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Research Output

  • 34 Article (Academic Journal)
  • 5 Conference Contribution (Conference Proceeding)
  • 2 Working paper and Preprints
2016

Torsades-de-Pointes Predisposing Risk Factors (TdPPRFs) in a cohort of patients maintained on high dose methadone – a clinical safety caseload analysis

Iosub, R., Hawkins, S., McCarville, C., Kennedy, H., Williams, K. & Watson, B., 12 May 2016, In : European Psychiatry. 33, Supplement, p. S301-S302 2 p.

Research output: Contribution to journalArticle (Academic Journal)

2015

Calcium-induced calcium release during action potential firing in developing inner hair cells

Iosub, R., Avitabile, D., Grant, L., Tsaneva-Atanasova, K. & Kennedy, H. J., 10 Mar 2015, In : Biophysical Journal. 108, 5, 6394.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)
2014

Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia

Hulse, R. P., Beazley-Long, N., Hua, J., Kennedy, H., Prager, J., Bevan, H., Qiu, Y., Fernandes, E. S., Gammons, M. V., Ballmer-Hofer, K., Gittenberger de Groot, A. C., Churchill, A. J., Harper, S. J., Brain, S. D., Bates, D. O. & Donaldson, L. F., Nov 2014, In : Neurobiology of Disease. 71, 1, p. 245-259 15 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)
2013

Comparison of nonlinear mammalian cochlear-partition models

Szalai, R., Ó Maoiléidigh, D., Kennedy, H. J., Cooper, N., Champneys, A. R. & Homer, M. E., Jan 2013, In : Journal of the Acoustical Society of America. 133, 1, p. 323-336 14 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

The resting transducer current drives spontaneous activity in prehearing mammalian cochlear inner hair cells.

Johnson, S., Kennedy, H. J., Holley, M., Fettiplace, R. & Marcotti, W., 2012, In : Journal of Neuroscience. 32, 31, p. 10479-10483 5 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)
2011

Nonlinear models of development, amplification and compression in the mammalian cochlea

Szalai, R., Tsaneva-Atanasova, KT., Homer, ME., Champneys, AR., Kennedy, HJ. & Cooper, NP., 11 Jan 2011.

Research output: Working paperWorking paper and Preprints

File
704 Downloads (Pure)

Nonlinear models of development, amplification and compression in the mammalian cochlea

Szalai, R., Tsaneva-Atanasova, KT., Homer, ME., Champneys, AR., Kennedy, HJ. & Cooper, NP., Nov 2011, In : Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 369, 1954, p. 4183 - 4204 22 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

On the origins of the compressive cochlear nonlinearity

Szalai, R., Champneys, AR., Homer, ME., O Maoileidigh, D., Kennedy, HJ. & Cooper, NP., Jun 2011.

Research output: Working paperWorking paper and Preprints

File
296 Downloads (Pure)
2006

Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms

Kennedy, HJ., Evans, MG., Crawford, AC. & Fettiplace, R., 8 Mar 2006, In : Journal of Neuroscience. 26 (10), p. 2757 - 2766 10 p.

Research output: Contribution to journalArticle (Academic Journal)

74 Citations (Scopus)
2005

Development of outward potassium currents in inner and outer hair cells from the embryonic mouse cochlea

Helyer, RJ., Kennedy, HJ., Davies, D., Holley, MC. & Kros, CJ., Jan 2005, In : Audiology and Neurotology. 10 (1), p. 22 - 34 13 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Force generation by mammalian hair bundles supports a role in cochlear amplification

Kennedy, HJ., Crawford, AC. & Fettiplace, R., 24 Feb 2005, In : Nature. 433 (7028), p. 880 - 883 4 p.

Research output: Contribution to journalArticle (Academic Journal)

228 Citations (Scopus)
2003

Fast adaptation of mechanoelectrical transducer channels in mammalian cochlear hair cells

Kennedy, HJ., Evans, MG., Crawford, AC. & Fettiplace, R., Aug 2003, In : Nature Neuroscience. 6 (8), p. 832 - 836 5 p.

Research output: Contribution to journalArticle (Academic Journal)

186 Citations (Scopus)
2002

E-cadherin and the differentiation of mammalian vestibular hair cells

Hackett, L., Davies, D., Helyer, RJ., Kennedy, HJ., Kros, C., Lawlor, P., Rivolta, MN. & Holley, MC., 2002, In : Experimental Cell Research. 278, p. 19 - 30

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Fast Ca2+ signals at mouse inner hair cell synapse: a role for Ca2+ induced Ca2+ release

Kennedy, H. J. & Meech, R. W., 15 Feb 2002, In : Journal of Physiology. 539, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Intracellular calcium regulation in inner hair cells from neonatal mice

Kennedy, HJ., Mar 2002, In : Cell Calcium. 31 (3), p. 127 - 136 10 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)
2001

FM-143 behaves as a permanent blocker of the Hair-cell's mechanotransducer channel

Gale, JE., Marcotti, W., Kennedy, HJ., Kros, CJ. & Richardson, GP., 2001, In : Journal of Neuroscience. 21 (18), p. 7013 - 7025

Research output: Contribution to journalArticle (Academic Journal)

Intracellular calcium regulation in inner hair cells from neonatal CD-1 mice

Kennedy, HJ. & Meech, RW., 2001, The 24th Annual ARO MidWinter.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

The function of E-cadherin in the diffentiation of mammalian vestibular hair cells in vitro

Hackett, L., Lawlor, P., Helyer, RJ., Rivolta, M., Kennedy, HJ., Davies, D. & Holley, MC., 2001, Journal of the Association for Research in Otolaryngology Supplement, 24th Annual Midwinter Meeting. p. 585 - 585 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

2000

Sodium independent regulation of intracellular calcium in inner hair cells from neonatal CD-1 mice

Kennedy, HJ., Kros, CJ. & