Golam Khandaker

2025

Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts

Edmondson-Stait, A. J., Davyson, E., Shen, X., Adams, M. J., Khandaker, G. M., Miron, V. E., McIntosh, A. M., Lawrie, S. M., Kwong, A. S. F. & Whalley, H. C., 27 Jan 2025, In: European Psychiatry. 68, 1, e27.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Childhood Allergy and Anxiety/Depression in Early Adulthood: a longitudinal study in the ALSPAC birth cohort

Fairweather, S., Hammerton, G. L., Paternoster, L., Gilbody, S., Jones, H. J. & Khandaker, G., 1 Feb 2025, In: Brain, Behavior, and Immunity. 124, p. 226-236 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Levels

Corsi-Zuelli, F., Donohoe, G., Griffiths, S. L., Del-Ben, C. M., Watson, A. J., Burke, T., Lalousis, P. A., McKernan, D., Morris, D., Kelly, J., McDonald, C., Patlola, S. R., Pariante, C., Barnes, N. M., Khandaker, G. M., Suckling, J., Deakin, B., Upthegrove, R. & Dauvermann, M. R., 1 Mar 2025, In: Biological Psychiatry Global Open Science. 5, 2, 13 p., 100429.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Immunological Drivers and Potential Novel Drug Targets for Major Psychiatric, Neurodevelopmental, and Neurodegenerative Conditions

Dardani, C., Robinson, J. W., Jones, H. J., Rai, D., Stergiakouli , E., Grove, J., Gardner, R., Havdahl, K. A., Hemani, G., Davey Smith, G., Richardson, T. G., Gaunt, T. R. & Khandaker, G., 14 Mar 2025, In: Molecular Psychiatry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Inflammation proteomic profiling of psychosis in young adults: Findings from the ALSPAC birth cohort

Tsang, R., Timpson, N. J. & Khandaker, G., 1 Jan 2025, In: Psychoneuroendocrinology. 171, 107188.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Psychotic experiences and disorders in adolescents and young adults with borderline intellectual functioning and intellectual disabilities: Evidence from a population-based birth cohort in the United Kingdom

Dardani, C., Underwood, J. F. G., Jones, H. J., Rammos, A., Sullivan, S. A., Hull, L., Khandaker, G., Zammit, S., Rai, D. & Madley-Dowd, P. C., 5 Feb 2025, In: Psychological Medicine. 55, 8 p., e23.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Downloads (Pure)

Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort Study.

Slaney, C., Giollabhui, N. M., Hemani, G., Foley, É. M., Van der Most, P. J., Nolte, I. M., Snieder, H., Davey Smith, G., Khandaker, G. & Hartman, C. A., 1 Jan 2025, (Accepted/In press) In: Translational Psychiatry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2024

AI-based multimodal treatment response prediction in schizophrenia: combining inflammation and imaging

Lalousis, P. A., Curzon, A., Malaviya, A., Egerton, A., MacCabe, J., Mondelli, V., Drake, R., Walters, J., Lawrie, S., Griffiths, S. L., Rogers, J., Barnes, N., Deakin, B., Khandaker, G., Suckling, J. & Upthegrove, R., 20 Dec 2024, p. 560. 1 p.

Research output: Contribution to conference › Conference Abstract › peer-review

Open Access

A novel biomarker of interleukin 6 activity and clinical and cognitive outcomes in depression

Foley, É. M., Slaney, C., Donnelly, N., Kaser, M., Ziegler, L. & Khandaker, G., 1 Jun 2024, In: Psychoneuroendocrinology. 164, 10 p., 107008.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

6 Citations (Scopus)

Genomic insights into the comorbidity between type 2 diabetes and schizophrenia

Arruda, A. L., Khandaker, G. M., Morris, A. P., Smith, G. D., Huckins, L. M. & Zeggini, E., 21 Feb 2024, In: Schizophrenia (Heidelberg, Germany). 10, p. 22 22.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Identifying inflammation-related subgroups of psychopathology using machine learning

Fraser, H. & Khandaker, G., 20 Dec 2024, p. 111-112. 2 p.

Research output: Contribution to conference › Conference Abstract › peer-review

Open Access

Neuroinflammation in Comorbid Depression in Alzheimer’s Disease: a pilot study using post-mortem brain tissue.

