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Research Output

2020
Open Access
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1 Citation (Scopus)
66 Downloads (Pure)

Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Brumpton, B., Sanderson, E., Heilbron, K., Hartwig, F. P., Harrison, S., Vie, G. Å., Cho, Y., Howe, L. D., Hughes, A., Boomsma, D. I., Havdahl, A., Hopper, J. L., Neale, M., Nivard, M. G., Pedersen, N. L., Reynolds, C., Tucker-Drob, E. M., Howe, L., Morris, T., Lin, S. & 14 others, The Within-family Consortium, the 23 and Me Research Team, Auton, A., Windmeijer, F., Chen, W-M., Bjørngaard, J. H., Hveem, K., Willer, C. J., Evans, D. M., Kaprio, J. A., Davey Smith, G., Åsvold, B. O., Hemani, G. & Davies, N. M., 14 Jul 2020, In : Nature Communications. 11, 13 p., 3519 (2020) .

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Downloads (Pure)

Bayesian reassessment of the epigenetic architecture of complex traits

Trejo Banos, D., McCartney, D. L., Patxot, M., Anchieri, L., Battram, T., Christiansen, C., Costeira, R., Walker, R. M., Morris, S. W., Campbell, A., Zhang, Q., Porteous, D. J., McRae, A. F., Wray, N. R., Visscher, P. M., Haley, C. S., Evans, K. L., Deary, I. J., McIntosh, A. M., Hemani, G. & 3 others, Bell, J. T., Marioni, R. E. & Robinson, M. R., 8 Jun 2020, In : Nature Communications. 11, 1, p. 2865

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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67 Downloads (Pure)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

Cho, Y., Haycock, P. C., Sanderson, E., Gaunt, T. R., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 21 Feb 2020, In : Nature Communications. 11, 13 p., 1010 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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50 Downloads (Pure)

Population phenomena inflate genetic associations of complex social traits

Morris, T. T., Davies, N. M., Hemani, G. & Davey Smith, G., 15 Apr 2020, In : Science Advances. 6, 16, 13 p., eaay0328.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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25 Downloads (Pure)

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

Zhao, Q., Wang, J., Hemani, G., Bowden, J. & Small, D. S., 17 Jul 2020, In : Annals of Statistics. 48, 3

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Downloads (Pure)

The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers

Reed, Z. E., Suderman, M. J., Relton, C. L., Davis, O. S. P. & Hemani, G., 30 Mar 2020, In : Clinical Epigenetics. 12, 50 (2020), 13 p., 50 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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23 Downloads (Pure)

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

Zheng, J., Brion, M-J. A., Kemp, J. P., Warrington, N. M., Borges, M. C., Hemani, G., Richardson, T. G., Rasheed, H., Qiao, Z., Haycock, P. C., Ala-Korpela, M. J., Davey Smith, G., Tobias, J. H. & Evans, D. M., 12 Mar 2020, In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle (Academic Journal)

2019

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

Richardson, T., Harrison, S., Hemani, G. & Davey Smith, G., 5 Mar 2019, In : eLife. 8, 24 p., e43657.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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23 Citations (Scopus)
218 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
197 Downloads (Pure)
Open Access
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3 Citations (Scopus)
11 Downloads (Pure)
Open Access
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37 Citations (Scopus)
280 Downloads (Pure)

Appraising the causal relevance of DNA methylation for risk of lung cancer

Battram, T., Richmond, R., Baglietto, L., Haycock, P., Perduca, V., Bojensen, S., Gaunt, T., Hemani, G., Guida, F., Carreras-Torres, R., Hung, R. J., Amos, C. I., Freeman, J., Sandanger, T. M., Nøst, T., Nordestgaard, B. G., Teschendorff, A. E., Polidoro, S., Vineis, P., Severi, G. & 7 others, Hodge, A., Giles, G. G., Grankvist, K., Johansson, M., Johansson, M., Davey Smith, G. & Relton, C., 24 Sep 2019, In : International Journal of Epidemiology. 12 p., dyz190.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
125 Downloads (Pure)

Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study

Periyasamy, S., John, S., Padmavati, R., Rajendren, P., Thirunavukkarasu, P., Gratten, J., Vinkhuyzen, A., McRae, A., Holliday, E. G., Nyholt, D. R., Nancarrow, D., Bakshi, A., Hemani, G., Nertney, D., Smith, H., Filippich, C., Patel, K., Fowdar, J., McLean, D., Tirupati, S. & 11 others, Nagasundaram, A., Gundugurti, P. R., Selvaraj, K., Jegadeesan, J., Jorde, L. B., Wray, N. R., Brown, M. A., Suetani, R., Giacomotto, J., Thara, R. & Mowry, B. J., 3 Jul 2019, In : JAMA Psychiatry.

