Professor Graeme Henderson

B.Sc.(Glas.), MA, Ph.D.(Aberd.), Hon FBPhS, FRSB

  • BS8 1TD

1994 …2020

Research output per year

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Research Output

  • 53 Article (Academic Journal)
  • 2 Editorial (Academic Journal)
  • 2 Letter (Academic Journal)
2020

A novel G protein-biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain

Conibear, A. E., Asghar, J., Hill, R., Henderson, G., Borbely, E., Tekus, V., Helyes, Z., Palandri, J., Bailey, C., Starke, I., von Mentzer, B., Kendall, D. & Kelly, E., 20 Jan 2020, In : Journal of Pharmacology and Experimental Therapeutics. 372, 2, p. 224-236 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
73 Downloads (Pure)

Morphine-induced respiratory depression is independent of β-arrestin2 signalling

Kliewer, A., Gillis, A., Hill, R., Schmidel, F., Bailey, C., Kelly, E., Henderson, G., Christie, M. J. & Schulz, S., 12 Feb 2020, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
22 Downloads (Pure)

Synthetic cannabinoids and potential cardiac arrhythmia risk: an important message for drug users

Hancox, J. C., Kalk, N. J. & Henderson, G., 24 Mar 2020, In : Therapeutic Advances in Drug Safety. 11, 4 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
20 Downloads (Pure)
2019

Fentanyl depression of respiration: comparison with heroin and morphine

Hill, R., Santhakumar, R., Dewey, W., Kelly, E. & Henderson, G., 9 Sep 2019, In : British Journal of Pharmacology. 41 p.

Research output: Contribution to journalArticle (Academic Journal)

Global patterns of opioid use and dependence: harms to populations, interventions, and future action

Degenhardt, L., Grebely, J., Stone, J., Hickman, M., Vickerman, P., Marshall, B. D. L., Bruneau, J., Altice, F. L., Henderson, G., Rahimi-Movaghar, A. & Larney, S., 26 Oct 2019, In : The Lancet. 394, 10208, p. 1560-1579 20 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
97 Downloads (Pure)

How the complex pharmacology of the fentanyls contributes to their lethality

Henderson, G., Kelly, E. & Gill, H., 17 Apr 2019, In : Addiction. 2 p.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
File
4 Citations (Scopus)
152 Downloads (Pure)

Prolonged ethanol administration prevents the development of tolerance to morphine-induced respiratory depression

Hill, R., Roberts, J., Maclachlan, J., Dewey, W., Kelly, E. & Henderson, G., 1 Dec 2019, In : Drug and Alcohol Dependence. 205, 8 p., 107674.

Research output: Contribution to journalArticle (Academic Journal)

2018

A new approach to formulating and appraising drug policy: A multi-criterion decision analysis applied to alcohol and cannabis regulation

Rogeberg, O., Bergsvik, D., Phillips, L. D., van Amsterdam, J., Eastwood, N., Henderson, G., Lynskey, M., Measham, F., Ponton, R., Rolles, S., Schlag, A. K., Taylor, P. & Nutt, D., Jun 2018, In : International Journal of Drug Policy. 56, p. 144-152 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
179 Downloads (Pure)

Emerging areas of opioid pharmacology

Kelly, E., Henderson, G. & Bailey, C. P., 1 Jul 2018, In : British Journal of Pharmacology. 175, 14, p. 2715-2716 2 p.

Research output: Contribution to journalEditorial (Academic Journal)

Ethanol reversal of oxycodone tolerance in dorsal root ganglia neurons

Jacob, J. C., Sakakibara, K., Mischel, R. A., Henderson, G., Dewey, W. L. & Akbarali, H. I., 1 May 2018, In : Molecular Pharmacology. 93, 5, p. 417-426 10 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition

Hill, R., Dewey, W. L., Kelly, E. & Henderson, G., Jun 2018, In : British Journal of Pharmacology. 175, 12, p. 2492-2503 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
181 Downloads (Pure)

