Projects per year
The overall goal of my research is to optimise the benefits of cardiac surgery on the heart and patient, while reducing the traumatic effects. Specific areas include:
Adult and Paediatric Cardiac Surgery
Clinical studies and trials to reduce myocardial injury and inflammation during adult cardiac surgery, and reperfusion injury in cyanotic children with congenital heart disease. We also try to reduce the inevitable adverse effects of surgical trauma and cardiopulmonary bypass, e.g. by comparing thoracotomy vs. sternotomy for off-pump coronary coronary artery bypass (OPCAB) surgery, warm vs. cold-blood cardioplegia in on-pump coronary and valve surgery, general anaesthesia with high thoracic epidural vs. general anaesthesia alone, and reduced vs. conventional cross-clamp time in combined coronary and valve surgery.
Angiogenesis and regenerative medicine
Using adult vascular progenitor cells, both for use as cardiovascular biomarkers, and for improving therapies in the clinic.
Carrying out preclinical studies and, subsequently, the first-in-man trials of drug gene-therapy and external stenting to treat vein graft stenosis.
- 1 Similar Profiles
Dive into details
Select a country/territory to view shared publications and projects
Challenges and solutions to recruitment of neonates and children having cardiac surgery into a study using a novel sampling deviceWalker-Smith, T. A. F., Fudulu, D. P., Ramesh, A. V., Sheehan, K., Culliford, L. A., Evans, J., Angelini, G. D., Upton, T. J. & Gibbison, B. J. J., 11 Jun 2022, In: BMC Research Notes. 15, 1, 5 p., 202.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile6 Downloads (Pure)
Deep recurrent reinforced learning model to compare the efficacy of targeted local versus national measures on the spread of COVID-19 in the UKDong, T., Angelini, G. D., Fudulu, D. P., Benedetto, U., Sinha, S., Dimagli, A., Chan, J. & Caputo, M., 21 Feb 2022, In: BMJ Open. 12, 2, e048279.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile4 Downloads (Pure)
Effect of cardioplegic arrest and reperfusion on left and right ventricular proteome/phosphoproteome in patients undergoing surgery for coronary or aortic valve diseaseAbdul-Ghani, S., Skeffington, K. L., Kim, M., Moscarelli, M., Lewis, P. A., Heesom, K. J., Fiorentino, F., Emanueli, C., Reeves, B. C., Punjabi, P., Angelini, G. D. & Suleiman, M-S., 14 Apr 2022, (E-pub ahead of print) In: International Journal of Molecular Medicine. 49, 6, 14 p., 77.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile1 Citation (Scopus)28 Downloads (Pure)