Research output: Contribution to journalArticle (Academic Journal)

Open Access

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, Richardson, T. G., Yao, J., Fernandez, E. P., Ghanbari, M., Wojczynski, M. K., Lee, W. J., Argos, M., Armasu, S. M., Barve, R. A., Ryan, K. A., An, P., Baranski, T. J., Bielinski, S. J., Bowden, D. W., Broeckel, U., Christensen, K., Chu, A. Y., Corley, J., Cox, S. R., Uitterlinden, A. G., Rivadeneira, F., Cropp, C. D., Daw, E. W., van Heemst, D., de las Fuentes, L., Gao, H., Tzoulaki, I., Ahluwalia, T. S., de Mutsert, R., Emery, L. S., Erzurumluoglu, A. M., Perry, J. A., Fu, M., Forouhi, N. G., Gu, Z., Hai, Y., Harris, S. E., Hemani, G., Hunt, S. C., Irvin, M. R., Jonsson, A. E., Justice, A. E., Kerrison, N. D., Larson, N. B., Lin, K. H., Love-Gregory, L. D., Mathias, R. A., Lee, J. H., Nauck, M., Noordam, R., Ong, K. K., Pankow, J., Patki, A., Pattie, A., Petersmann, A., Qi, Q., Ribel-Madsen, R., Rohde, R., Sandow, K., Schnurr, T. M., Sofer, T., Starr, J. M., Taylor, A. M., Teumer, A., Timpson, N. J., de Haan, H. G., Wang, Y., Weeke, P. E., Williams, C., Wu, H., Yang, W., Zeng, D., Witte, D. R., Weir, B. S., Wareham, N. J., Vestergaard, H., Turner, S. T., Torp-Pedersen, C., Stergiakouli, E., Sheu, W. H. H., Rosendaal, F. R., Ikram, M. A., Franco, O. H., Ridker, P. M., Perls, T. T., Pedersen, O., Nohr, E. A., Newman, A. B., Linneberg, A., Langenberg, C., Kilpeläinen, T. O., Kardia, S. L. R., Jørgensen, M. E., Jørgensen, T., Sørensen, T., Homuth, G., Hansen, T., Goodarzi, M. O., Deary, I. J., Christensen, C., Chen, Y. D. I., Chakravarti, A., Brandslund, I., Bonnelykke, K., Taylor, K. D., Wilson, J. G., Rodriguez, S., Davies, G., Horta, B. L., Thyagarajan, B., Rao, D. C., Grarup, N., Davila-Roman, V. G., Hudson, G., Guo, X., Arnett, D. K., Hayward, C., Vaidya, D., Mook-Kanamori, D. O., Tiwari, H. K., Levy, D., Loos, R. J. F., Dehghan, A., Elliott, P., Malik, A. N., Scott, R. A., Becker, D. M., de Andrade, M., Province, M. A., Meigs, J. B., Rotter, J. I. & North, K. E., 3 Jan 2019, In : American Journal of Human Genetics. 104, 1, p. 112-138 27 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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14 Citations (Scopus)
287 Downloads (Pure)

Calculating Power to Detect Maternal and Offspring Genetic Effects in Genetic Association Studies

Moen, G. H., Hemani, G., Warrington, N. M. & Evans, D. M., 2 Jan 2019, In : Behavior Genetics. 49, 3, p. 327-339 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
72 Downloads (Pure)
11 Downloads (Pure)

Correction to: Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Lawson, D. J., Davies, N. M., Haworth, S., Ashraf, B., Howe, L., Crawford, A., Hemani, G., Davey Smith, G. & Timpson, N. J., 30 Jul 2019, In : Human Genetics. 2 p.

Research output: Contribution to journalArticle (Academic Journal)

118 Downloads (Pure)

Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate

Howe, L., Richardson, T., Arathimos, R., Alvizi, L., Passos-Bueno, M. R., Stanier, P., Nohr, E. A., Ludwig, K., Mangold, E., Knapp, M., Stergiakouli, E., St Pourcain, B., Davey Smith, G., Sandy, J., Relton, C., Lewis, S., Hemani, G. & Sharp, G., 1 Feb 2019, In : Epigenomics. 11, 2, p. 133-145 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
163 Downloads (Pure)

Genetic evidence for assortative mating on alcohol consumption in the UK Biobank

Howe, L. J., Lawson, D. J., Davies, N. M., St. Pourcain, B., Lewis, S. J., Davey Smith, G. & Hemani, G., 19 Nov 2019, In : Nature Communications. 10, 10 p., 5039 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
134 Downloads (Pure)

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

the 23 and Me Research Team, 4 Feb 2019, In : Nature Neuroscience. 22, 3, p. 343-352 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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121 Citations (Scopus)
227 Downloads (Pure)

