expression information must be tested with genetic methods involving the transfer of genes into model organisms. We have accumulated considerable experience with the generation and analysis of transgenic models; both germline systems mediated by the microinjection of fertilised one-cell eggs with cloned DNA fragments, and somatic systems mediated by the stereotaxic injection of Adenoviral gene transfer vectors into specific brain regions. Current strategies involve combining gene discovery with precise real-time physiological measurements.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Murphy, D. (Principal Investigator)
1/09/22 → 31/08/25
Project: Research
Murphy, D. (Principal Investigator)
1/12/20 → 30/11/22
Project: Research
Murphy, D. (Principal Investigator)
1/12/19 → 31/12/19
Project: Research
Elbers, J. P. (Contributor), Rogers, M. F. (Contributor), Perelman, P. L. (Contributor), Proskuryakova, A. A. (Contributor), Serdyukova, N. A. (Contributor), Johnson, W. E. (Contributor), Horin, P. (Contributor), Corander, J. (Contributor), Murphy, D. (Contributor) & Burger, P. A. (Contributor), Dryad, 27 Mar 2019
DOI: 10.5061/dryad.6rp36b6, http://datadryad.org/stash/dataset/doi:10.5061/dryad.6rp36b6
Dataset
Murphy, D. (Recipient), 2004
Prize: Prizes, Medals, Awards and Grants
Murphy, D. (Recipient), 2012
Prize: Prizes, Medals, Awards and Grants
Murphy, D. (Participant)
Activity: Participating in or organising an event types › Participation in conference
Murphy, D. (Participant)
Activity: Participating in or organising an event types › Participation in conference
Murphy, D. (Member)
Activity: Membership types › Membership or peer review panel or committee