Dr H M H N Bandara

BDS (HONS), PhD (H.K.)

  • BS1 2LY

20092020

Research output per year

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Personal profile

Research interests

Microbial communal interactions in many natural ecosystems, are yet to be fully unravelled. Hence my major research interest has been to elucidate physical and chemical interactions of microbes in competitive polymicrobial environments (fungal-bacterial biofilm communities in particular) to understand in depth the physiology of microbial communal lifestyle, as well as to define novel molecular pathways that can be targeted for translational research in future. In particular, the work I have undertaken thus far aims to characterize the response of the human fungal pathogen Candida to various bacterial quorum sensing signals (QSMs) using an inter–kingdom, fungal-bacterial interaction model system. Findings from my core research, such as the quorum sensing interaction between microbes, can be strategically translated to improve eco-balance in favour of beneficial organisms in host-parasite tussles or in industrial settings. Such possibilities not only include combating diseases (e.g. development of therapeutic agents to resolve catheter borne infections, biofilm mediated infections such as oral candidiasis, cystic fibrosis and root infections in plants, introducing probiotics to maintain gut microbiome), but also introducing beneficial microorganisms or their by-products to harmful microbial biofilms in industrial settings and other ecosystems (e.g. those that clog pipe borne water in effluent systems), introducing beneficial microbes to naturally fertilize farm fields, generating biofuel via biodegradation, purifying water and preserving dairy products.

Education/Academic qualification

20172019

The University of Hong Kong

20072011

The University of Peradeniya

20012006

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Research Output

  • 30 Article (Academic Journal)
  • 3 Chapter in a book
  • 2 Review article (Academic Journal)
  • 1 Conference Contribution (Conference Proceeding)

A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms

Bandara, H. M. H. N., Hewavitharana, A. K., Shaw, P. N., Smyth, H. D. C. & Samaranayake, L. P., 30 Mar 2020, In : International Journal of Pharmaceutics. 578, 12 p., 119096.

Research output: Contribution to journalArticle (Academic Journal)

  • Fluconazole resistance in Candida albicans is induced by Pseudomonas aeruginosa quorum sensing

    Bandara, H. M. H. N., Wood, D. L. A., Vanwonterghem, I., Hugenholtz, P., Cheung, B. P. K. & Samaranayake, L. P., 8 May 2020, In : Scientific Reports. 10, 1, 17 p., 7769 (2020).

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 26 Downloads (Pure)

    Biodiversity of the human oral mycobiome in health and disease

    Bandara, H. M. H. N., Panduwawala, C. P. & Samaranayake, L. P., 1 Mar 2019, In : Oral Diseases. 25, 2, p. 363-371 9 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 6 Citations (Scopus)
    160 Downloads (Pure)

    Prizes

    Colgate best oral presentation award

    Bandara, H M H N (Recipient), 2010

    Prize: National/international honour

    Dr. J. B. Abeykoon prize for excellence in oral pathology

    Bandara, H M H N (Recipient), 2006

    Prize: Prizes, Medals, Awards and Grants

    Dr. Ranjan Abesinghe prize for the excellence in dental surgery

    Bandara, H M H N (Recipient), 2006

    Prize: Prizes, Medals, Awards and Grants

    Activities

    • 6 Membership of external research organisation

    British Society for Medical Mycology (External organisation)

    H M H N Bandara (Advisor)

    2020 → …

    Activity: Membership typesMembership of external research organisation

    International Association for Dental Research (IADR) (External organisation)

    H M H N Bandara (Member)

    20142017

    Activity: Membership typesMembership of external research organisation

    American Society for Microbiology (ASM) (External organisation)

    H M H N Bandara (Member)

    20132014

    Activity: Membership typesMembership of external research organisation