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

eQTLGen Consortium, Timmers, P. R., Mounier, N., Lall, K., Fischer, K., Ning, Z., Feng, X., Bretherick, A. D. & Clark, D. W., 15 Jan 2019, In : eLife. 8

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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23 Citations (Scopus)
217 Downloads (Pure)

Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle

Taylor, D. L., Jackson, A. U., Narisu, N., Hemani, G., Erdos, M. R., Chines, P. S., Swift, A., Idol, J., Didion, J. P., Welch, R. P., Kinnunen, L., Saramies, J., Lakka, T. A., Laakso, M., Tuomilehto, J., Parker, S. C. J., Koistinen, H. A., Davey Smith, G., Boehnke, M., Scott, L. J. & 2 others, Birney, E. & Collins, F. S., 28 May 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 22, p. 10883-10888 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
138 Downloads (Pure)

Investigating the causal relationship between neuroticism and depression via Mendelian randomization

Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Apr 2019, In : Acta Psychiatrica Scandinavica. 139, 4, p. 395-397 3 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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4 Citations (Scopus)
37 Downloads (Pure)

Is Population Structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Lawson, D., Davies, N., Haworth, S., Ashraf, B., Howe, L., Crawford, A., Hemani, G., Davey Smith, G. & Timpson, N., 27 Apr 2019, In : Human Genetics. 19 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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180 Downloads (Pure)

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

EGG Consortium, May 2019, In : Nature Genetics. 51, 5, p. 804-814 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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34 Citations (Scopus)
230 Downloads (Pure)

Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

Ward-Caviness, C. K., S. de Vries, P., Davey Smith, G., Hartwig, F., Bowden, J., Hemani, G. & et al., 10 May 2019, In : PLoS ONE. 14, 5, 18 p., e0216222.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
169 Downloads (Pure)

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

eQTLGen Consortium & BIOS Consortium, 24 Jul 2019, In : Nature Communications. 10, 1, 12 p., 3300.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
290 Downloads (Pure)

MR-TRYX: Exploiting horizontal pleiotropy to infer novel causal pathways

Cho, Y., Haycock, P., Gaunt, T., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 2019, (Submitted) In : Nature Communications.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
95 Downloads (Pure)

Prenatal alcohol exposure and facial morphology in a UK cohort

Howe, L. J., Sharp, G. C., Hemani, G., Zuccolo, L., Richmond, S. & Lewis, S. J., 1 Apr 2019, In : Drug and Alcohol Dependence. 197, p. 42-47 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
65 Downloads (Pure)
Open Access
File
245 Downloads (Pure)
Open Access
File
2 Citations (Scopus)
224 Downloads (Pure)

Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis

ITALSGEN Consortium, 5 Apr 2019, In : Annals of Neurology. 85, 4, p. 470-481 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
18 Citations (Scopus)
24 Downloads (Pure)

Strengthening Causal Inference for Complex Disease Using Molecular Quantitative Trait Loci

Neumeyer, S., Hemani, G. & Zeggini, E., 9 Nov 2019, In : Trends in Molecular Medicine.

Research output: Contribution to journalReview article (Academic Journal)

The Parkinson’s Disease Mendelian Randomization Research Portal

Noyce, A. J., Bandres-Ciga, S., Kim, J., Helibron, K., Kia, D. A., Hemani, G., Xue, A., Lawlor, D. A., Davey Smith, G., Duran, R., Gan-Or, Z., Blauwendraat, C., Gibbs, J. R., Hinds, D. A., Yang, J., Visscher, P. M., Cuzick, J., Morris, H., Hardy, J., Wood, N. & 4 others, Nalls, M. A., Singleton, A. B., International Parkinson's Disease Genomics Consortium (IPDGC) & the 23 and Me Research Team, 17 Dec 2019, In : Movement Disorders. 34, 12, p. 1864 - 1872 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
105 Downloads (Pure)

Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies

Morris, A. P., Le, T. H., Wu, H., Akbarov, A., van der Most, P. J., Hemani, G., Smith, G. D., Mahajan, A., Gaulton, K. J., Nadkarni, G. N., Valladares-Salgado, A., Wacher-Rodarte, N., Mychaleckyj, J. C., Dueker, N. D., Guo, X., Hai, Y., Haessler, J., Kamatani, Y., Stilp, A. M., Zhu, G. & 52 others, Cook, J. P., Ärnlöv, J., Blanton, S. H., de Borst, M. H., Bottinger, E. P., Buchanan, T. A., Cechova, S., Charchar, F. J., Chu, P. L., Damman, J., Eales, J., Gharavi, A. G., Giedraitis, V., Heath, A. C., Ipp, E., Kiryluk, K., Kramer, H. J., Kubo, M., Larsson, A., Lindgren, C. M., Lu, Y., Madden, P. A. F., Montgomery, G. W., Papanicolaou, G. J., Raffel, L. J., Sacco, R. L., Sanchez, E., Stark, H., Sundstrom, J., Taylor, K. D., Xiang, A. H., Zivkovic, A., Lind, L., Ingelsson, E., Martin, N. G., Whitfield, J. B., Cai, J., Laurie, C. C., Okada, Y., Matsuda, K., Kooperberg, C., Chen, Y. D. I., Rundek, T., Rich, S. S., Loos, R. J. F., Parra, E. J., Cruz, M., Rotter, J. I., Snieder, H., Tomaszewski, M., Humphreys, B. D. & Franceschini, N., 3 Jan 2019, In : Nature Communications. 10, 14 p., 29.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
208 Downloads (Pure)

Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study

Carter, A., Gill, D., Davies, N., Taylor, A., Tillmann, T., Vaucher, J., Wootton, R., Munafo, M., Hemani, G., Malik, R., Seshadri, S., Woo, D., Burgess, S., Davey Smith, G., Holmes, M. V., Tzoulaki, I., Howe, L. & Dehghan, A., 22 May 2019, In : BMJ. 365, 12 p., l1855.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
325 Downloads (Pure)
1 Citation (Scopus)
Open Access
File
3 Citations (Scopus)
159 Downloads (Pure)
2018

Evaluating the potential role of pleiotropy in Mendelian randomization studies

Hemani, G., Bowden, J. & Davey Smith, G., 1 Aug 2018, In : Human Molecular Genetics. 27, R2, p. R195-R208 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
81 Citations (Scopus)
303 Downloads (Pure)

Genetic association of albuminuria with cardiometabolic disease and blood pressure

Haas, M. E., Aragam, K. G., Emdin, C., Bick, A. G., International Consortium for Blood Pressure Genome-Wide Association Studies, Hemani, G., Davey Smith, G. & Kathiresan, S., 4 Oct 2018, In : American Journal of Human Genetics. p. 461-473 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
28 Citations (Scopus)
235 Downloads (Pure)

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

eQTLGen Consortium, 27 Jul 2018, In : Nature Communications. 9, 14 p., 2941.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
70 Citations (Scopus)
310 Downloads (Pure)

Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability

Hysi, P. G., Valdes, A. M., Liu, F., Furlotte, N. A., Evans, D. M., Bataille, V., Visconti, A., Hemani, G., McMahon, G., Ring, S. M., Smith, G. D., Duffy, D. L., Zhu, G., Gordon, S. D., Medland, S. E., Lin, B. D., Willemsen, G., Jan Hottenga, J., Vuckovic, D., Girotto, G. & 24 others, Gandin, I., Sala, C., Concas, M. P., Brumat, M., Gasparini, P., Toniolo, D., Cocca, M., Robino, A., Yazar, S., Hewitt, A. W., Chen, Y., Zeng, C., Uitterlinden, A. G., Ikram, M. A., Hamer, M. A., Van Duijn, C. M., Nijsten, T., MacKey, D. A., Falchi, M., Boomsma, D. I., Martin, N. G., Hinds, D. A., Kayser, M. & Spector, T. D., 16 Apr 2018, In : Nature Genetics. 50, 5, p. 652-656 5 p.

Research output: Contribution to journalLetter (Academic Journal)

29 Citations (Scopus)

Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero

Warrington, N. M., Shevroja, E., Hemani, G., Hysi, P. G., Jiang, Y., Auton, A., Boer, C. G., Mangino, M., Wang, C. A., Kemp, J., McMahon, G., Medina-Gomez, C., Hickey, M., Trajanoska, K., Wolke, D., Ikram, M. A., Montgomery, G., Felix, J. F., Wright, M. J., Mackey, D. A. & 10 others, Jaddoe, V. W. V., Martin, N. G., Tung, J. Y., Davey Smith, G., Pennell, C. E., Spector, T. D., van Meurs, J. B. J., Rivadeneira, F., Medland, S. & Evans, D., 1 Jun 2018, In : Human Molecular Genetics. 27, 11, p. 2025-2038 14 p., ddy121.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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16 Citations (Scopus)
176 Downloads (Pure)

Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

Cuellar-Partida, G., Laurin, C., Ring, S., Gaunt, T., McRae, A., Visscher, P. M., Montgomery, G., Martin, N. G., Hemani, G., Suderman, M., Relton, C., Davey Smith, G. & Evans, D., Aug 2018, In : Human Molecular Genetics. 27, 16, p. 2927-2939 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
217 Downloads (Pure)