Lin, J., Morisaki, M., Sampathkumar, S., Lau, L., Boche, D., Khandaker, G. & Sinclair, L. I., 3 Mar 2024, (E-pub ahead of print) In: Neuroscience Applied.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Positive and negative affect, related mental health traits, and cognitive performance: shared genetic architecture and potential causality

Slaney, C., Mac Giollabhui, N., Van der Most, P. J., Palacios, E. R., Snieder, H., Nivard, M. G., Hemani, G., Hartman, C. A. & Khandaker, G. M., 2 Nov 2024, medRxiv, 26 p.

Research output: Working paper › Preprint

File

8 Downloads (Pure)

The Insight Study: A randomised controlled trial of single-dose tocilizumab in patients with depression and low-grade inflammation

Foley, É. M., Parkinson, J., Oltean, B. & Khandaker, G., 20 Dec 2024.

Research output: Contribution to conference › Conference Abstract

Open Access

The relationship of within-individual and between-individual variation in mental health with bodyweight: An exploratory longitudinal study

Mueller, J., Ahern, A. L., Jones, R. A., Sharp, S. J., Davies, A., Zuckerman, A., Perry, B. I., Khandaker, G. M., Rolfe, E. D. L., Wareham, N. J., Rennie, K. L. & Ballarotto, G. (Editor), 10 Jan 2024, In: PLoS ONE. 19, 1, 18 p., e0295117.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

2023

Association between inflammation and cognition: triangulation of evidence using a population-based cohort and Mendelian randomization analyses

Slaney, C., Sallis, H. M., Jones, H. J., Dardani, C., Inflammation Working Group, C., Tilling, K., Munafò, M. R., Davey Smith, G., Mahedy, L. & Khandaker, G. M., 1 May 2023, In: Brain, Behavior, and Immunity. 110, p. 30-42 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

15 Citations (Scopus)

Comparison of the stability of Glycoprotein Acetyls and high sensitivity C-reactive protein as markers of chronic inflammation

Crick, D. C. P., Khandaker, G., Halligan, S. L., Burgner, D., Mansell, T. & Fraser, A., 26 Dec 2023, (E-pub ahead of print) In: Immunology. p. 1-16 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

6 Citations (Scopus)

Cytokines in psychosis: from mechanism towards treatment and prediction

Foley, É. M. & Khandaker, G. M., 27 Feb 2023, In: Lancet Psychiatry. 10, 4, p. 237-239 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

2 Citations (Scopus)

34 Downloads (Pure)

Glycoprotein acetyls and depression: Testing for directionality and potential causality using longitudinal data and Mendelian randomization analyses

Crick, D. C. P., Sanderson, E., Jones, H., Goulding, N., Borges, M. C., Clayton, G., Carter, A. R., Halligan, S., Lawlor, D. A., Khandaker, G. M. & Fraser, A., 15 Aug 2023, In: Journal of Affective Disorders. 335, p. 431-439 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis

PIMS Collaboration, 24 Mar 2023, In: BMJ Open. 13, 3, 10 p., e067944.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

7 Citations (Scopus)

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A mendelian randomisation study

Hamilton, F. W., Thomas, M., Arnold, D., Palmer, T., Moran, E., Mentzer, A. J., Maskell, N., Baillie, K., Summers, C., Hingorani, A., MacGowan, A., Khandaker, G. M., Mitchell, R., Davey Smith, G., Ghazal, P. & Timpson, N. J., 30 Jan 2023, In: PLoS Medicine. 20, 1, e1004174.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

71 Citations (Scopus)

2022

Association between common early-childhood infection and subsequent depressive symptoms and psychotic experiences in adolescence: a population-based longitudinal birth cohort study

Chaplin, A. B., Jones, P. B. & Khandaker, G. M., 1 Aug 2022, In: Psychological Medicine. p. 1-11 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

5 Citations (Scopus)

83 Downloads (Pure)

Associations between Adverse Childhood Experiences and the novel inflammatory marker glycoprotein acetyls in two generations of the Avon Longitudinal Study of Parents and Children birth cohort

Crick, D. C. P., Halligan, S. L., Howe, L. D., Lacey, R., Khandaker, G., Burgner, D., Herbert, A., Suderman, M. J., Anderson, E. L. & Fraser, A., Feb 2022, In: Brain, Behavior, and Immunity. 100, p. 112-120 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

8 Citations (Scopus)

141 Downloads (Pure)

Childhood Immuno-metabolic Markers and Risk of Depression and Psychosis in Adulthood: A Prospective Birth Cohort Study

Donnelly, N., Perry, B., Jones, H. J. & Khandaker, G., 1 May 2022, In: Psychoneuroendocrinology. 139, 11 p., 105707.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

