Professor Graham L Collingridge

B.Sc.(Bristol), Ph.D.(Lond.), F.R.S.

  • BS1 3NY

1992 …2020

Research output per year

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Personal profile

Research interests

The laboratory is interested in synaptic mechanisms and, in particular, synaptic plasticity in the mammalian central nervous system. Synaptic plasticity is the process by which synapses alter their efficiency and this property is used by the nervous system to store information. Synaptic plasticity is therefore a fundamental property of the brain involved in the development of the nervous system, learning & memory and other cognitive processes. Dysfunction of synaptic plastic processes is believed to be involved in various psychiatric and neurological disorders, including epilepsy and ischaemic brain injury. By elucidating the mechanisms of synaptic plasticity at a molecular level we can begin to understand how we are able to learn and remember, and how these processes are altered in conditions such as Alzheimer's Disease, schizophrenia, Parkinson's disease, chronic stress, anxiety, depression and epilepsy.

We are particularly interested in the phenomena of long-term potentiation (LTP) and long-term depression (LTD), which are forms of synaptic plasticity exhibited by many different classes of synapse in the brain. Most of our work focuses on synaptic plasticity in the hippocampus, a brain area important for learning and memory. Within the hippocampus we work on two main synapses, the Schaffer collateral / commissural projection from CA3 to CA1 neurons and the mossy fibre projection from dentate granule cells to CA3 neurons. The main focus of the work we do is to investigate the underlying mechanisms of different forms of LTP and LTD at these synapses using a combination of electrophysiological and imaging techniques.

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Projects

Research Output

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

Wang, J. X., Irvine, M. W., Burnell, E. S., Sapkota, K., Thatcher, R. J., Li, M., Simorowski, N., Volianskis, A., Collingridge, G. L., Monaghan, D. T., Jane, D. E. & Furukawa, H., 22 Jan 2020, In : Nature Communications. 11, 1, 14 p., 423.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 1 Citation (Scopus)
    47 Downloads (Pure)

    Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation

    Park, P., Sanderson, T. M., Bortolotto, Z. A., Georgiou, J., Zhuo, M., Kaang, B. K. & Collingridge, G. L., 3 Apr 2019, In : Molecular Brain. 12, 1, 5 p., 30.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 2 Citations (Scopus)
    116 Downloads (Pure)

    Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

    Irvine, M. W., Fang, G., Sapkota, K., Burnell, E. S., Volianskis, A., Costa, B. M., Culley, G., Collingridge, G. L., Monaghan, D. T. & Jane, D. E., 15 Feb 2019, In : European Journal of Medicinal Chemistry. 164, p. 471-498 28 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 3 Citations (Scopus)
    75 Downloads (Pure)

    Supervised Work

    Characterization of dissociative anesthetics acting at the NMDA receptor site

    Author: Kang, H. H., 19 Mar 2019

    Supervisor: Lightman, S. (Supervisor) & Collingridge, G. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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    Functional study of Kainate receptors in the mossy fibre pathway in the hippocampus

    Author: Lee, Y., 28 Nov 2019

    Supervisor: Bortolotto, Z. (Supervisor) & Collingridge, G. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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