Dr Deborah K Shoemark

B.Sc., Ph.D.(Bristol)

  • BS8 1TD

20012020

Research output per year

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Research Output

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Article (Academic Journal)
2020

Expression and retention of thymidine phosphorylase in cultured reticulocytes as a novel treatment for MNGIE

Meinders, M., Shoemark, D. K., Dobbe, J. G. G., Streekstra, G. J., Frayne, J. & Toye, A. M., 12 Jun 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 822-830 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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27 Downloads (Pure)

LIR-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Jimenez Moreno, N., Stathakos, P., Anton, Z., Shoemark, D. K., Sessions, R. B., Witzgall, R., Caldwell, M. A. & Lane, J. D., 2020, (Submitted) In : The Journal of cell biology.

Research output: Contribution to journalArticle (Academic Journal)

Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors and suggest subtype specificity

Oliveira, A., Avila Ibarra, A., Casalino, L., Gaieb, Z., Shoemark, D. K., Gallagher, T., Sessions, R. B., Amaro, R. E. & Mulholland, A. J., 21 Jul 2020, (Unpublished) In : bioRxiv. 15 p.

Research output: Contribution to journalArticle (Academic Journal)

File
8 Downloads (Pure)

Small-residue packing motifs modulate the structure and function of a minimal de novo membrane protein

Curnow, P., Hardy, B. J., Dufour, V., Arthur, C. J., Stenner, R., Hodgson, L. R., Verkade, P., Williams, C., Shoemark, D. K., Sessions, R. B., Crump, M. P., Jones, M. R. & Ross Anderson, J. L., 26 Jun 2020, (Accepted/In press) In : Scientific Reports.

Research output: Contribution to journalArticle (Academic Journal)

2019

Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking

Smith, S. A., Sessions, R. B., Shoemark, D. K., Williams, C., Ebrahimighaei, R., McNeill, M. C., Crump, M. P., McKay, T. R., Harris, G., Newby, A. C. & Bond, M., 14 Feb 2019, In : Journal of Medicinal Chemistry. 62, 3, p. 1291-1305 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
329 Downloads (Pure)

Emergence of a Thrombospondin Superfamily at the Origin of Metazoans

Shoemark, D., Ziegler, B., Watanabe, H., Strompen, J., Tucker, R. P., Ozbek, S. & Adams, J., 1 Jun 2019, In : Molecular Biology and Evolution. 36, 6, p. 1220-1238 19 p., msz060.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
159 Downloads (Pure)

Guiding Biomolecular Interactions in Cells Using de Novo Protein - Protein Interfaces

Smith, A., Thomas, F., Shoemark, D., Woolfson, D. & Savery, N., 21 Jun 2019, In : ACS Synthetic Biology. 8, 6, p. 1284-1293 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
32 Downloads (Pure)

Identification of the Initial Steps in Signal Transduction in the α4β2 Nicotinic Receptor: Insights from Equilibrium and Nonequilibrium Simulations

Oliveira, A. S. F., Shoemark, D. K., Campello, H. R., Wonnacott, S., Gallagher, T., Sessions, R. B. & Mulholland, A. J., 2 Jul 2019, In : Structure. 27, 7, p. 1171-1183.e3 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
23 Downloads (Pure)

The dynamical interplay between a megadalton peptide nanocage and solutes probed by microsecond atomistic MD; Implications for design

Shoemark, D. K., Avila Ibarra, A., Ross, J. F., Beesley, J. L., Bray, H. E. V., Mosayebi, M., Linden, N., Liverpool, T. B., McIntosh-Smith, S. N., Woolfson, D. N. & Sessions, R. B., Jan 2019, In : Physical Chemistry Chemical Physics. 21, 1, p. 137-147 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
307 Downloads (Pure)
2018

Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin

Shoemark, D., Sessions, R., Brancaccio, A. & Bigotti, M. G., Apr 2018, In : FASEB Journal. 32, 4, p. 2223-2234 12 p., fj.201701061R.

Research output: Contribution to journalArticle (Academic Journal)

File
224 Downloads (Pure)

The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity

Lalaurie, C. J., Dufour, V., Meletiou, A., Ratcliffe, S., Harland, A., Wilson, O., Vamasiri, C., Shoemark, D. K., Williams, C., Arthur, C. J., Sessions, R. B., Crump, M. P., Anderson, J. L. R. & Curnow, P., 1 Oct 2018, In : Scientific Reports. 8, 12 p., 14564.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
274 Downloads (Pure)

The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes

Wyatt, R., Brigatti, C., Liberati, D., Grace, S., Gillard, B., Long, A., Marzinotto, I., Shoemark, D., Chandler, K., Achenbach, P., Gillespie, K., Piemonti, L., Lampasona, V. & Williams, A., 1 Jul 2018, In : Diabetic Medicine. 35, 7, p. 954-963 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
216 Downloads (Pure)

Unlocking Nicotinic Selectivity via Direct C‒H Functionalization of ()-Cytisine

Rego Campello, H., Garcia Del Villar, S., Honraedt, A., Minguez Viñas, T., Oliveira, S., Ranaghan, K., Shoemark, D., Bermudez, I., Gotti, C., Sessions, R., Mulholland, A., Wonnacott, S. & Gallagher, T., 12 Jul 2018, In : Chem. 4, 7, p. 1710-1725 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
204 Downloads (Pure)
2017

16S rRNA next generation sequencing analysis shows bacteria in Alzheimer’s post-mortem brain

Emery, D., Shoemark, D., Batstone, T., Waterfall, C., Coghill, J., Cerajewska, T., Davies, M., West, N. & Allen-Birt, S., 20 Jun 2017, In : Frontiers in Aging Neuroscience. 9, 13 p., 195.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
73 Citations (Scopus)
338 Downloads (Pure)

