Dr Giulia Bigotti

Search results

• 2020

  Agrin-mediated cardiac regeneration: some open questions

  Bigotti, M. G., Skeffington, K. L., Jones, F. P., Caputo, M. & Brancaccio, A., 16 Jun 2020, In: Frontiers in Bioengineering and Biotechnology. 8, 8 p., 594.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Agrin
  • Cardiac Myocytes
  • Regeneration
  • Heart
  • Dystrophin
  38 Downloads (Pure)

• Changes in inflammation and oxidative stress signalling pathways in coarcted aorta triggered by bicuspid aortic valve and growth in young children

  Skeffington, K. L., Bond, A. R., Bigotti, M. G., Abdul Ghani, S., Iacobazzi, D., Kang, S., Heesom, K. J., Wilson, M. C., Stoica, S. C., Martin, R., Caputo, M., Suleiman, M-S. & Ghorbel, M., 3 Sep 2020, In: Experimental and Therapeutic Medicine. 20, 5, p. 48 10 p., 48.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Bicuspid Aortic Valve
  • Aortic Coarctation
  • Aorta
  • Tricuspid Valve
  • Oxidative Stress
  34 Downloads (Pure)

• Corrigendum: Agrin-Mediated Cardiac Regeneration: Some Open Questions

  Bigotti, M. G., Skeffington, K. L., Jones, F. P., Caputo, M. & Brancaccio, A., 2020, In: Frontiers in Bioengineering and Biotechnology. 8, p. 935

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Agrin
  • Regeneration

• Identification and modelling of a GT-A fold in the α-dystroglycan glycosylating enzyme LARGE1

  Righino, B., Bozzi, M., Pirolli, D., Sciandra, F., Bigotti, M. G., Brancaccio, A. & De Rosa, M. C., 22 Jun 2020, In: Journal of Chemical Information and Modeling. 60, p. 3145-3156 12 p., 6.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Dystroglycans
  • Enzymes
  • Disaccharides
  • Muscle
  • Proteins
  22 Downloads (Pure)
• 2019

  Analysis of α-dystroglycan/LG domain binding modes: investigating protein motifs that regulate the affinity of isolated LG domains

  Dempsey, C., Bigotti, M. G., Adams, J. & Brancaccio, A., 29 Mar 2019, In: Frontiers in Molecular Biosciences. 6, 19 p., 18.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Dystroglycans
  • Amino Acid Motifs
  • Laminin
  • Agrin
  • Calcium
  5 Citations (Scopus)

  215 Downloads (Pure)
• 2018

  Intraring allostery controls the function and assembly of a hetero-oligomeric class II chaperonin

  Shoemark, D., Sessions, R., Brancaccio, A. & Bigotti, M. G., Apr 2018, In: FASEB Journal. 32, 4, p. 2223-2234 12 p., fj.201701061R.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  File

  • Chaperonins
  • Thermoplasma
  • Adenosine Triphosphate
  • Archaea
  • Protein Folding
  253 Downloads (Pure)
• 2017

  Evaluation of the effect of a floxed Neo cassette within the dystroglycan (Dag1) gene

  Sciandra, F., Scicchitano, B. M., Signorino, G., Bigotti, M. G., Tavazzi, B., Lombardi, F., Bozzi, M., Sica, G., Giardina, B., Blaess, S. & Brancaccio, A., 21 Nov 2017, In: BMC Research Notes. 10, 8 p., 601.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Dystroglycans
  • Neomycin
  • Genes
  • Muscle
  • Skeletal Muscle
  1 Citation (Scopus)

  267 Downloads (Pure)

• Structural flexibility of human α-dystroglycan

  Covaceuszach, S., Bozzi, M., Bigotti, M. G., Sciandra, F., Konarev, P. V., Brancaccio, A. & Cassetta, A., Aug 2017, In: FEBS Open Bio. 7, 8, p. 1064-1077 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Dystroglycans
  • Crystal structure
  • Glycosylation
  • X ray scattering
  • Population distribution
  9 Citations (Scopus)

