Projects per year
I am a Senior Research Fellow at the Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, UK. I currently hold a post-doctoral fellowship from the MRC, which aims to improve causal inference in the life course aetiology of dementia and cognitive decline. My research focuses on applying causal inference methods such as Mendelian Randomization and offspring instrumental variable analyses to identify novel causal risk factors for dementia and cognitive decline. I also have an interest developing methods to address selection bias in Mendelian randomization studies. In addition to my fellowship, I am co-applicant on a grant from an Alzheimer’s Research charity (BRACE), which uses genetic data to identify early-life determinants and causal environmental risk factors for Alzheimer’s disease.
I completed my PhD in Epidemiology in 2014 at the University of Bristol, on the prevlence and determinants of non-alcoholic fatty liver disease in children and adolescents. My postdoctoral positions include analysis of the Active for Life Year 5 Trial (a cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet) and examining effects of childhood trauma on later-life cardiovascular and ageing outcomes. My undergraduate degree was in Human Biology (graduated 2010, 1st Class Honours, Loughborough University).
- Modelling longitudinal data (using mixed models and joint models to account for informative loss-to-follow-up) to obtain trajectories of exposures and outcomes across the life course
- Systematic reviews and meta-analyses
- Analysis of Randomised Controlled Trials
- Analysis of clustered data
- Exploratory and confirmatory factor analyses
- Mendelian randomisation (univariable and multivariable)
- Polygenic risk score analysis
- Offspring instrumental variable analysis
I am co-director of the Mendelian Randomization & Causal Inference short courses in the Bristol Medical School. I have also taught (or currently teach) on Introduction to Statistics, Systematic Reviews and Meta-analyses, Advanced Epidemiology, Analysis of Repeated Measures, and Introduction to Statistical Methods in Life Course Epidemiology. I am a tutor for the Evidence Based Medicine program delivered to first year MBChB students, and also teach 'Analysis of Clustered Data' on the Epidemiology MSc.
PhD - Prevalence and determinants of non-alcoholic fatty liver disease in children and adolescents, Bristol Medical School (PHS)
1 Oct 2010 → 30 Nov 2014
Award Date: 30 Nov 2014
BSc Human Biology (1st Class Honours), Loughborough University
1 Sept 2007 → 30 Jun 2010
Award Date: 30 Jun 2010
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1/08/22 → 31/07/26
1/11/20 → 30/11/22
1/06/17 → 31/01/22
Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization studySmith, M. L., Bull, C. J., Holmes, M. V., Davey Smith, G., Sanderson, E. C. M., Anderson, E. L. & Bell, J. A., 1 Apr 2023, In: EBioMedicine. 90, p. 1-13 104503.
Research output: Contribution to journal › Article (Academic Journal)Open Access2 Downloads (Pure)
Associations between Adverse Childhood Experiences and the novel inflammatory marker glycoprotein acetyls in two generations of the Avon Longitudinal Study of Parents and Children birth cohortCrick, D. C. P., Halligan, S. L., Howe, L. D., Lacey, R., Khandaker, G., Burgner, D., Herbert, A., Suderman, M. J., Anderson, E. L. & Fraser, A., Feb 2022, In: Brain, Behavior, and Immunity. 100, p. 112-120 9 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile3 Citations (Scopus)80 Downloads (Pure)
Causal effects of circulating cytokine concentrations on risk of Alzheimer's disease and cognitive functionPagoni, P., Korologou-Linden, R. S., Howe, L. D., Davey Smith, G., Ben-Shlomo, Y., Stergiakouli, E. & Anderson, E. L., 14 May 2022, (E-pub ahead of print) In: Brain, Behavior, and Immunity. 104, p. 54-64 11 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile9 Citations (Scopus)53 Downloads (Pure)