Projects per year
Our research is aimed at understanding the lethality of opioid drugs such as heroin, methadone and fentanyl in opioid overdose and how their lethality (through depression of respiration) can be enhanced by other drugs such as alcohol and gabapentinoids.
Prolonged use of opioids results in the development of tolerance whereby the effect of the drug (euphoria or respiratory depression) is reduced and more drug must be taken to induce the original level of effect. We have demonstrated that the mechanisms underlying tolerance may be different for different opioids and that alcohol and gabapentinoids lower heroin but not methadone tolerance.
We use a reverse translational approach whereby we interview heroin users to find out their views on the dangers of opioid overdose and how that may be altered by other drugs. We then perform controlled laboratory experiments to examine the cellular mechanisms underlying such interactions.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Dive into details
Select a country/territory to view shared publications and projects
Opioid overdose deaths: Understanding the lethal interactions between benzodiazepines and opioids to develop new harm reduction strategies
1/07/22 → 30/06/25
Project: Research, Parent
Kelly, E., Conibear, A. & Henderson, G., 2023, In: Annual review of pharmacology and toxicology. 63, p. 491-515 25 p.
Research output: Contribution to journal › Review article (Academic Journal) › peer-reviewOpen Access13 Citations (Scopus)
Ramos-Gonzalez, N., Groom, S., Sutcliffe, K. J., Bancroft, S., Bailey, C. P., Sessions, R. B., Henderson, G. & Kelly, E., 2 Apr 2023, (E-pub ahead of print) In: British Journal of Pharmacology. 180, 18, p. 2341-2360 20 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access1 Citation (Scopus)
Comparison of the effects of fentanyls and other μ opioid receptor agonists on the electrical activity of respiratory muscles in the ratCavallo, D., Kelly, E. P., Henderson, G. & Abdala Sheikh, A. P., 23 Nov 2023, In: Frontiers in Pharmacology. 14, 1277248.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access
- 2 Editorial activity