Golam Khandaker

2025

Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts

Edmondson-Stait, A. J., Davyson, E., Shen, X., Adams, M. J., Khandaker, G. M., Miron, V. E., McIntosh, A. M., Lawrie, S. M., Kwong, A. S. F. & Whalley, H. C., 27 Jan 2025, In: European Psychiatry. 68, 1, e27.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Blood immuno-metabolic biomarker signatures of depression and affective symptoms in young adults

Donnelly, N., Tsang, R., Foley, É. M., Fraser, H. A., Hanson, A. L. & Khandaker, G., 16 May 2025, In: Brain, Behavior, and Immunity. 128, p. 673-684 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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Childhood Allergy and Anxiety/Depression in Early Adulthood: a longitudinal study in the ALSPAC birth cohort

Fairweather, S., Hammerton, G. L., Paternoster, L., Gilbody, S., Jones, H. J. & Khandaker, G., 1 Feb 2025, In: Brain, Behavior, and Immunity. 124, p. 226-236 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Depression as a risk factor for Alzheimer’s disease: A human post-mortem study

Morisaki, M., Rezaali, F., Lau, L. C., Boche, D., Khandaker, G. M., Turecki, G., Sinclair, L. I. & Chen, M.-H. (Editor), 3 Apr 2025, In: PLoS ONE. 20, 4, 17 p., e0320561.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Levels

Corsi-Zuelli, F., Donohoe, G., Griffiths, S. L., Del-Ben, C. M., Watson, A. J., Burke, T., Lalousis, P. A., McKernan, D., Morris, D., Kelly, J., McDonald, C., Patlola, S. R., Pariante, C., Barnes, N. M., Khandaker, G. M., Suckling, J., Deakin, B., Upthegrove, R. & Dauvermann, M. R., 1 Mar 2025, In: Biological Psychiatry Global Open Science. 5, 2, 13 p., 100429.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Examining whether inflammation mediates effects of genetic risk and trauma on psychopathology

Lilford, P., Hammerton, G., Khandaker, G., Hall, J., Zammit, S. & Jones, H. J., 8 May 2025, (Accepted/In press) In: BJPsych Open.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Immunological Drivers and Potential Novel Drug Targets for Major Psychiatric, Neurodevelopmental, and Neurodegenerative Conditions

Dardani, C., Robinson, J. W., Jones, H. J., Rai, D., Stergiakouli , E., Grove, J., Gardner, R., Havdahl, K. A., Hemani, G., Davey Smith, G., Richardson, T. G., Gaunt, T. R. & Khandaker, G., 25 Apr 2025, (E-pub ahead of print) In: Molecular Psychiatry. 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

Inflammation proteomic profiling of psychosis in young adults: Findings from the ALSPAC birth cohort

Tsang, R., Timpson, N. J. & Khandaker, G., 1 Jan 2025, In: Psychoneuroendocrinology. 171, 107188.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Psychotic experiences and disorders in adolescents and young adults with borderline intellectual functioning and intellectual disabilities: Evidence from a population-based birth cohort in the United Kingdom

Dardani, C., Underwood, J. F. G., Jones, H. J., Rammos, A., Sullivan, S. A., Hull, L., Khandaker, G., Zammit, S., Rai, D. & Madley-Dowd, P. C., 5 Feb 2025, In: Psychological Medicine. 55, 8 p., e23.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Downloads (Pure)

Role of Inflammation in Depressive and Anxiety Disorders, Affect, and Cognition: Genetic and Non-Genetic Findings in the Lifelines Cohort Study

Slaney, C., Mac Giollabhui, N., Hemani, G., Foley, É. M., Van der Most, P. J., Nolte, I. M., Snieder, H., Davey Smith, G., Khandaker, G. & Hartman, C. A., 10 May 2025, In: Translational Psychiatry. 15, 1, 14 p., 164 .

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

The Relationship between Polyunsaturated Fatty Acids and Inflammation: Evidence from cohort and Mendelian randomization analyses

Crick, D. C. P., Halligan, S. L., Davey Smith, G., Khandaker, G. & Jones, H. J., 1 May 2025, (Accepted/In press) In: International Journal of Epidemiology.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2024

A novel biomarker of interleukin 6 activity and clinical and cognitive outcomes in depression

Foley, É. M., Slaney, C., Donnelly, N., Kaser, M., Ziegler, L. & Khandaker, G., 1 Jun 2024, In: Psychoneuroendocrinology. 164, 10 p., 107008.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

8 Citations (Scopus)

Genomic insights into the comorbidity between type 2 diabetes and schizophrenia

Arruda, A. L., Khandaker, G. M., Morris, A. P., Smith, G. D., Huckins, L. M. & Zeggini, E., 21 Feb 2024, In: Schizophrenia (Heidelberg, Germany). 10, p. 22 22.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Neuroinflammation in Comorbid Depression in Alzheimer’s Disease: a pilot study using post-mortem brain tissue.