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

Hill, R., Disney, A., Conibear, A., Sutcliffe, K., Dewey, W., Husbands, S., Bailey, C., Kelly, E. & Henderson, G., 15 Jul 2018, In : British Journal of Pharmacology. 175, 13, p. 2653-2661 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
48 Citations (Scopus)
307 Downloads (Pure)
2017

Comparison of cannabinoids in hair with self-reported cannabis consumption in heavy, light, and non- cannabis users

Taylor, M., Lees, R. J., Henderson, G., Lingford-Hughes, A. R., Macleod, J. A. A., Sullivan, J. & Hickman, M., Mar 2017, In : Drug and Alcohol Review. 36, 2, p. 220-226 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
22 Citations (Scopus)
223 Downloads (Pure)

Drug binding poses relate structure with efficacy in the μ opioid receptor

Sutcliffe, K. J., Henderson, G., Kelly, E. & Sessions, R. B., 16 Jun 2017, In : Journal of Molecular Biology. 429, 12, p. 1840-1851 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
270 Downloads (Pure)
11 Citations (Scopus)

Ethanol Reversal of Tolerance to the Antinociceptive Effects of Oxycodone and Hydrocodone

Jacob, J. C., Poklis, J. L., Akbarali, H. I., Henderson, G. & Dewey, W. L., Jul 2017, In : Journal of Pharmacology and Experimental Therapeutics. 362, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle (Academic Journal)

File
9 Citations (Scopus)
205 Downloads (Pure)

Reversal of oxycodone and hydrocodone tolerance by diazepam

Gonek, M., Akbarali, H. I., Henderson, G. & Dewey, W. L., 1 Nov 2017, In : Brain Research. 1674, p. 84-90 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
275 Downloads (Pure)

Risk to heroin users of poly-drug use of pregabalin or gabapentin

Lyndon, A., Audrey, S., Wells, C., Burnell, E., Ingle, S., Hill, R., Hickman, M. & Henderson, G., Sep 2017, In : Addiction. 112, 9, p. 1580-1589 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
47 Citations (Scopus)
371 Downloads (Pure)
2016

Ketamine - the real perspective

Taylor, P., Nutt, D., Curran, V., Fortson, R., Henderson, G. & DrugScience, 26 Mar 2016, In : Lancet. 387, 10025, p. 1271-1272 2 p.

Research output: Contribution to journalLetter (Academic Journal)

4 Citations (Scopus)
2015

Ethanol Reversal of Tolerance to the Respiratory Depressant Effects of Morphine

Hill, R., Lyndon, A., Withey, S., Roberts, J., Kershaw, Y., MacLachlan, J., Lingford-Hughes, A., Kelly, E., Bailey, C., Hickman, M. & Henderson, G., 9 Sep 2015, In : Neuropsychopharmacology.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Ranking the harm of non-medically used prescription opioids in the UK

van Amsterdam, J., Phillips, L., Henderson, G., Bell, J., Bowden-Jones, O., Hammersley, R., Ramsey, J., Taylor, P., Dale-Perera, A., Melichar, J., van den Brink, W. & Nutt, D., 14 Sep 2015, In : Regulatory Toxicology and Pharmacology. 73, 3, p. 999-7004 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
341 Downloads (Pure)

Reply to Wang and Sadée

Henderson, G. & Bullmore, E. T., 11 Mar 2015, In : Psychopharmacology.

Research output: Contribution to journalArticle (Academic Journal)

Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Lowe, J. D., Sanderson, H. S., Cooke, A. E., Ostovar, M., Tsisanova, E., Withey, S. L., Chavkin, C., Husbands, S. M., Kelly, E., Henderson, G. & Bailey, C. P., 26 May 2015, In : Molecular Pharmacology.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)
2014

Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor

Cooke, A. E., Oldfield, S., Krasel, C., Mundell, S. J., Henderson, G. & Kelly, E., 4 Apr 2014, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours

Kelly, E., Mundell, S. J., Sava, A., Roth, A. L., Felici, A., Maltby, K., Nathan, P. J., Bullmore, E. T. & Henderson, G., 29 Jun 2014, In : Psychopharmacology.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

The μ-opioid receptor: an electrophysiologist's perspective from the sharp end

Henderson, G., 15 Feb 2014, In : British Journal of Pharmacology.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
2013

Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons

Llorente, J., Withey, S., Rivero, G., Cunningham, M., Cooke, A., Saxena, K., McPherson, J., Oldfield, S., Dewey, W. L., Bailey, C. P., Kelly, E. & Henderson, G., Aug 2013, In : Molecular Pharmacology. 84, 2, p. 252-60 9 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor

Chen, Y-J., Oldfield, S., Butcher, A. J., Tobin, A. B., Saxena, K., Gurevich, V. V., Benovic, J. L., Henderson, G. & Kelly, E., Jan 2013, In : Journal of Neurochemistry. 124, 2, p. 189-199 11 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance

Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J. & Christie, M. J., Jan 2013, In : Pharmacological Reviews. 65, 1, p. 223-54 32 p.

Research output: Contribution to journalArticle (Academic Journal)

354 Citations (Scopus)

Reversal of Morphine Analgesic Tolerance by Ethanol in the Mouse

Hull, L. C., Gabra, B. H., Bailey, C. P., Henderson, G. & Dewey, W. L., 25 Mar 2013, In : Journal of Pharmacology and Experimental Therapeutics.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)
2012

Comparison of Ethyl Glucuronide in Hair with Self-Reported Alcohol Consumption

Lees, R. J., Kingston, R., Williams, T. M., Henderson, G., Lingford-Hughes, A. & Hickman, M., 2012, In : Alcohol and Alcoholism. 47, 3, p. 267-272 6 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Endocytosis of G protein-coupled receptors is regulated by clathrin light chain phosphorylation

Ferreira, F., Foley, M., Cooke, A., Cunningham, M., Smith, G., Woolley, R., Henderson, G., Kelly, E., Mundell, S. & Smythe, E., Aug 2012, In : Current Biology. 22, 15, p. 1361-70 10 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Endomorphin-2: A Biased Agonist at the μ Opioid Receptor

Rivero, G., Llorente, J., McPherson, J., Cooke, A., Mundell, S. J., McArdle, C. A., Rosethorne, E. M., Charlton, S. J., Krasel, C., Henderson, G. & Kelly, E., Aug 2012, In : Molecular Pharmacology. 82, 2, p. 178-188 11 p.

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)

Enhancement of μ-opioid receptor desensitization by nitric oxide in rat locus coeruleus neurons: involvement of reactive oxygen species

Llorente, J., Santamarta, M. T., Henderson, G. & Pineda, J., 2012, In : Journal of Pharmacology and Experimental Therapeutics. 342, 2, p. 552-60 9 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

μ-Opioid receptor desensitization: homologous or heterologous?

Llorente, J., Lowe, J. D., Sanderson, H. S., Tsisanova, E., Kelly, E. P., Henderson, G. & Bailey, C. P., 2012, In : European Journal of Neuroscience.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)
2010

The effect of protein kinase C and G protein-coupled receptor kinase inhibition on tolerance induced by mu-opioid agonists of different efficacy

Hull, L. C., Llorente, J., Gabra, B. H., Smith, F. L., Kelly, E., Bailey, C., Henderson, G. & Dewey, W. L., Mar 2010, In : Journal of Pharmacology and Experimental Therapeutics. 332, p. 1127 - 1135 8 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

μ-Opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization

McPherson, J. L., Rivero, G., Baptist, M. C., Llorente, F. J., Al-Sabah, S., Krasel, C., Dewey, W. L., Bailey, CP., Rosethorne, E. M., Charlton, S. J., Henderson, G. & Kelly, E., Oct 2010, In : Molecular Pharmacology. 78, 4, p. 756 - 766 11 p.

