Projects per year
The overall goal of my research is to optimise the benefits of cardiac surgery on the heart and patient, while reducing the traumatic effects. Specific areas include:
Adult and Paediatric Cardiac Surgery
Clinical studies and trials to reduce myocardial injury and inflammation during adult cardiac surgery, and reperfusion injury in cyanotic children with congenital heart disease. We also try to reduce the inevitable adverse effects of surgical trauma and cardiopulmonary bypass, e.g. by comparing thoracotomy vs. sternotomy for off-pump coronary coronary artery bypass (OPCAB) surgery, warm vs. cold-blood cardioplegia in on-pump coronary and valve surgery, general anaesthesia with high thoracic epidural vs. general anaesthesia alone, and reduced vs. conventional cross-clamp time in combined coronary and valve surgery.
Angiogenesis and regenerative medicine
Using adult vascular progenitor cells, both for use as cardiovascular biomarkers, and for improving therapies in the clinic.
Carrying out preclinical studies and, subsequently, the first-in-man trials of drug gene-therapy and external stenting to treat vein graft stenosis.
Bioinspired artificial exosomes based on lipid nanoparticles carrying let-7b-5p promote angiogenesis in vitro and in vivoMadeddu, P. R., Emanueli, C., Aday, S., Hazan-Halevy, Chamorro-Jorganes, A., Anwar, M., Goldsmith, M., Beazley-Long, N., Sahoo, S., Dogra, N., Sweaad, W., Catapano, F., Ozaki-Tan, S., Angelini, G. D., Benest, A. & Peer, D., 2021, In: Mol Ther.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access
Co-culture of monocytes and zona fasciculata adrenal cells: An in vitro model to study the immune-adrenal cross-talkFudulu, D. P., Horn, G., Hazell, G. G. J., Anne-Marie Lefrancois-Martinez, Antoine Martinez, Angelini, G. D., Lightman, S. L. & Spiga, F., 15 Apr 2021, In: Molecular and Cellular Endocrinology. 526, 111195.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile9 Downloads (Pure)
Disparity in clinical outcomes after cardiac surgery between private and public (NHS) payers in EnglandBenedetto, U., Dimagli, A., Gibbison, B., Sinha, S., Pufulete, M., Fudulu, D., Cocomello, L., Bryan, A. J., Ohri, S., Caputo, M., Cooper, G., Dong, T., Akowuah, E. & Angelini, G. D., 1 Feb 2021, In: The Lancet Regional Health - Europe. 1, 8 p., 100003.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile11 Downloads (Pure)