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Research interests
The work of my research is to understand the catalytic activity and biological function in heme containing enzymes. Heme is the prosthetic group found in a number of biologically important proteins (from haemoglobin to catalases) which have a diverse range of biological functions including electron transfer, transportation of gases and chemical catalysis. Our work is focused in three main areas: peroxidases, dioxygenases and the role of heme in the cell. We use kinetic and spectroscopic methods to understand the mechanism and function of heme enzymes, and we collaborate with structural biologists (Prof Peter Moody, University of Leicester) to provide a structural framework for our experiments.
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Research output
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Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase
Basran, J., Booth, E. S., Campbell, L. P., Thackray, S. J., Jesani, M. H., Clayden, J. P., Moody, P. C. E., Mowat, C. G., Raven, E. & Kwon, H., 1 Dec 2021, In: Journal of Inorganic Biochemistry. 225, 6 p., 111604.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Understanding the Logistics for the Distribution of Heme in Cells
Gallio, A. E., Fung, S. S. P., Cammack-Najera, A., Hudson, A. J. & Raven, E., 25 Oct 2021, In: Journal of the American Chemical Society. 1, 10, 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile15 Downloads (Pure) -
Unravelling the mechanisms controlling heme supply and demand
Leung, G. C-H., Fung, S. S-P., Gallio, A. E., Blore, R., Alibhai, D., Raven, E. L. & Hudson, A. J., 1 Jun 2021, In: Proceedings of the National Academy of Sciences. 118, 22, 9 p., e2104008118.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile4 Citations (Scopus)26 Downloads (Pure)
Activities
- 1 Visiting an external academic institution
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Japan Synchrotron Radiation Research Institute
Emma Raven (Visiting researcher)
5 Jun 2019Activity: Visiting an external institution types › Visiting an external academic institution