Professor Graeme Henderson

B.Sc.(Glas.), MA, Ph.D.(Aberd.), Hon FBPhS, FRSB

Professor of Pharmacology, School of Physiology, Pharmacology & Neuroscience
Bristol Neuroscience

EmailGraeme.Henderson@bristol.ac.uk

BS8 1TD

Research output per year

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Personal profile

Research interests

Our research is aimed at understanding the lethality of opioid drugs such as heroin, methadone and fentanyl in opioid overdose and how their lethality (through depression of respiration) can be enhanced by other drugs such as alcohol and gabapentinoids.

Prolonged use of opioids results in the development of tolerance whereby the effect of the drug (euphoria or respiratory depression) is reduced and more drug must be taken to induce the original level of effect. We have demonstrated that the mechanisms underlying tolerance may be different for different opioids and that alcohol and gabapentinoids lower heroin but not methadone tolerance.

We use a reverse translational approach whereby we interview heroin users to find out their views on the dangers of opioid overdose and how that may be altered by other drugs. We then perform controlled laboratory experiments to examine the cellular mechanisms underlying such interactions.

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Projects

2 Finished
3 Active

Fentanyl Overdose Deaths: Under - Collaboration Agreement - University of Nottingham

Henderson, G.

1/04/19 → 31/12/21

Project: Research

Fentanyl Overdose Deaths: Underlying Mechanisms

Henderson, G.

1/04/19 → 31/03/22

Project: Research

Fentanyl Overdose Deaths: Underlying Mechanisms

Henderson, G.

1/07/14 → …

Project: Research, Parent

Research Output

53 Article (Academic Journal)
2 Editorial (Academic Journal)
2 Letter (Academic Journal)

A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain

Conibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 20 Jan 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 224-236 13 p.

Research output: Contribution to journal › Article (Academic Journal)

Open Access

File

86 Downloads (Pure)

Morphine-induced respiratory depression is independent of β-arrestin2 signalling

Kliewer, A., Gillis, A., Hill, R., Schmidel, F., Bailey, C., Kelly, E., Henderson, G., Christie, M. J. & Schulz, S., 12 Feb 2020, In : British Journal of Pharmacology.

Research output: Contribution to journal › Article (Academic Journal)

Open Access

File