Dr Hannah Gill

Bsc (Hons), MB ChB, FRCA, PhD

  • BS8 1TD

20132020

Research output per year

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Personal profile

Research interests

I am interested in the effects of anaesthetic drugs, particularly inhalational anaesthetics, on developing brain. Millions of fetuses, neonates and young children are exposed to anaesthetic drugs for surgery every year and clinical evidence suggests there is a small risk of detriment to long-term neurodevelopment, increased with longer cumulative exposure and earlier exposure. 

Laboratory studies in immature rodents, pigs and non-human primates have shown an association between exposure to commonly used anaesthetic drugs and widespread increased apoptosis in the brain: this has also been associated with detrimental effects on neuro-behaviourial outcomes in rodents. Xenon, a noble gas, with anaesthetic properties has been shown to prevent apoptosis induced by isoflurane, a commonly used inhalational anaesthetic in immature rodent brain.

I am interested in studying the effects of mixtures of xenon and common inhalational anaesthetic in immature rodent models of anaesthesia and in human infants undergoing surgery, in particular, to establish methods to optimise translation between the two settings. 

 

External positions

Specialist Trainee Anaesthesia, Intensive Care and Pain, NHS

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Research Output

  • 11 Article (Academic Journal)
  • 1 Editorial (Academic Journal)

Airway management for dental clearance in a preschool child: A UK survey

Shrimpton, A. J. & Gill, H., 16 Apr 2020, (Accepted/In press) In : Paediatric Anaesthesia.

Research output: Contribution to journalArticle (Academic Journal)

  • Early childhood general anesthesia and neurodevelopmental outcomes in the ALSPAC birth cohort

    Walkden, G., Gill, H., Davies, N. M., Peters, A. E., Wright, I. & Pickering, A. E., 27 Jul 2020, (Accepted/In press) In : Anesthesiology.

    Research output: Contribution to journalArticle (Academic Journal)

  • Perioperative management of oral cleft repair: a retrospective chart review

    Shrimpton, A. J. & Gill, H., 10 Apr 2020, In : Pediatric Anesthesia.

    Research output: Contribution to journalArticle (Academic Journal)