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Dr Gareth Jones

BSc, 1st class Hons, PhD

 https://orcid.org/0000-0002-0125-4841

  • BS8 1TD

20022020

Research output per year

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Personal profile

Research interests

I am a Versus Arthritis Career Development Fellow interested in understanding the immune mechanisms underpinning chronic inflammation and tissue damage. My group has examined how cytokines regulate the development, effector function and maintenance of immune cells within inflamed tissues, with a particular interest in the negative regulation of inflammation to restore immune homeostasis. This research has recently focused on how cytokines, primarily IL‑27, suppress the development and activity of ectopic lymphoid-like structures (also called tertiary lymphoid structures) across autoimmunity, infection and cancer. As a Versus Arthritis fellow, my research is geared towards identifying novel therapeutic targets and biomarkers of inflammatory arthritis pathology, thus linking fundamental mechanistic understanding with translational outcomes.

Find out more about the Jones Inflammation and Cytokines lab.

External positions

Honorary Senior Research Fellow, Thyroid Research Group, Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK.

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Projects

8049 - Understanding ectopic lymphoid structure development in the inflamed synovium-evaluating the prognostic and therapeutic potential of IL-27

Jones, G.

1/01/19 → 31/01/21

Project: Research

Research Output

  • 41 Article (Academic Journal)
  • 1 Chapter in a book

CD28− Cells Are Increased in Early Rheumatoid Arthritis and Are Linked With Cytomegalovirus Status

Thompson, C., Davies, R., Williams, A., Jones, G. & Choy, E. H. S., 5 May 2020, In : Frontiers in Medicine. 7, 6 p., 129.

Research output: Contribution to journal › Article (Academic Journal)

Open Access
File
    • 30 Downloads (Pure)

    Impaired IL-27 Mediated Control of CD4+ T Cell Function Impacts on Ectopic Lymphoid Structure Formation in Patients with Sjögren's Syndrome

    Lucchesi, D., Coleby, R., Pontarini, E., Prediletto, E., Rivellese, F., Hill, D. G., Derrac Soria, A., Jones, S. A., Humphreys, I. R., Sutcliffe, N., Tappuni, A. R., Pitzalis, C., Jones, G. W. & Bombardieri, M., 5 Apr 2020, (Accepted/In press) In : Arthritis and Rheumatology.

    Research output: Contribution to journal › Article (Academic Journal)

    • TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity

    Harbour, S. N., Ditoro, D. F., Witte, S. J., Zindl, C. L., Gao, M., Schoeb, T. R., Jones, G. W., Jones, S. A., Hatton, R. D. & Weaver, C. T., 17 Jul 2020, In : Science Immunology. 5, 49, p. eaaw2262

    Research output: Contribution to journal › Article (Academic Journal)

    Open Access
    File
    • 7 Downloads (Pure)