Beyond icosahedral symmetry in packings of proteins in spherical shells

Mosayebi, M., Shoemark, D. K., Fletcher, J. M., Sessions, R. B., Linden, N., Woolfson, D. N. & Liverpool, T. B., 22 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 34, p. 9014-9019 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
315 Downloads (Pure)

Decorating Self-Assembled Peptide Cages with Proteins

Ross, J. F., Bridges, A., Fletcher, J. M., Shoemark, D., Alibhai, D., Bray, H. E. V., Beesley, J. L., Dawson, W. M., Hodgson, L. R., Mantell, J., Verkade, P., Edge, C. M., Sessions, R. B., Tew, D. & Woolfson, D. N., 22 Aug 2017, In : ACS Nano. 11, 8, p. 7901-7914 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
28 Citations (Scopus)
289 Downloads (Pure)

Relación entre enfermedad periodontal y enfermedad de Alzheimer: ¿El cepillado de los dientes puede influir en la enfermedad de Alzheimer?

West, N., Shoemark, D., Davies, M. & Allen-Birt, S., 23 May 2017, In : Periodoncia Clinica. 2017, 8, p. 63-76 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
82 Downloads (Pure)
2015

Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Shoemark, D. K., Williams, C., Fahey, M. S., Watson, J. J., Tyler, S. J., Scoltock, S. J., Ellis, R., Wickendon, E., Burton, A. J., Hemmings, J. L. L., Bailey, C. D., Dawbarn, D., Jane, D. E., Willis, C. L., Sessions, R. B., Allen, S. J. & Crump, M. P., 22 Jan 2015, In : Journal of Medicinal Chemistry. 58, 2, p. 767-777 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
256 Downloads (Pure)

The Microbiome and Disease: Reviewing the Links between the Oral Microbiome, Aging, and Alzheimer's Disease

Shoemark, D. K. & Allen, S. J., 2015, In : Journal of Alzheimer's Disease. 43, 3, p. 725-38 14 p.

Research output: Contribution to journalArticle (Academic Journal)

82 Citations (Scopus)
2013

GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration

Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U. & Patel, N. K., May 2013, In : Pharmacology and Therapeutics. 138, 2, p. 155 21 p., JPT-06525.

Research output: Contribution to journalArticle (Academic Journal)

386 Citations (Scopus)

Identification of novel small molecule TGF-β antagonists using structure-based drug design

Wang, H., Sessions, R. B., Prime, S. S., Shoemark, D. K., Allen-Birt, S. J., Hong, W., Narayanan, S. & Paterson, I. C., 2013, In : Journal of Computer Aided Design. 27, 0920-654X, p. 365-372 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

The Core Cysteines, (C909) of Islet Antigen-2 and (C945) of Islet Antigen-2β, Are Crucial to Autoantibody Binding in Type 1 Diabetes

Elvers, K. T., Geoghegan, I., Shoemark, D. K., Lampasona, V., Bingley, P. J. & Williams, A. J. K., Jan 2013, In : Diabetes. 62, 1, p. 214-222 8 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
2009

Increasing the substrate specificity of Bacillus stearothermophillus lactate dehydrogenase by DNA shuffling

Binay, B., Shoemark, DK., Sessions, RB., Clarke, AR. & Gul-Karaguler, N., Dec 2009, In : Biochemical Engineering Journal. 48 (1), p. 118 - 123 6 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Protein 4.2 : A complex linker

Satchwell, TJ., Shoemark, DK., Sessions, RB. & Toye, AM., May 2009, In : Blood Cells, Molecules, and Diseases. 42 (3), p. 201 - 210 10 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)
2007

Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum

Shoemark, DK., Cliff, MJ., Sessions, RB. & Clarke, AR., Jun 2007, In : FEBS Journal. 274 (11), p. 2738 - 2748 11 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
2006

NGF receptor TrkAd5: Therapeutic agent and drug design target

Dawbarn, D., Fahey, MS., Watson, JJ., Tyler, SJ., Shoemark, DK., Zhang, R., Brady, L., Willis, CL. & Allen, SJ., Aug 2006, In : Biochemical Society Transactions. 34 (4), p. 587 - 590 4 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)
2004

Cloning, sequence and expression of the lactate dehydrogenase gene from human malaria parasite, Plasmodium vivax

Turgut-Balik, D., Akbulut, E., Shoemark, DK., Celik, V., Moreton, KM., Sessions, RB., Holbrook, JJ. & Brady, RL., 2004, In : Biotechnology Letters. 26, p. 1051 - 1055 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Cloning, sequence and expression of the lactate dehydrogenase gene from the human malaria parasite, Plasmodium vivax

Turgut-Balik, D., Akbulut, E., Shoemark, D. K., Celik, V., Moreton, K. M., Sessions, R. B., Holbrook, J. J. & Brady, R. L., 1 Jul 2004, In : Biotechnology Letters. 26, 13, p. 1051-1055 5 p.

Research output: Contribution to journalArticle (Academic Journal)

2001

Mutagenic exploration of the active site of lactate dehydrogenase from Plasmodium falciparum

Turgut-Balik, D., Shoemark, D. K., Sessions, R. B., Moreton, K. M. & Holbrook, J. J., Jun 2001, In : Biotechnology Letters. 23, 11, p. 923-927 5 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Over-production of lactate dehydrogenase from Plasmodium falciparum opens a route to new antimalarials

Turgut-Balik, D., Shoemark, D. K., Moreton, K. M., Sessions, R. B. & Holbrook, J. J., Jun 2001, In : Biotechnology Letters. 23, 11, p. 917-921 5 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)