Dheeraj Rai

2025

Immunological Drivers and Potential Novel Drug Targets for Major Psychiatric, Neurodevelopmental, and Neurodegenerative Conditions

Dardani, C., Robinson, J. W., Jones, H. J., Rai, D., Stergiakouli , E., Grove, J., Gardner, R., Havdahl, K. A., Hemani, G., Davey Smith, G., Richardson, T. G., Gaunt, T. R. & Khandaker, G., 25 Apr 2025, (E-pub ahead of print) In: Molecular Psychiatry. 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Obsessional thinking and autistic traits are each uniquely associated with greater traits of gender dysphoria in clinical and nonclinical adult samples

Mears, K., Rai, D., Shah, P. & Ashwin, C., 17 Mar 2025, In: Molecular Autism. 16, 1, 13 p., 20.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Psychotic experiences and disorders in adolescents and young adults with borderline intellectual functioning and intellectual disabilities: Evidence from a population-based birth cohort in the United Kingdom

Dardani, C., Underwood, J. F. G., Jones, H. J., Rammos, A., Sullivan, S. A., Hull, L., Khandaker, G., Zammit, S., Rai, D. & Madley-Dowd, P. C., 5 Feb 2025, In: Psychological Medicine. 55, 8 p., e23.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Downloads (Pure)

2024

Antidepressant use during pregnancy and birth outcomes: analysis of electronic health data from the UK, Norway, and Sweden

Martin, F., Ahlqvist, V., Madley-Dowd, P. C., Lundberg, M., Cohen, J. M., Furu, K., Rai, D., Forbes, H., Easey, K. E., Håberg, S. E., Sharp, G. C., Magnusson, C. & Magnus, M., 12 Dec 2024, (Submitted) In: JAMA Network Open.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Antiseizure medication use during pregnancy and children’s neurodevelopmental outcomes

Madley-Dowd, P. C., Ahlqvist, V., Forbes, H. J., Rast, J. E., Martin, F., Zhong, C. K., Barry, C.-J. S., Berglind, D., Lundberg, M., Lyall, K. K., Newschaffer, C. J., Tomson, T., Davies, N. M., Magnusson, C., Rai, D. & Lee, B. K., 15 Nov 2024, In: Nature Communications. 15, 1, 11 p., 9640.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Association between antidepressant use during pregnancy and miscarriage: a systematic review and meta-analysis

Smith, S., Martin, F., Rai, D. & Forbes, H., 25 Jan 2024, In: BMJ Open. 14, 1, 10 p., e074600.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Associations of Autistic Traits and Autism with Incontinence and Constipation in a UK Birth Cohort

Gyamenah, P., Burrows, K., Rai, D. & Joinson, C. J., 7 Dec 2024, (E-pub ahead of print) In: Journal of Autism and Developmental Disorders. 10 p., 101710.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Childhood trauma as a mediator between autistic traits and depression: Evidence from the ALSPAC birth cohort

Underwood, J. F. G., Madley-Dowd, P. C., Dardani, C., Hull, L., Kwong, A. S. F., Pearson, R. M., Hall, J. & Rai, D., 22 Apr 2024, (Submitted) In: Psychological Medicine.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Downloads (Pure)

Corrigendum: Maternal smoking during pregnancy and offspring risk of intellectual disability: a UK-based cohort study

Madley-Dowd, P., Thomas, R., Boyd, A., Zammit, S., Heron, J. & Rai, D., 20 Nov 2024, In: Frontiers in Psychiatry. 15, 2 p., 1520856.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Effectiveness and cost-effectiveness of guided self-help for depression for autistic adults: the Autism Depression Trial (ADEPT-2) - protocol for a multicentre, randomised controlled trial of a remotely delivered low-intensity intervention

Mckeon, H. E., Cotton, L., Aldridge, R., Cape, A., Clout, M., Cooper, K., Dagnan, D., Dawn, E., Frost, J., Georgakopoulou, A., Garfield, K., Horwood, J., Ingham, B., Jervis, V., Kessler, D., Langdon, P., Metcalfe, C., Rai, D., Realpe, A. & Russell, C. & 6 others, Sheridan, H., Slowinska, K., Thorn, J., Wen, L., Wiles, N. & Russell, A., 19 Nov 2024, In: BMJ Open. 14, 11, p. e084729 10 p., e084729.

