Projects per year
Our research is aimed at understanding the lethality of opioid drugs such as heroin, methadone and fentanyl in opioid overdose and how their lethality (through depression of respiration) can be enhanced by other drugs such as alcohol and gabapentinoids.
Prolonged use of opioids results in the development of tolerance whereby the effect of the drug (euphoria or respiratory depression) is reduced and more drug must be taken to induce the original level of effect. We have demonstrated that the mechanisms underlying tolerance may be different for different opioids and that alcohol and gabapentinoids lower heroin but not methadone tolerance.
We use a reverse translational approach whereby we interview heroin users to find out their views on the dangers of opioid overdose and how that may be altered by other drugs. We then perform controlled laboratory experiments to examine the cellular mechanisms underlying such interactions.
1/04/19 → 31/12/21
A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic painConibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 20 Jan 2020, In: Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 224-236 13 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile88 Downloads (Pure)
A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitization through G protein-coupled receptor kinaseGroom, S., Blum, N. K., Conibear, A. E., Disney, A., Hill, R., Husbands, S. M., Li, Y., Toll, L., Kliewer, A., Schulz, S., Henderson, G., Kelly, E. & Bailey, C. P., 27 Nov 2020, (E-pub ahead of print) In: British Journal of Pharmacology.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Kelly, E., Henderson, G., Christie, M. J., Schulz, S. & Canals, M., 1 Dec 2020, In: Trends in Pharmacological Sciences. 41, 12, p. 947-959 13 p.
Research output: Contribution to journal › Review article (Academic Journal) › peer-reviewOpen AccessFile27 Downloads (Pure)