Dr Deborah K Shoemark

B.Sc., Ph.D.(Bristol)

  • BS8 1TD

20012020

Research output per year

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Research Output

2020

Expression and retention of thymidine phosphorylase in cultured reticulocytes as a novel treatment for MNGIE

Meinders, M., Shoemark, D. K., Dobbe, J. G. G., Streekstra, G. J., Frayne, J. & Toye, A. M., 12 Jun 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 822-830 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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19 Downloads (Pure)

Small-residue packing motifs modulate the structure and function of a minimal de novo membrane protein

Curnow, P., Hardy, B. J., Dufour, V., Arthur, C. J., Stenner, R., Hodgson, L. R., Verkade, P., Williams, C., Shoemark, D. K., Sessions, R. B., Crump, M. P., Jones, M. R. & Ross Anderson, J. L., 26 Jun 2020, (Accepted/In press) In : Scientific Reports.

Research output: Contribution to journalArticle (Academic Journal)

2019

Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

Smith, S. A., Sessions, R. B., Shoemark, D. K., Williams, C., Ebrahimighaei, R., McNeill, M. C., Crump, M. P., McKay, T. R., Harris, G., Newby, A. C. & Bond, M., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1291-1305 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
316 Downloads (Pure)

Emergence of a Thrombospondin Superfamily at the Origin of Metazoans

Shoemark, D., Ziegler, B., Watanabe, H., Strompen, J., Tucker, R. P., Ozbek, S. & Adams, J., 1 Jun 2019, In : Molecular Biology and Evolution. 36, 6, p. 1220-1238 19 p., msz060.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
150 Downloads (Pure)

Guiding Biomolecular Interactions in Cells Using de Novo Protein - Protein Interfaces

Smith, A., Thomas, F., Shoemark, D., Woolfson, D. & Savery, N., 21 Jun 2019, In : ACS Synthetic Biology. 8, 6, p. 1284-1293 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
22 Downloads (Pure)

Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor: Insights from Equilibrium and Nonequilibrium Simulations

Oliveira, A. S. F., Shoemark, D. K., Campello, H. R., Wonnacott, S., Gallagher, T., Sessions, R. B. & Mulholland, A. J., 2 Jul 2019, In : Structure. 27, 7, p. 1171-1183.e3 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
22 Downloads (Pure)

Modelling the early evolution of extracellular matrix from modern Ctenophores and Sponges

Draper, G. W., Shoemark, D. K. & Adams, J. C., 13 Aug 2019, In : Essays in Biochemistry. 63, 3, p. 389-405 17 p.

Research output: Contribution to journalReview article (Academic Journal)

1 Citation (Scopus)

The dynamical interplay between a megadalton peptide nanocage and solutes probed by microsecond atomistic MD; Implications for design

Shoemark, D. K., Avila Ibarra, A., Ross, J. F., Beesley, J. L., Bray, H. E. V., Mosayebi, M., Linden, N., Liverpool, T. B., McIntosh-Smith, S. N., Woolfson, D. N. & Sessions, R. B., Jan 2019, In : Physical Chemistry Chemical Physics. 21, 1, p. 137-147 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
244 Downloads (Pure)
2018

Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin

Shoemark, D., Sessions, R., Brancaccio, A. & Bigotti, M. G., Apr 2018, In : FASEB Journal. 32, 4, p. 2223-2234 12 p., fj.201701061R.

Research output: Contribution to journalArticle (Academic Journal)

File
212 Downloads (Pure)

The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity

Lalaurie, C. J., Dufour, V., Meletiou, A., Ratcliffe, S., Harland, A., Wilson, O., Vamasiri, C., Shoemark, D. K., Williams, C., Arthur, C. J., Sessions, R. B., Crump, M. P., Anderson, J. L. R. & Curnow, P., 1 Oct 2018, In : Scientific Reports. 8, 12 p., 14564.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
266 Downloads (Pure)

The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes

Wyatt, R., Brigatti, C., Liberati, D., Grace, S., Gillard, B., Long, A., Marzinotto, I., Shoemark, D., Chandler, K., Achenbach, P., Gillespie, K., Piemonti, L., Lampasona, V. & Williams, A., 1 Jul 2018, In : Diabetic Medicine. 35, 7, p. 954-963 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
201 Downloads (Pure)