Research output: Contribution to journal › Protocol

Open Access

File

1 Citation (Scopus)

13 Downloads (Pure)

Environmental and genetic predictors of whole blood mercury and selenium concentrations in pregnant women in a UK birth cohort

Dack, K., Huang, P., Taylor, C. M., Rai, D. & Lewis, S. J., 1 Apr 2024, In: Environmental Advances. 15, 100469.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

First trimester antidepressant use and miscarriage: a comprehensive analysis in the UK Clinical Practice Research Datalink

Martin, F., Madley-Dowd, P. C., Ahlqvist, V., Sharp, G. C., Easey, K. E., Lee, B. K., Merriel, A., Rai, D. & Forbes, H., 12 Dec 2024, (Submitted) In: JAMA Network Open.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

First-trimester use of antiseizure medications and the risk of miscarriage: a population-based cohort study

Forbes, H. J., Madley-Dowd, P. C., Ahlqvist, V., Campbell, J., Davies, N. M., Liebling, R. E., Lyall, K. K., Newschaffer, C. J., Rast, J. E., Tomson, T., Zhong, C. K., Magnusson, C., Rai, D. & Lee, B. K., 1 Aug 2024, In: Journal of Neurology, Neurosurgery, and Psychiatry. 95, 8, p. 693-703 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Health Economics Analysis Plan (HEAP) for STRATA

Cochrane, M., Thorn, J. C. & Rai, D., 13 Nov 2024, 15 p.

Research output: Other contribution

Open Access

File

34 Downloads (Pure)

Making decisions about antidepressant use during pregnancy: A qualitative interview study of a sample of women in the United Kingdom

James, H., Smith, S., Rai, D., Culpin, I. & Turner, K. M., 7 Oct 2024, (E-pub ahead of print) In: British Journal of General Practice.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Mapping associations of polygenic scores with autistic and ADHD traits in a single city region

Reed, Z. E., Thomas, R. G., Boyd, A. W., Griffith, G. J., Morris, T., Rai, D., Manley, D. J., Davey Smith, G. & Davis, O. S. P., 14 Aug 2024, (E-pub ahead of print) In: Journal of Child Psychology and Psychiatry. 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Maternal smoking during pregnancy and offspring risk of intellectual disability: a UK based cohort study

Madley-Dowd, P. C., Thomas, R. G., Boyd, A. W., Zammit, S., Heron, J. E. & Rai, D., 25 Jun 2024, (E-pub ahead of print) In: Frontiers in Psychiatry. 15, 10 p., 1352077.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Patterns of antidepressant prescribing in and around pregnancy: a descriptive analysis in the UK Clinical Practice Research Datalink

Martin, F., Sharp, G. C., Easey, K. E., Madley-Dowd, P. C., Bowen, L., Nimmo-Smith, V., Sadik, A. A. S., Richardson, J. L., Rai, D. & Forbes, H., 8 Aug 2024, medRxiv.

Research output: Working paper › Preprint

Psychiatric comorbidities in epilepsy: Population co-occurrence, genetic correlations and causal effects

Ahlqvist, V., Dardani, C., Madley-Dowd, P. C., Forbes, H. J., Rast, J. E., Zhong, C. K., Gardner, R., Dalman, C., Lyall, K. K., Newschaffer, C. J., Tomson, T., Lundberg, M., Berglind, D., Davies, N. M., Lee, B. K., Magnusson, C. & Rai, D., 30 Jan 2024, In: General Psychiatry. 37, 1, p. 1-9 9 p., e101201.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Sertraline for anxiety in adults with a diagnosis of autism (STRATA): study protocol for a pragmatic, multicentre, double-blind, placebo-controlled randomised controlled trial

