Projects per year
My research interests involve the application of bioinformatics to environmental genomics and crop Single Nucleotide Polymorphism (SNP) datasets. My interest in environmental genomics dates back to my PhD and postdoctoral work on gene flow in algae and cyanobacteria. In recent years I worked in collaboration with Keith Edwards group at Bristol to generate useful SNP markers for hexaploid bread wheat. I developed pipelines to mine inter-varietal SNPs from exome-capture sequence data and we went on to develop two commercial genotyping arrays from the ~1 million putative SNPs we found. These arrays are now used extensively by UK wheat breeders to rapidly screen new breeding lines at an early stage for markers linked to useful traits such as disease resistance and their impact has been to drastically reduce the time taken to naturally breed new wheat varieties. The advent of Next Generation Sequencing technology for DNA has made population-scale analysis of microbial communities tractable in recent years, which has enabled me to re-visit this area of my research. I currently have an EU-funded project to investigate micro-fouling of marine surfaces in which we are using high throughput sequencing for the identification of both taxa and genes associated with different anti-fouling compounds. I am also collaborating on projects using the similar techniques to study the microbial colonisation of retreating glacial fore-fields (in collaboration with Alex Anesio) and of humans who have received a nasal flu vaccine (in collaboration with Adam Finn). I am also working with Juliet Brodie at the Natural History Museum and Chris Yesson at the Institute of Zoology to develop genotyping by sequencing and novel sonar-based survey methods for UK kelps. I currently have a PhD vacancy funded by the EU to develop bioinformatics approaches to mine novel genes from cold environments.
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Designing Sustainable Wheat
1/04/23 → 31/03/28
Low cost DNA identification of crop varieties
1/02/21 → 31/01/23
Deigning Future Wheat ISP - WP4
1/04/17 → 31/03/23
Field assessment of genome-edited, low asparagine wheat: Europe's first CRISPR wheat field trialRaffan, S., Oddy, J., Mead, A., Barker, G., Curtis, T., Usher, S., Burt, C. & Halford, N. G., 26 May 2023, In: Plant Biotechnology Journal. 21, 6, p. 1097-1099 3 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access3 Citations (Scopus)
CerealsDB: A Whistle-Stop Tour of an Open Access SNP ResourceWinfield, M., Wilkinson, P., Burridge, A., Przewieslik-Allen, A., Coghill, J., Waterfall, C., Edwards, K. & Barker, G., 16 Jan 2022, Plant Bioinformatics. Humana Press, p. 133-146 14 p. (Methods in Molecular Biology; vol. 2443).
Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
The Use and Limitations of Exome Capture to Detect Novel Variation in the Hexaploid Wheat GenomeBurridge, A. J., Winfield, M. O., Wilkinson, P., Przewieslik-Allen, A. M., Edwards, K. J. & Barker, G. L. A., 12 Apr 2022, In: Frontiers in Plant Science. 13, 841855.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile32 Downloads (Pure)
Supporting information for "Flexible genes establish widespread bacteriophage pan-genomes in cryoconite hole ecosystems"
Bellas, C. M. (Contributor), Schroeder, D. C. (Contributor), Edwards, A. (Contributor), Barker, G. L. A. (Contributor) & Anesio, A. M. (Contributor), University of Aberystwyth, 14 Sep 2002
DOI: 10.20391/e56ec24d-9aed-4d60-8a8c-1118d9b04490, https://doi.org/10.20391%2Fe56ec24d-9aed-4d60-8a8c-1118d9b04490
Data from: Nonadditive changes to cytosine methylation as a consequence of hybridization and genome duplication in Senecio (Asteraceae)
Hegarty, M. J. (Contributor), Batstone, T. E. (Contributor), Barker, G. L. A. (Contributor), Edwards, K. J. (Contributor), Abbott, R. J. (Contributor) & Hiscock, S. J. (Contributor), Dryad, 8 Oct 2010
DOI: 10.5061/dryad.7851, http://datadryad.org/stash/dataset/doi:10.5061/dryad.7851