Unlocking Nicotinic Selectivity via Direct C‒H Functionalization of ()-Cytisine

Rego Campello, H., Garcia Del Villar, S., Honraedt, A., Minguez Viñas, T., Oliveira, S., Ranaghan, K., Shoemark, D., Bermudez, I., Gotti, C., Sessions, R., Mulholland, A., Wonnacott, S. & Gallagher, T., 12 Jul 2018, In : Chem. 4, 7, p. 1710-1725 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
191 Downloads (Pure)
2017

16S rRNA next generation sequencing analysis shows bacteria in Alzheimer’s post-mortem brain

Emery, D., Shoemark, D., Batstone, T., Waterfall, C., Coghill, J., Cerajewska, T., Davies, M., West, N. & Allen-Birt, S., 20 Jun 2017, In : Frontiers in Aging Neuroscience. 9, 13 p., 195.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
65 Citations (Scopus)
325 Downloads (Pure)

ACTN1 variants associated with thrombocytopenia

Westbury, S. K., Shoemark, D. K. & Mumford, A. D., Sep 2017, In : Platelets. 28, 6, p. 625-627 3 p.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
File
6 Citations (Scopus)
220 Downloads (Pure)

Bacterial burden in disease, aging and Alzheimer’s disease

Shoemark, D. & Allen-Birt, S., 1 Mar 2017, Handbook of Infection and Alzheimer’s Disease. Miklossy, J. (ed.). IOS Press, p. 133-149 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
173 Downloads (Pure)

Beyond icosahedral symmetry in packings of proteins in spherical shells

Mosayebi, M., Shoemark, D. K., Fletcher, J. M., Sessions, R. B., Linden, N., Woolfson, D. N. & Liverpool, T. B., 22 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 34, p. 9014-9019 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
298 Downloads (Pure)

Decorating Self-Assembled Peptide Cages with Proteins

Ross, J. F., Bridges, A., Fletcher, J. M., Shoemark, D., Alibhai, D., Bray, H. E. V., Beesley, J. L., Dawson, W. M., Hodgson, L. R., Mantell, J., Verkade, P., Edge, C. M., Sessions, R. B., Tew, D. & Woolfson, D. N., 22 Aug 2017, In : ACS Nano. 11, 8, p. 7901-7914 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
27 Citations (Scopus)
271 Downloads (Pure)

Relación entre enfermedad periodontal y enfermedad de Alzheimer: ¿El cepillado de los dientes puede influir en la enfermedad de Alzheimer?

West, N., Shoemark, D., Davies, M. & Allen-Birt, S., 23 May 2017, In : Periodoncia Clinica. 2017, 8, p. 63-76 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
76 Downloads (Pure)
2015

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Shoemark, D. K., Williams, C., Fahey, M. S., Watson, J. J., Tyler, S. J., Scoltock, S. J., Ellis, R., Wickendon, E., Burton, A. J., Hemmings, J. L. L., Bailey, C. D., Dawbarn, D., Jane, D. E., Willis, C. L., Sessions, R. B., Allen, S. J. & Crump, M. P., 22 Jan 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 767-777 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
249 Downloads (Pure)

The Microbiome and Disease: Reviewing the Links between the Oral Microbiome, Aging, and Alzheimer's Disease

Shoemark, D. K. & Allen, S. J., 2015, In : Journal of Alzheimer's Disease. 43, 3, p. 725-38 14 p.

Research output: Contribution to journalArticle (Academic Journal)

78 Citations (Scopus)
2013

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U. & Patel, N. K., May 2013, In : Pharmacology and Therapeutics. 138, 2, p. 155 21 p., JPT-06525.