Rai, D., Webb, D., Lewis, A., Cotton, L., Norris, J. E., Alexander, R., Baldwin, D. S., Brugha, T., Cochrane, M., Del Piccolo, M. C., Glasson, E. J., Hatch, K. K., Kessler, D., Langdon, P. E., Leonard, H., MacNeill, S. J., Mills, N., Morales, M. V., Morgan, Z. & Mukherjee, R. & 9 others, Realpe, A. X., Russell, A., Starkstein, S., Taylor, J., Turner, N., Thorn, J., Welch, J., STRATA autistic advisory group & Wiles, N., 11 Jan 2024, In: Trials. 25, 20 p., 37.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Sex differences in self-harm and suicide in young autistic adults

Hull, L., Stark, I., Lundberg, M., Ahlqvist, V., Nordström, S. I., Ohlis, A., Hadlaczky, G., Rai, D. & Magnusson, C., 19 Jul 2024, (E-pub ahead of print) In: Acta Psychiatrica Scandinavica. 150, 4, p. 223-233 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

STRATA: A multicentre double-blind placebo-controlled randomised trial of SerTRaline for AnxieTy in adults with a diagnosis of Autism (STRATA): Statistical Analysis Plan

MacNeill, S. J., Vazquez Morales, M. & Rai, D., 13 Nov 2024, 43 p.

Research output: Other contribution

Open Access

File

30 Downloads (Pure)

Structural models of genome-wide covariance identify multiple common dimensions in autism

de Hoyos, L., Barendse, M. T., Schlag, F., van Donkelaar, M. M. J., Verhoef, E., Shapland, C. Y., Klassmann, A., Buitelaar, J., Verhulst, B., Fisher, S. E., Rai, D. & St Pourcain, B., 27 Feb 2024, In: Nature Communications. 15, 1770.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

2023

Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children

Heuvelman, H., Davies, N. M., Ben-Shlomo, Y., Emond, A., Evans, J., Gunnell, D., Liebling, R., Morris, R., Payne, R., Storey, C., Viner, M. & Rai, D., 24 Oct 2023, In: Health Technology Assessment. 27, 15, p. 1-83 83 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Antidepressant use during pregnancy and risk of stillbirth: a systematic review and meta-analysis

Martin, F., Smith, S., Rai, D. & Forbes, H., 17 May 2023, In: Reproductive, Female and Child Health. p. 1-11 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Antidepressant use during trimester one and pregnancy loss: A causal analysis in the UK CPRD

Martin, F., Madley-Dowd, P. C., Ahlqvist, V., Sharp, G. C., Easey, K. E., Rai, D. & Forbes, H., 12 Oct 2023, p. 525-526.

Research output: Contribution to conference › Conference Abstract › peer-review

1 Citation (Scopus)

Antidepressant use during trimester one and pregnancy loss: a longitudinal study using the Clinical Practice Research Datalink

Martin, F., Madley-Dowd, P. C., Sharp, G. C., Easey, K. E., Rai, D. & Forbes, H., 17 May 2023, (Accepted/In press) p. 47. 1 p.

Research output: Contribution to conference › Conference Abstract › peer-review

Associations between autistic traits and early ear and upper respiratory signs: a prospective observational study of the Avon Longitudinal Study of Parents and Children (ALSPAC) geographically defined childhood population

Hall, A. J., Maw, R., Iles-Caven , Y. L., Gregory, S., Rai, D. & Golding, J., 24 Apr 2023, In: BMJ Open. 13, 3, 9 p., e067682.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Autistic adults’ views on the design and processes within randomised controlled trials: The APRiCoT study

Beasant, L., Realpe, A., Douglas, S., Kenny, L., Rai, D. & Mills, N. J., 26 Oct 2023, In: Autism.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

3 Citations (Scopus)

Bias amplification of unobserved confounding in pharmacoepidemiological studies using indication-based sampling

Ahlqvist, V., Madley-Dowd, P. C., Ly, A., Rast, J. E., Lundberg, M., Jónsson-Bachmann, E., Berglind, D., Rai, D., Magnusson, C. & Lee, B. K., 15 Mar 2023, (E-pub ahead of print) In: Pharmacoepidemiology and Drug Safety. 32, 8, p. 886-897 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Intellectual disability in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC)

Madley-Dowd, P. C., Thomas, R. G., Boyd, A. W., Zammit, S., Heron, J. E. & Rai, D., 11 Jan 2023, In: Wellcome Open Research. 7, 172.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