  268 Downloads (Pure)

• The effect of the pathological V72I, D109N and T190M missense mutations on the molecular structure of α-dystroglycan

  Covaceuszach, S., Bozzi, M., Bigotti, M. G., Sciandra, F., Konarev, P. V., Brancaccio, A. & Cassetta, A., 16 Oct 2017, In: PLoS ONE. 12, 10, 23 p., e0186110.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Dystroglycans
  • missense mutation
  • Molecular structure
  • Molecular Structure
  • Missense Mutation
  4 Citations (Scopus)

  272 Downloads (Pure)
• 2016

  Internal (His)₆-tagging delivers a fully functional hetero-oligomeric class II chaperonin in high yield

  Paul, D. M., Beuron, F., Sessions, R. B., Brancaccio, A. & Bigotti, G., 9 Feb 2016, In: Scientific Reports. 6, 10 p., 20696 (2016).

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Chaperonins
  • His-His-His-His-His-His
  • Group II Chaperonins
  • Archaea
  • Eukaryota
  2 Citations (Scopus)

  309 Downloads (Pure)
• 2015

  Genetic engineering of dystroglycan in animal models of muscular dystrophy

  Sciandra, F., Bigotti, M. G., Giardina, B., Bozzi, M. & Brancaccio, A., 24 Aug 2015, In: BioMed Research International. 2015, 10 p., 635792.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Animal Muscular Dystrophy
  • Genetic engineering
  • Dystroglycans
  • Genetic Engineering
  • Animals
  4 Citations (Scopus)

  395 Downloads (Pure)

• The structure of the T190M mutant of murine α-dystroglycan at high resolution: Insight into the molecular basis of a primary dystroglycanopathy

  Bozzi, M., Cassetta, A., Covaceuszach, S., Bigotti, M. G., Bannister, S., Hubner, W., Sciandra, F., Lamba, D. & Brancaccio, A., 1 May 2015, In: PLoS ONE. 10, 5, 21 p., e0124277.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Dystroglycans
  • mutation
  • muscular dystrophy
  • laminin
  • mutants
  10 Citations (Scopus)

  268 Downloads (Pure)
• 2013

  The multiple affinities of α-dystroglycan

  Sciandra, F., Bozzi, M., Bigotti, M. G. & Brancaccio, A., Nov 2013, In: Current Protein and Peptide Science. 14, 7, p. 626-34 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Dystroglycans
  • Ligands
  • Tissue
  • Laminin
  • Basement Membrane
  21 Citations (Scopus)
• 2012

  Insertion of a myc-tag within α-dystroglycan domains improves its biochemical and microscopic detection

  Morlacchi, S., Sciandra, F., Bigotti, M. G., Bozzi, M., Hübner, W., Galtieri, A., Giardina, B. & Brancaccio, A., 2012, In: BMC Biochemistry. 13, p. 14

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Dystroglycans
  • Molecules
  • Biochemistry
  • Cytology
  • Cell membranes
  12 Citations (Scopus)

  9 Downloads (Pure)
• 2008

  Chaperonins: The hunt for the Group II mechanism.

  Bigotti, M. G. & Clarke, A., Jun 2008, In: Archives of Biochemistry and Biophysics. 474, 2, p. 331-339

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  44 Citations (Scopus)
• 2006

  The asymmetric ATPase cycle of the thermosome: Eluciadation of the binding, hydrolysis and product-release steps

  Bigotti, MG., Bellamy, SRW. & Clarke, AR., Sep 2006, In: Journal of Molecular Biology. 362 (3), p. 835 - 843 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  19 Citations (Scopus)
• 2005

  Cooperativity in the thermosome

  Bigotti, MG. & Clarke, AR., Apr 2005, In: Journal of Molecular Biology. 348 (1), p. 13 - 26 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  41 Citations (Scopus)