Research output: Contribution to journalArticle (Academic Journal)

164 Citations (Scopus)
2009

Involvement of PKCalpha and G-protein-coupled receptor kinase 2 in agonist-selective desensitization of micro-opioid receptors in mature brain neurons

Bailey, C. P., Oldfield, S., Llorente, F. J., Caunt, C. J., Teschemacher, A. G., Roberts, L., McArdle, C. A., Smith, F. L., Dewey, W. L., Kelly, E. & Henderson, G., Sep 2009, In : British Journal of Pharmacology. 158, 1, p. 157 - 164 8 p.

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)

Role of protein kinase C and μ-opioid receptor (MOPr) desensitization in tolerance to morphine in rat locus coeruleus neurons

Bailey, CP., Llorente, FJ., Gabra, BH., Smith, FL., Dewey, WL., Kelly, E. & Henderson, G., Jan 2009, In : European Journal of Neuroscience. 29, 2, p. 307 - 318 12 p.

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)
2008

Agonist-selective mechanisms of GPCR desensitization

Kelly, E. P., Bailey, C. P. & Henderson, G., 2008, In : British Journal of Pharmacology. 153, p. S379-S388 10 p.

Research output: Contribution to journalArticle (Academic Journal)

255 Citations (Scopus)

Does alcohol increase the risk of overdose death: the need for a translational approach

Hickman, M., Lingford-Hughes, A., Bailey, C., Macleod, J. A. A., Nutt, D. & Henderson, G., Jul 2008, In : Addiction. 103, 7, p. 1060-1062 3 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Methadone: does it really have low efficacy at µ-opioid receptors?

Rodriguez-Martin, I., Braksator, E., Bailey, C. P., Goodchild, S., Marrion, NV. & Henderson, G., 2008, In : NeuroReport. 19, p. 589 - 593

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice

Gabra, B. H., Bailey, C. P., Kelly, E., Smith, F. L., Henderson, G. & Dewey, W. L., Jun 2008, In : Brain Research. 1217, p. 70 - 77 7 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Terminal splice variants of the µ-opioid receptor (MOPr): existence, distribution and functional characteristics

Oldfield, S., Braksator, E., Rodriguez-Martin, I., Bailey, C. P., Donaldson, LF., Henderson, G. & Kelly, E., Feb 2008, In : Journal of Neurochemistry. 104(4), p. 937 - 945 9 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)
2006

75 years of opioid research: the exciting but vain quest for the Holy Grail

Corbett, AD., Henderson, G., McKnight, AT. & Patterson, SJ., Jan 2006, In : British Journal of Pharmacology. 147 (Suppl 1), p. S153 - S162 10 p.

Research output: Contribution to journalArticle (Academic Journal)

207 Citations (Scopus)

Agonist-Selective Mechanisms of μ-Opioid Receptor Desensitization in Human Embryonic Kidney 293 Cells

Johnson, EA., Oldfield, S., Braksator, E., Gonzalez-Cuello, A., Couch, D., Hall, KJ., Mundell, SJ., Bailey, CP., Kelly, E. & Henderson, G., Aug 2006, In : Molecular Pharmacology. 70 (2), p. 676 - 685 10 p.

Research output: Contribution to journalArticle (Academic Journal)

123 Citations (Scopus)

Pharmacology: what is it and how is it important to the health and wealth of the UK?

Page, C., Buckingham, J., Henderson, G. & Hill, RG., Mar 2006, In : Science in Parliament. 63 (1), p. 30 - 31 2 p.

Research output: Contribution to journalArticle (Academic Journal)

The British Pharmacological Society: 75 years old and thriving

Henderson, G., Mar 2006, In : Trends in Pharmacological Sciences. 27 (3), p. 122 - 124 3 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
2005

Drug abuse: from gene through cell to behaviour

Henderson, G., Morton, J. & Little, HJ., Feb 2005, In : Current Opinion in Pharmacology. 5 (1), p. 1 - 3 3 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Morphine tolerance is dependent upon PKC activation at the level of the mu-opioid receptor

Bailey, CP., Dalton, GD., Smith, FL., Dewey, WL. & Henderson, G., 2005, In : Society for Neuroscience Abstracts. 31, p. 374.2

Research output: Contribution to journalArticle (Academic Journal)