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Research Output

  • 24 Article (Academic Journal)
  • 7 Review article (Academic Journal)
  • 1 Chapter in a book
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Article (Academic Journal)
2020

Involvement of CREB-regulated transcription coactivators (CRTC) in transcriptional activation of steroidogenic acute regulatory protein (Star) by ACTH

Smith, L. I. F., Victoria Huang, Mark Olah, Loc Trinh, Ying Liu, Hazell, G., Conway-Campbell, B., Zhao, Z., Antoine Martinez, Anne-Marie Lefrancois-Martinez, Lightman, S., Spiga, F. & Greti Aguilera, 1 Jan 2020, In : Molecular and Cellular Endocrinology. 499, 11 p., 110612.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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117 Downloads (Pure)
Open Access
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2 Citations (Scopus)
33 Downloads (Pure)
2019

Dynamics of ACTH-Mediated Regulation of Gene Transcription in ATC1 and ATC7 Adrenal Zona Fasciculata Cell Lines

Hazell, G., Horn, G., Lightman, S. L. & Spiga, F., 15 Feb 2019, In : Endocrinology. 160, 3, p. 587-604 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
194 Downloads (Pure)
2017

Dynamic responses of the adrenal steroidogenic regulatory network

Spiga, F., Zavala, E., Walker, J., Zhao, Z., Terry, J. & Lightman, S., 1 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 31, p. E6466-E6474 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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21 Citations (Scopus)
218 Downloads (Pure)
2016

The role of hippocampal NMDA receptors in long-term emotional responses following muscarinic receptor activation

Hoeller, A. A., Costa, A. P. R., Bicca, M. A., Matheus, F. C., Lach, G., Spiga, F., Lightman, S. L., Walz, R., Collingridge, G. L., Bortolotto, Z. A. & De Lima, T. C. M., 21 Jan 2016, In : PLoS ONE. 11, 1, 18 p., e0147293.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
241 Downloads (Pure)
2015

Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery

Gibbison, B., Spiga, F., Walker, J. J., Russell, G. M., Zhao, Z., Stevenson, K., Henley, DE., Angelini, G. D. & Lightman, S. L., Apr 2015, In : Critical Care Medicine. 43, 4, p. 791-800 10 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Rapid intra-adrenal feedback regulation of glucorticoid synthesis

Walker, J., Spiga, F., Gupta, R., Zhao, Z., Lightman, S. & Terry, J., 6 Jan 2015, In : Journal of the Royal Society Interface. 12, 102, p. 20140875 1 p.

Research output: Contribution to journalArticle (Academic Journal)

2014

Hippocampus remodeling by chronic stress accompanied by GR, proteasome and caspase-3 overexpression

Orlovsky, M. A., Dosenko, V. E., Spiga, F., Skibo, G. G. & Lightman, S. L., 17 Dec 2014, In : Brain Research. 1593, p. 83-94 12 p.

Research output: Contribution to journalArticle (Academic Journal)

2013

Constant light disrupts the circadian rhythm of steroidogenic proteins in the rat adrenal gland

Park, S. Y., Walker, J. J., Johnson, N. W., Zhao, Z., Lightman, S. L. & Spiga, F., 22 May 2013, In : Molecular and Cellular Endocrinology. 371, 1-2, p. 114-123 10 p.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)
2012

The origin of glucocorticoid hormone oscillations

Walker, J. J., Spiga, F., Waite, E., Zhao, Z., Kershaw, Y., Terry, J. R. & Lightman, S. L., 2012, In : PLoS Biology. 10, 6, e1001341.

Research output: Contribution to journalArticle (Academic Journal)

101 Citations (Scopus)
2011

ACTH-Dependent Ultradian Rhythm of Corticosterone Secretion

Spiga, F., Waite, EJ., Liu, Y., Kershaw, YM., Aguilera, G. & Lightman, SL., Apr 2011, In : Endocrinology. 152(4), p. 1448 - 1457

Research output: Contribution to journalArticle (Academic Journal)

69 Citations (Scopus)

Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding

Spiga, F., Knight, DM., Droste, S-K., Conway-Campbell, BL., Kershaw, YM., MacSweeney, CP., Thomson, FJ., Craighead, M., Peeters, BW. & Lightman, SL., Feb 2011, In : Journal of Psychopharmacology. 25(2), p. 211 - 221

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)
2010

Recovery from disrupted ultradian glucocorticoid rhythmicity reveals a dissociation between hormonal and behavioural stress responsiveness

Sarabdjitsingh, RA., Spiga, F., Oitzl, MS., Kershaw, YM., Meijer, OC., Lightman, SL. & de Kloet, ER., Aug 2010, In : Journal of Neuroendocrinology. 22(8), p. 862 - 871 10 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)
2009

A glucocorticoid sensitive biphasic rhythm of testosterone secretion

Waite, EJ., Kershaw, YM., Spiga, F. & Lightman, SL., Sep 2009, In : Journal of Neuroendocrinology. 21, p. 737 - 741

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Blockade of the V(1b) receptor reduces ACTH, but not corticosterone secretion induced by stress without affecting basal hypothalamic-pituitary-adrenal axis activity

Spiga, F., Harrison, L., Wood, SA., Knight, DM., MacSweeney, CP., Thomson, FJ., Craighead, M. & Lightman, SL., Mar 2009, In : Journal of Endocrinology. 200(3), p. 273 - 283

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
17 Citations (Scopus)

Effect of vasopressin 1b receptor blockade on the hypothalamic-pituitary-adrenal response of chronically stressed rats to a heterotypic stressor

Spiga, F., Harrison, L., MacSweeney, CP., Thomson, FJ., Craighead, M. & Lightman, SL., Mar 2009, In : Journal of Endocrinology. 200(3), p. 285 - 291 7 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)
2007

Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleus

Bouwknecht, JA., Spiga, F., Staub, D., Hale, MW., Shekhar, A. & Lowry, CA., Apr 2007, In : Brain Research Bulletin. 72, p. 32 - 43 12 p.

Research output: Contribution to journalArticle (Academic Journal)

115 Citations (Scopus)

Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretion

Spiga, F., Harrison, L., Wood, SA., Atkinson, HC., MacSweeney, CP., Thomson, FJ., Craighead, M., Grassie, M. & Lightman, SL., 2007, In : Journal of Neuroendocrinology.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release

Spiga, F., Harrison, L., Wood, SA., MacSweeney, CP., Thomson, FJ., Craighead, M., Grassie, M. & Lightman, SL., Feb 2007, In : Journal of Endocrinology. 196 (2), p. 323 - 330 8 p.

Research output: Contribution to journalArticle (Academic Journal)

2006

Exposure to high- and low-light conditions in an open-field test of anxiety increases c-Fos expression in specific subdivisions of the rat basolateral amygdaloid complex

Hale, MW., Bouwknecht, JA., Spiga, F., Shekhar, A. & Lowry, CA., Dec 2006, In : Brain Research Bulletin. 71 (1-3), p. 174 - 182 10 p.

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)

Injections of urocortin 1 into the basolateral amygdala induce anxiety-like behavior and c-Fos expression in brainstem serotonergic neurons

Spiga, F., Lightman, SL., Shekhar, A. & Lowry, CA., Apr 2006, In : Neuroscience. 138 (4), p. 1265 - 1276 12 p.

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)
2005

Effects of urocortin 2 on behavior and c-Fos expression in topographically organized subpopulations of serotonergic neurons

Staub, D., Spiga, F. & Lowry, CA., 2005, In : Brain Research. 1044(2), p. 176 - 189 14 p.

Research output: Contribution to journalArticle (Academic Journal)