4 Citations (Scopus)

130 Downloads (Pure)

Lockdown Experiences and Views on Future Research Participation of Autistic Adults in the UK During the First 6 Months of the COVID-19 Pandemic

Realpe, A. X., Mills, N., Beasant, L., Douglas, S., Kenny, L. & Rai, D., 30 Aug 2023, In: Autism in Adulthood. 5, 3, p. 301-310 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

6 Citations (Scopus)

48 Downloads (Pure)

Patterns of antidepressant prescribing during pregnancy between 1996 and 2018 using the Clinical Practice Research Datalink

Martin, F., Madley-Dowd, P. C., Sharp, G. C., Easey, K. E., Rai, D. & Forbes, H., 24 Aug 2023, p. A73. 1 p.

Research output: Contribution to conference › Conference Abstract › peer-review

Open Access

Patterns of antidepressant prescribing during pregnancy between 1996 And 2018 using the Clinical Practice Research Datalink

Martin, F., Madley-Dowd, P. C., Sharp, G. C., Easey, K. E., Rai, D. & Forbes, H., 17 Aug 2023, p. 541.

Research output: Contribution to conference › Conference Abstract › peer-review

Trends and patterns of antiseizure medication prescribing during pregnancy between 1995 and 2018 in the United Kingdom: a cohort study

Madley-Dowd, P. C., Rast, J. E., Ahlqvist, V. H., Zhong, C. K., Martin, F., Davies, N. M., Lyall, K. K., Newschaffer, C. J., Tomson, T., Magnusson, C., Rai, D., Lee, B. & Forbes, H. J., 20 Jun 2023, (E-pub ahead of print) In: BJOG: An International Journal of Obstetrics and Gynaecology. 131, 1, p. 15-25 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

10 Citations (Scopus)

2022

Autism, autistic traits and multiple risk behaviours in adolescence: a longitudinal birth cohort study

Ly, A., Heron, J. E., Rai, D. & Wright, C. L., 28 Apr 2022, (E-pub ahead of print) In: Psychological Medicine. 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

2 Citations (Scopus)

119 Downloads (Pure)

Autism and self-harm: A population-based and discordant sibling study of young individuals

Stark, I., Rai, D., Lundberg, M., Culpin, I., Nordström, S. I., Ohlis, A. & Magnusson, C., 17 Oct 2022, In: Acta Psychiatrica Scandinavica. 146, 5, p. 468-477 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

10 Citations (Scopus)

147 Downloads (Pure)

Benefits and harms of interventions to improve anxiety, depression, and other mental health outcomes for autistic people: A systematic review and network meta-analysis of randomised controlled trials

Linden, A., Best, L., Elise, F., Davidson, I., Hearst, C., Rai, D., Smith, E. & Gurusamy, K., 11 Aug 2022, In: Autism. 27, 1, p. 7-30 24 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

42 Citations (Scopus)

266 Downloads (Pure)

Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort

Dardani, C., Schalbroeck, R., Madley-Dowd, P. C., Jones, H. J., Strelchuk, D., Hammerton, G. L., Croft, J., Sullivan, S. A., Zammit, S., Selten, J.-P. & Rai, D., 26 Nov 2022, In: Schizophrenia Bulletin. 11 p., sbac167.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

3 Citations (Scopus)

197 Downloads (Pure)

Father absence and trajectories of offspring mental health across adolescence and young adulthood: Findings from a UK-birth cohort

Culpin, I., Heuvelman, H. P., Rai, D., Pearson, R. M., Joinson, C. J., Heron, J. E., Evans, J. & Kwong, A. S. F., 1 Oct 2022, In: Journal of Affective Disorders. 314, p. 150-159 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

12 Citations (Scopus)

163 Downloads (Pure)

Gendered play behaviours in autistic and non-autistic children: a population-based cohort study

Hull, L., Heuvelman, H., Golding, J., Mandy, W. & Rai, D., 20 Dec 2022, (E-pub ahead of print) In: Autism. p. 1-12

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

5 Citations (Scopus)

145 Downloads (Pure)

Genetic liability to rheumatoid arthritis on autism and autistic traits: polygenic risk score and mendelian randomization analyses