1 Citation (Scopus)

66 Downloads (Pure)

Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age

Edmondson-Stait, A., Shen, X., Adams, M. J., Barbu, M. C., Jones, H. J., Miron, V. E., Allardyce, J., Boardman, J. P., Lawrie, S. M., McIntosh, A. M., Khandaker, G., Kwong, A. S. F. & Whalley, H. C., Dec 2022, In: Brain, Behavior, & Immunity - Health. 26, 100528.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

8 Citations (Scopus)

Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms

Kaser, M., Foley, É. M. & Khandaker, G. M., Feb 2022, In: Brain, Behavior, & Immunity - Health. 19, 10 p., 100409.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

10 Citations (Scopus)

148 Downloads (Pure)

Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis

Foley, É. M., Parkinson, J. T., Mitchell, R. E., Turner, L. & Khandaker, G. M., 28 Dec 2022, In: Molecular Psychiatry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

57 Citations (Scopus)

125 Downloads (Pure)

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: Findings from a Mendelian randomisation study

Hamilton, F. W., Thomas, M., Arnold, D. T., Palmer, T. M., Moran, E., Mentzer, A. J., Maskell, N. A., Baillie, J. K., Summers, C., Hingorani, A. D., MacGowan, A. P., Khandaker, G. M., Mitchell, R. E., Davey Smith, G., Ghazal, P. & Timpson, N. J., 15 Jul 2022, (E-pub ahead of print) p. 2022.07.14.22277638, (medRxiv).

Research output: Working paper › Preprint

2021

Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring: Findings From the Northern Finland Birth Cohort 1986

Ramsay, H., Surcel, H.-M., Björnholm, L., Kerkelä, M., Khandaker, G. M. & Veijola, J., 1 May 2021, In: Schizophrenia Bulletin. 10 p., sbaa152.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

8 Citations (Scopus)

88 Downloads (Pure)

Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study

Perry, B. I., Upthegrove, R., Kappelmann, N., Jones, P. B., Burgess, S. & Khandaker, G. M., Oct 2021, In: Brain, Behavior, and Immunity. 97, p. 176-185 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

102 Citations (Scopus)

98 Downloads (Pure)

Characteristics of inflammation-related depression

Foley, É. M., Parkinson, J., Kappelmann, N. & Khandaker, G., 2021, (Unpublished).

Research output: Contribution to conference › Conference Abstract

Childhood Inflammatory Markers and Risks for Psychosis and Depression at Age 24: examination of temporality and specificity of association in a population-based prospective birth cohort

Perry, B. I., Zammit, S., Jones, P. B. & Khandaker, G. M., 1 Apr 2021, In: Schizophrenia Research. 230, p. 69-76 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

27 Citations (Scopus)

176 Downloads (Pure)

Clinical phenotypes of depressed patients with evidence of inflammation

Foley, É. M., Parkinson, J., Kappelmann, N. & Khandaker, G., 2021, (Unpublished).

Research output: Contribution to conference › Conference Abstract

Clinical phenotypes of depressed patients with evidence of inflammation and somatic symptoms

Foley, É. M., Parkinson, J. T., Kappelmann, N. & Khandaker, G. M., 1 Nov 2021, In: Comprehensive Psychoneuroendocrinology. 8, 100079, p. 1-10 100079.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

19 Citations (Scopus)

146 Downloads (Pure)

Common Mechanisms for Type 2 Diabetes and Psychosis: Findings from a Prospective Birth Cohort

Perry, B., Jones, H. J., Richardson, T. G., Zammit, S., Wareham, N. J., Lewis, G., Jones, P. B. & Khandaker, G., 1 Sept 2021, In: Schizophrenia Research. 223, p. 227-235 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

10 Citations (Scopus)

61 Downloads (Pure)

Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort

Khandaker, G. M., Zuber, V., Rees, J. M. B., Carvalho, L., Mason, A. M., Foley, C. N., Gkatzionis, A., Jones, P. B. & Burgess, S., 1 Jul 2021, In: Molecular Psychiatry. (2020) 25, p. 1477-1486 4 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

5 Citations (Scopus)

84 Downloads (Pure)

Development and External Validation of The Psychosis Metabolic Risk Calculator (PsyMetRiC): A Cardiometabolic Risk Prediction Algorithm for Young People with Psychosis

Perry, B. I., Osimo, E. F., Upthegrove, R., Mallikarjun, P., Yorke, J., Stochl, J., Perez, J., Zammit, S., Howes, O., Jones, P. B. & Khandaker, G. M., Jul 2021, In: Lancet Psychiatry. 8, 7, p. 589-598 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

30 Citations (Scopus)

74 Downloads (Pure)

Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study

Kappelmann, N., Arloth, J., Georgakis, M. K., Czamara, D., Rost, N., Ligthart, S., Khandaker, G. M. & Binder, E. B., 1 Feb 2021, In: JAMA Psychiatry. 78, 2, p. 161-170 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

159 Citations (Scopus)

100 Downloads (Pure)

Fatigue in Depressed Patients with Evidence of Inflammation

Foley, É. M., Parkinson, J. T., Kappelmann, N. & Khandaker, G., 2021, (Unpublished).