Research output: Contribution to journalArticle (Academic Journal)

376 Citations (Scopus)

Identification of novel small molecule TGF-β antagonists using structure-based drug design

Wang, H., Sessions, R. B., Prime, S. S., Shoemark, D. K., Allen-Birt, S. J., Hong, W., Narayanan, S. & Paterson, I. C., 2013, In : Journal of Computer Aided Design. 27, 0920-654X, p. 365-372 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

The Core Cysteines, (C909) of Islet Antigen-2 and (C945) of Islet Antigen-2β, Are Crucial to Autoantibody Binding in Type 1 Diabetes

Elvers, K. T., Geoghegan, I., Shoemark, D. K., Lampasona, V., Bingley, P. J. & Williams, A. J. K., Jan 2013, In : Diabetes. 62, 1, p. 214-222 8 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
2011

THERAPEUTIC AGENT AND DRUG DESIGN TARGETS: BRAIN NGF RECEPTORS

Allen, S. J., Shoemark, D. K., Hemmings, J. L., Bailey, C. D., Fahey, M. S., Tyler, S. J., Williams, C., Scoltock, S. J., Watson, J. J., Willis, C. L., Crump, M. P., Sessions, R. B. & Jane, D. E., Aug 2011, In : Journal of Psychopharmacology. 25, 8, p. A11-A11 1 p.

Research output: Contribution to journalSpecial issue (Academic Journal)

Towards a model of sporadic Alzheimer’s disease: aiding design of small molecule TrkA agonists

Watson, J., Shoemark, D., Hemmings, J. L., Tyler, S., Fahey, M., Williams, C., Bailey, C., McArdle, C., Caunt, J., Jane, D., Sessions, R., Crump, M., Willis, C. & Allen-Birt, S., 1 Jul 2011, Alzheimer's & Dementia. Amsterdam:Elsevier, Vol. 7. p. S802 1 p. P4-274

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

2009

Increasing the substrate specificity of Bacillus stearothermophillus lactate dehydrogenase by DNA shuffling

Binay, B., Shoemark, DK., Sessions, RB., Clarke, AR. & Gul-Karaguler, N., Dec 2009, In : Biochemical Engineering Journal. 48 (1), p. 118 - 123 6 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Protein 4.2 : A complex linker

Satchwell, TJ., Shoemark, DK., Sessions, RB. & Toye, AM., May 2009, In : Blood Cells, Molecules, and Diseases. 42 (3), p. 201 - 210 10 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)
2007

Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum

Shoemark, DK., Cliff, MJ., Sessions, RB. & Clarke, AR., Jun 2007, In : FEBS Journal. 274 (11), p. 2738 - 2748 11 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)
2006

NGF receptor TrkAd5: Therapeutic agent and drug design target

Dawbarn, D., Fahey, MS., Watson, JJ., Tyler, SJ., Shoemark, DK., Zhang, R., Brady, L., Willis, CL. & Allen, SJ., Aug 2006, In : Biochemical Society Transactions. 34 (4), p. 587 - 590 4 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)
2004

Cloning, sequence and expression of the lactate dehydrogenase gene from human malaria parasite, Plasmodium vivax

Turgut-Balik, D., Akbulut, E., Shoemark, DK., Celik, V., Moreton, KM., Sessions, RB., Holbrook, JJ. & Brady, RL., 2004, In : Biotechnology Letters. 26, p. 1051 - 1055 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Cloning, sequence and expression of the lactate dehydrogenase gene from the human malaria parasite, Plasmodium vivax

Turgut-Balik, D., Akbulut, E., Shoemark, D. K., Celik, V., Moreton, K. M., Sessions, R. B., Holbrook, J. J. & Brady, R. L., 1 Jul 2004, In : Biotechnology Letters. 26, 13, p. 1051-1055 5 p.

Research output: Contribution to journalArticle (Academic Journal)

2001

Mutagenic exploration of the active site of lactate dehydrogenase from Plasmodium falciparum

Turgut-Balik, D., Shoemark, D. K., Sessions, R. B., Moreton, K. M. & Holbrook, J. J., Jun 2001, In : Biotechnology Letters. 23, 11, p. 923-927 5 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Over-production of lactate dehydrogenase from Plasmodium falciparum opens a route to new antimalarials

Turgut-Balik, D., Shoemark, D. K., Moreton, K. M., Sessions, R. B. & Holbrook, J. J., Jun 2001, In : Biotechnology Letters. 23, 11, p. 917-921 5 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)