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Personal profile

Research interests

My main area of interest is to further understand the pathophysiology of neuropathic pain by studying the roles of factors that are differentially regulated in the dorsal root ganglion (DRG) following peripheral nerve damage. After injury to peripheral nerves there are changes in the expression of many factors - both in sensory neurons and non-neuronal cells (e.g. satellite glia and macrophages), that may contribute to the adaptive or maladaptive responses of the peripheral nervous sytem to injury, by modulating neuronal survival, regeneration and pain. I am particularly interested in the roles of chemokines, specifically CX3CL1, and the neuropeptide galanin.

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Research Output

  • 27 Article (Academic Journal)
  • 2 Conference Contribution (Conference Proceeding)
  • 1 Chapter in a book

Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain

Holmes, F. E., Kerr, N. C. H., Vanderplank, P. A., McArdle, C. & Wynick, D., 1 Jan 2017, In : Molecular and Cellular Neuroscience. 78, p. 35-40 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 8 Citations (Scopus)
    313 Downloads (Pure)

    Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor

    Gresle, M. M., Butzkueven, H., Perreau, V. M., Jonas, A., Xiao, J., Thiem, S., Holmes, F. E., Doherty, W., Soo, P-Y., Binder, M. D., Akkermann, R., Jokubaitis, V. G., Cate, H. S., Marriott, M. P., Gundlach, A. L., Wynick, D. & Kilpatrick, T. J., Jun 2015, In : Glia. 63, 6, p. 1005-1020 16 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 7 Citations (Scopus)
    300 Downloads (Pure)

    Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

    Lang, R., Gundlach, A. L., Holmes, F. E., Hobson, S., Wynick, D., Hökfelt, T. & Kofler, B., Jan 2015, In : Pharmacological Reviews. 67, 1, p. 118-175 58 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 149 Citations (Scopus)
    421 Downloads (Pure)