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Personal profile

Research interests

I am interested in ultradian rhythm of glucocorticoid secretion and the mechanisms underlying dynamic synthesis of glucocorticoid in the adrenal gland. I use a wide range of molecular and cell-signalling techniques to elucidate the dynamic of intra-adrenal processes involved in steroids synthesis and how these dynamics become disrupted in disease such as inflammation and critical illness. I collaborate with mathematicians to develop mathematical models of the intra-adrenal regulatory network using biological data obtained in our studies.

I have recently joined the University of Exeter EPSRC Centre for Predictive Modelling in Healthcaret o work on a 6-months Seed-Corn project entitled

Contribution of GABAergic signalling in the daily electrical excitability of suprachiasmatic nuclei circadian clock neurons 

funded by the Wellcome Trust and by a Practical Skills Developement grant form the Society for Endocrinology https://www.endocrinology.org/

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Research Output

  • 24 Article (Academic Journal)
  • 7 Review article (Academic Journal)
  • 1 Chapter in a book

Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH

Smith, L. I. F., Victoria Huang, Mark Olah, Loc Trinh, Ying Liu, Hazell, G., Conway-Campbell, B., Zhao, Z., Antoine Martinez, Anne-Marie Lefrancois-Martinez, Lightman, S., Spiga, F. & Greti Aguilera, 1 Jan 2020, In : Molecular and Cellular Endocrinology. 499, 11 p., 110612.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
  • 108 Downloads (Pure)
    Open Access
  • 1 Citation (Scopus)
    22 Downloads (Pure)

    Dynamics of ACTH-Mediated Regulation of Gene Transcription in ATC1 and ATC7 Adrenal Zona Fasciculata Cell Lines

    Hazell, G., Horn, G., Lightman, S. L. & Spiga, F., 15 Feb 2019, In : Endocrinology. 160, 3, p. 587-604 18 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 3 Citations (Scopus)
    185 Downloads (Pure)

    Supervised Work

    Characterisation of the stress response to heart surgery in children

    Author: Fudulu, D., 23 Jan 2020

    Supervisor: Angelini, G. (Supervisor), Lightman, S. (Supervisor), Gibbison, B. (Supervisor) & Spiga, F. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)