Lin, J., Morisaki, M., Sampathkumar, S., Lau, L., Boche, D., Khandaker, G. & Sinclair, L. I., 3 Mar 2024, (E-pub ahead of print) In: Neuroscience Applied.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

The relationship of within-individual and between-individual variation in mental health with bodyweight: An exploratory longitudinal study

Mueller, J., Ahern, A. L., Jones, R. A., Sharp, S. J., Davies, A., Zuckerman, A., Perry, B. I., Khandaker, G. M., Rolfe, E. D. L., Wareham, N. J., Rennie, K. L. & Ballarotto, G. (Editor), 10 Jan 2024, In: PLoS ONE. 19, 1, 18 p., e0295117.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

2023

Association between inflammation and cognition: triangulation of evidence using a population-based cohort and Mendelian randomization analyses

Slaney, C., Sallis, H. M., Jones, H. J., Dardani, C., Inflammation Working Group, C., Tilling, K., Munafò, M. R., Davey Smith, G., Mahedy, L. & Khandaker, G. M., 1 May 2023, In: Brain, Behavior, and Immunity. 110, p. 30-42 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

18 Citations (Scopus)

Comparison of the stability of Glycoprotein Acetyls and high sensitivity C-reactive protein as markers of chronic inflammation

Crick, D. C. P., Khandaker, G., Halligan, S. L., Burgner, D., Mansell, T. & Fraser, A., 26 Dec 2023, (E-pub ahead of print) In: Immunology. p. 1-16 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

7 Citations (Scopus)

Cytokines in psychosis: from mechanism towards treatment and prediction

Foley, É. M. & Khandaker, G. M., 27 Feb 2023, In: Lancet Psychiatry. 10, 4, p. 237-239 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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2 Citations (Scopus)

33 Downloads (Pure)

Glycoprotein acetyls and depression: Testing for directionality and potential causality using longitudinal data and Mendelian randomization analyses

Crick, D. C. P., Sanderson, E., Jones, H., Goulding, N., Borges, M. C., Clayton, G., Carter, A. R., Halligan, S., Lawlor, D. A., Khandaker, G. M. & Fraser, A., 15 Aug 2023, In: Journal of Affective Disorders. 335, p. 431-439 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

4 Citations (Scopus)

Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis

PIMS Collaboration, 24 Mar 2023, In: BMJ Open. 13, 3, 10 p., e067944.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

7 Citations (Scopus)

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A mendelian randomisation study

Hamilton, F. W., Thomas, M., Arnold, D., Palmer, T., Moran, E., Mentzer, A. J., Maskell, N., Baillie, K., Summers, C., Hingorani, A., MacGowan, A., Khandaker, G. M., Mitchell, R., Davey Smith, G., Ghazal, P. & Timpson, N. J., 30 Jan 2023, In: PLoS Medicine. 20, 1, e1004174.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

74 Citations (Scopus)

2022

Association between common early-childhood infection and subsequent depressive symptoms and psychotic experiences in adolescence: a population-based longitudinal birth cohort study

Chaplin, A. B., Jones, P. B. & Khandaker, G. M., 1 Aug 2022, In: Psychological Medicine. p. 1-11 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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6 Citations (Scopus)

73 Downloads (Pure)

Associations between Adverse Childhood Experiences and the novel inflammatory marker glycoprotein acetyls in two generations of the Avon Longitudinal Study of Parents and Children birth cohort

Crick, D. C. P., Halligan, S. L., Howe, L. D., Lacey, R., Khandaker, G., Burgner, D., Herbert, A., Suderman, M. J., Anderson, E. L. & Fraser, A., Feb 2022, In: Brain, Behavior, and Immunity. 100, p. 112-120 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

138 Downloads (Pure)

Childhood Immuno-metabolic Markers and Risk of Depression and Psychosis in Adulthood: A Prospective Birth Cohort Study

Donnelly, N., Perry, B., Jones, H. J. & Khandaker, G., 1 May 2022, In: Psychoneuroendocrinology. 139, 11 p., 105707.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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1 Citation (Scopus)

69 Downloads (Pure)

Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age

Edmondson-Stait, A., Shen, X., Adams, M. J., Barbu, M. C., Jones, H. J., Miron, V. E., Allardyce, J., Boardman, J. P., Lawrie, S. M., McIntosh, A. M., Khandaker, G., Kwong, A. S. F. & Whalley, H. C., Dec 2022, In: Brain, Behavior, & Immunity - Health. 26, 100528.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

8 Citations (Scopus)

Neurocognitive Performance in Depressed Patients with low-grade inflammation and somatic symptoms