Research output: Contribution to conference › Conference Abstract

Inflammation and Depression: A Public Health Perspective

Chu, A. L., Hickman, M., Steel, N., Jones, P., Davey Smith, G. & Khandaker, G., 1 Jul 2021, In: Brain, Behavior, and Immunity. 95, p. 1-3 3 p.

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

Open Access

File

29 Citations (Scopus)

125 Downloads (Pure)

Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies

Osimo, E., Baxter, L., Stochl, J., Perry, B., Metcalf, S., Kunutsor, S. K., Laukkanen, J., Wium-Andersen, M., Jones, P. & Khandaker, G., 28 May 2021, (E-pub ahead of print) In: npj Schizophrenia. 7, 9 p., 31 (2021).

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

29 Citations (Scopus)

62 Downloads (Pure)

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults

Perry, B. I., Stochl, J., Upthegrove, R., Zammit, S., Wareham, N., Langenberg, C., Winpenny, E., Dunger, D., Jones, P. B. & Khandaker, G. M., Apr 2021, In: JAMA Psychiatry. 78, 4, p. 416-425 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

50 Citations (Scopus)

91 Downloads (Pure)

Peripheral blood cellular immunophenotype in depression: A systematic review

Foley, É. M., Parkinson, J., Turner, L. & Khandaker, G., 2021, (Unpublished).

Research output: Contribution to conference › Conference Abstract

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study

CHARGE Inflammation Working Group, Jul 2021, In: Brain, Behavior, and Immunity. 95, p. 256-268 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

30 Citations (Scopus)

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

Ye, Z., Kappelmann, N., Moser, S., Davey Smith, G., Burgess, S., Jones, P. & Khandaker, G., 25 Jun 2021, (E-pub ahead of print) In: EClinicalMedicine. 38, 9 p., 100992.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

40 Citations (Scopus)

84 Downloads (Pure)

Stratification of adolescents across mental phenomena emphasizes the importance of transdiagnostic distress: a replication in two general population cohorts

Stochl, J., Jones, H., Soneson, E., Wagner, A. P., Khandaker, G. M., Zammit, S., Heron, J., Hammerton, G., Bullmore, E. T., Dolan, R., Fonagy, P., Goodyer, I. M., Perez, J. & Jones, P. B., 18 Nov 2021, (E-pub ahead of print) In: European Child and Adolescent Psychiatry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

1 Citation (Scopus)

44 Downloads (Pure)

2020

Assessment of the Role of IQ in Associations Between Population Density and Deprivation and Nonaffective Psychosis

Lewis, G., Dykxhoorn, J., Karlsson, H., Khandaker, G. M., Lewis, G., Dalman, C. & Kirkbride, J. B., 11 Mar 2020, In: JAMA Psychiatry. 77, 7, p. 729-736 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

13 Citations (Scopus)

76 Downloads (Pure)

Association between prenatal maternal infection and disordered eating behaviours in adolescence: a UK population-based prospective birth cohort study

Solmi, F., De Stavola, B. L., Khandaker, G. M., Bulik, C. M., Dalman, C. & Lewis, G., 2 May 2020, In: Psychological Medicine. 50, 6, p. 927-935 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

3 Citations (Scopus)

68 Downloads (Pure)

Cardiometabolic risk in young adults with depression and evidence of inflammation: A birth cohort study

Perry, B. I., Oltean, B. P., Jones, P. B. & Khandaker, G. M., 18 Apr 2020, In: Psychoneuroendocrinology. 116, p. 104682 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

12 Citations (Scopus)

69 Downloads (Pure)

Cardiometabolic risk prediction algorithms for young people with psychosis: a systematic review and exploratory analysis

Perry, B. I., Upthegrove, R., Crawford, O., Jang, S., Lau, E., McGill, I., Carver, E., Jones, P. B. & Khandaker, G. M., 29 Jul 2020, In: Acta Psychiatrica Scandinavica. 142, 3, p. 215-232 18 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

File

18 Citations (Scopus)

105 Downloads (Pure)

Professor Golam Khandaker

Research output

Search results