Ly, A., Leppert, B., Rai, D., Jones, H. J., Dardani, C. & Stergiakouli , E., 12 Jan 2022, In: Translational Psychiatry. 12, 1, 6 p., 18.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

3 Citations (Scopus)

131 Downloads (Pure)

Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study

Madley-Dowd, P. C., Dardani, C., Wootton, R. E., Dack, K. A. W., Palmer, T. M., Thurston, R., Havdahl, K. A., Golding, J., Lawlor, D. A. & Rai, D., 12 Nov 2022, In: Molecular Autism. 13, 1, 14 p., 44.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

7 Citations (Scopus)

55 Downloads (Pure)

Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Caramaschi, D., Neumann, A., Cardenas, A., Tindula, G., Alemany, S., Zillich, L., Pesce, G., Lahti, J. M. T., Havdahl, A., Mulder, R., Felix, J. F., Tiemeier, H., Sirignano, L., Frank, J., Witt, S. H., Rietschel, M., Deuschle, M., Huen, K., Eskenazi, B. & Send, T. S. & 20 others, Ferrer, M., Gilles, M., de Agostini, M., Baïz, N., Rifas-Shiman, S. L., Kvist, T., Czamara, D., Tuominen, S. T., Relton, C. L., Rai, D., London, S. J., Räikkönen, K., Holland, N., Annesi-Maesano, I., Streit, F., Hivert, M.-F., Oken, E., Sunyer, J., Cecil, C. A. M. & Sharp, G., 1 Apr 2022, In: Molecular Psychiatry. 27, 4, p. 2126–2135 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

15 Citations (Scopus)

66 Downloads (Pure)

Neurological and psychiatric disorders among autistic adults: a population healthcare record study

Underwood, J. F. G., DelPozo-Banos, M., Frizzati, A., Rai, D., John, A. & Hall, J., 3 Oct 2022, (E-pub ahead of print) In: Psychological Medicine. 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

13 Citations (Scopus)

45 Downloads (Pure)

Parental inflammatory bowel disease and autism in children: Triangulating the evidence using four complementary study designs

Sadik, A. A. S., Dardani, C., Pagoni, P., Havdahl, K. A., Stergiakouli , E., Grove, J., Khandaker, G. M., Sullivan, S. A., Zammit, S., Jones, H. J., Davey Smith, G., Dalman, C., Karlsson, H., Gardner, R. M. & Rai, D., 2 Jun 2022, (E-pub ahead of print) In: Nature Medicine. 28, 7, p. 1406-1411 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

35 Citations (Scopus)

132 Downloads (Pure)

2021

Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy

Verhoef, E., Grove, J., Shapland, C. Y., Demontis, D., Burgess, S., Rai, D., Børglum, A. D. & St Pourcain, M. U. B., 11 Nov 2021, In: Nature Communications. 12, 1, 6534.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

7 Citations (Scopus)

76 Downloads (Pure)

Is genetic liability to ADHD and ASD causally linked to educational attainment?

Dardani, C., Riglin, L., Leppert, B., Sanderson, E. C. M., Rai, D., Howe, L. D., Davey Smith, G., Tilling, K. M., Thapar, A., Davies, N. M., Anderson, E. L. & Stergiakouli , E., 1 Dec 2021, In: International Journal of Epidemiology. 50, 6, p. 2011-2023

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

26 Citations (Scopus)

92 Downloads (Pure)

Lockdown experiences and views on future research participation of autistic adults in the UK during the first six months of the COVID-19 pandemic

Realpe, A. X., Mills, N., Beasant, L., Douglas, S., Kenny, L. & Rai, D., 26 Oct 2021

Research output: Other contribution

Mapping the genetic and environmental aetiology of autistic traits in Sweden and the United Kingdom

Reed, Z. E., Larsson, H., Haworth , C. M. A., Rai, D., Lundström, S., Ronald, A., Reichenberg, A., Lichtenstein, P. & Davis, O. S. P., 13 Oct 2021, (E-pub ahead of print) In: Journal of Child Psychology and Psychiatry Advances.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

2 Citations (Scopus)

135 Downloads (Pure)

Professor Dheeraj Rai

Research output

Search results