Kaser, M., Foley, É. M. & Khandaker, G. M., Feb 2022, In: Brain, Behavior, & Immunity - Health. 19, 10 p., 100409.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

144 Downloads (Pure)

Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis

Foley, É. M., Parkinson, J. T., Mitchell, R. E., Turner, L. & Khandaker, G. M., 28 Dec 2022, In: Molecular Psychiatry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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60 Citations (Scopus)

125 Downloads (Pure)

2021

Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring: Findings From the Northern Finland Birth Cohort 1986

Ramsay, H., Surcel, H.-M., Björnholm, L., Kerkelä, M., Khandaker, G. M. & Veijola, J., 1 May 2021, In: Schizophrenia Bulletin. 10 p., sbaa152.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

73 Downloads (Pure)

Associations of immunological proteins/traits with schizophrenia, major depression and bipolar disorder: A bi-directional two-sample mendelian randomization study

Perry, B. I., Upthegrove, R., Kappelmann, N., Jones, P. B., Burgess, S. & Khandaker, G. M., Oct 2021, In: Brain, Behavior, and Immunity. 97, p. 176-185 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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107 Citations (Scopus)

93 Downloads (Pure)

Childhood Inflammatory Markers and Risks for Psychosis and Depression at Age 24: examination of temporality and specificity of association in a population-based prospective birth cohort

Perry, B. I., Zammit, S., Jones, P. B. & Khandaker, G. M., 1 Apr 2021, In: Schizophrenia Research. 230, p. 69-76 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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27 Citations (Scopus)

177 Downloads (Pure)

Clinical phenotypes of depressed patients with evidence of inflammation and somatic symptoms

Foley, É. M., Parkinson, J. T., Kappelmann, N. & Khandaker, G. M., 1 Nov 2021, In: Comprehensive Psychoneuroendocrinology. 8, 100079, p. 1-10 100079.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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21 Citations (Scopus)

135 Downloads (Pure)

Common Mechanisms for Type 2 Diabetes and Psychosis: Findings from a Prospective Birth Cohort

Perry, B., Jones, H. J., Richardson, T. G., Zammit, S., Wareham, N. J., Lewis, G., Jones, P. B. & Khandaker, G., 1 Sept 2021, In: Schizophrenia Research. 223, p. 227-235 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

62 Downloads (Pure)

Correction: Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort

Khandaker, G. M., Zuber, V., Rees, J. M. B., Carvalho, L., Mason, A. M., Foley, C. N., Gkatzionis, A., Jones, P. B. & Burgess, S., 1 Jul 2021, In: Molecular Psychiatry. (2020) 25, p. 1477-1486 4 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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5 Citations (Scopus)

70 Downloads (Pure)

Development and External Validation of The Psychosis Metabolic Risk Calculator (PsyMetRiC): A Cardiometabolic Risk Prediction Algorithm for Young People with Psychosis

Perry, B. I., Osimo, E. F., Upthegrove, R., Mallikarjun, P., Yorke, J., Stochl, J., Perez, J., Zammit, S., Howes, O., Jones, P. B. & Khandaker, G. M., Jul 2021, In: Lancet Psychiatry. 8, 7, p. 589-598 10 p.

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31 Citations (Scopus)

62 Downloads (Pure)

Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study

Kappelmann, N., Arloth, J., Georgakis, M. K., Czamara, D., Rost, N., Ligthart, S., Khandaker, G. M. & Binder, E. B., 1 Feb 2021, In: JAMA Psychiatry. 78, 2, p. 161-170 10 p.

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161 Citations (Scopus)

86 Downloads (Pure)

Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies

Osimo, E., Baxter, L., Stochl, J., Perry, B., Metcalf, S., Kunutsor, S. K., Laukkanen, J., Wium-Andersen, M., Jones, P. & Khandaker, G., 28 May 2021, (E-pub ahead of print) In: npj Schizophrenia. 7, 9 p., 31 (2021).

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29 Citations (Scopus)

56 Downloads (Pure)

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults

Perry, B. I., Stochl, J., Upthegrove, R., Zammit, S., Wareham, N., Langenberg, C., Winpenny, E., Dunger, D., Jones, P. B. & Khandaker, G. M., Apr 2021, In: JAMA Psychiatry. 78, 4, p. 416-425 10 p.

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51 Citations (Scopus)

84 Downloads (Pure)

Polygenic risk for immuno-metabolic markers and specific depressive symptoms: A multi-sample network analysis study

CHARGE Inflammation Working Group, Jul 2021, In: Brain, Behavior, and Immunity. 95, p. 256-268 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

30 Citations (Scopus)

Role of Inflammation in Depression and Anxiety: Tests for Disorder Specificity, Linearity and Potential Causality of Association in the UK Biobank

Ye, Z., Kappelmann, N., Moser, S., Davey Smith, G., Burgess, S., Jones, P. & Khandaker, G., 25 Jun 2021, (E-pub ahead of print) In: EClinicalMedicine. 38, 9 p., 100992.

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Open Access

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42 Citations (Scopus)

83 Downloads (Pure)

Stratification of adolescents across mental phenomena emphasizes the importance of transdiagnostic distress: a replication in two general population cohorts

Stochl, J., Jones, H., Soneson, E., Wagner, A. P., Khandaker, G. M., Zammit, S., Heron, J., Hammerton, G., Bullmore, E. T., Dolan, R., Fonagy, P., Goodyer, I. M., Perez, J. & Jones, P. B., 18 Nov 2021, (E-pub ahead of print) In: European Child and Adolescent Psychiatry.

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Open Access

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1 Citation (Scopus)

32 Downloads (Pure)

2020

Assessment of the Role of IQ in Associations Between Population Density and Deprivation and Nonaffective Psychosis

Lewis, G., Dykxhoorn, J., Karlsson, H., Khandaker, G. M., Lewis, G., Dalman, C. & Kirkbride, J. B., 11 Mar 2020, In: JAMA Psychiatry. 77, 7, p. 729-736 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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13 Citations (Scopus)

70 Downloads (Pure)

Association between prenatal maternal infection and disordered eating behaviours in adolescence: a UK population-based prospective birth cohort study

Solmi, F., De Stavola, B. L., Khandaker, G. M., Bulik, C. M., Dalman, C. & Lewis, G., 2 May 2020, In: Psychological Medicine. 50, 6, p. 927-935 9 p.

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3 Citations (Scopus)

57 Downloads (Pure)

Cardiometabolic risk in young adults with depression and evidence of inflammation: A birth cohort study

Perry, B. I., Oltean, B. P., Jones, P. B. & Khandaker, G. M., 18 Apr 2020, In: Psychoneuroendocrinology. 116, p. 104682 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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12 Citations (Scopus)

58 Downloads (Pure)

Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records

Osimo, E. F., Perry, B. I., Cardinal, R. N., Lynall, M.-E., Lewis, J., Kudchadkar, A., Murray, G. K., Perez, J., Jones, P. B. & Khandaker, G. M., 17 Sept 2020, In: Brain, Behavior, and Immunity. 91, p. 117-127 11 p.

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Open Access

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18 Citations (Scopus)

52 Downloads (Pure)

Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood

Francesconi, M., Minichino, A., Khandaker, G. M., Midouhas, E., Lewis, G. & Flouri, E., 1 Jan 2020, In: Schizophrenia Research. 215 (2020), p. 424-429 6 p.

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Open Access

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6 Citations (Scopus)

155 Downloads (Pure)

Longitudinal Trends in Insulin Levels and BMI From Childhood and Their Associations with Risks of Psychosis and Depression in Young Adults

Perry, B. I., Stochl, J., Upthegrove, R., Zammit, S., Wareham, N., Langenberg, C., Winpenny, E., Dunger, D., Jones, P. B. & Khandaker, G. M., 11 Nov 2020, (Accepted/In press) In: JAMA Psychiatry.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort

Khandaker, G. M., Zuber, V., Rees, J. M. B., Carvalho, L., Mason, A. M., Foley, C. N., Gkatzionis, A., Jones, P. B. & Burgess, S., 1 Jul 2020, In: Molecular Psychiatry. 25, 7, p. 1477-1486 10 p.

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184 Citations (Scopus)

88 Downloads (Pure)

2019

Association between developmental milestones and age of schizophrenia onset: Results from the Northern Finland Birth Cohort 1966

Stochl, J., Whittier, A., Wagner, A. P., Veijola, J., Jääskeläinen, E., Miettunen, J., Khandaker, G. M. & Jones, P. B., Jun 2019, In: Schizophrenia Research. 208, p. 228-234 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

8 Citations (Scopus)

Commentary: Causal associations between inflammation, cardiometabolic markers and schizophrenia: the known unknowns

Khandaker, G. M., 1 Oct 2019, In: International Journal of Epidemiology. 48, 5, p. 1516-1518 3 p.

Research output: Contribution to journal › Article (Academic Journal)

8 Citations (Scopus)

Dysglycaemia, Inflammation and Psychosis: Findings from the UK ALSPAC Birth Cohort

Perry, B. I., Upthegrove, R., Thompson, A., Marwaha, S., Zammit, S., Singh, S. P. & Khandaker, G., 7 Mar 2019, In: Schizophrenia Bulletin. 45, 2, p. 330-338 9 p.

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36 Citations (Scopus)

237 Downloads (Pure)

Professor Golam Khandaker

Research output

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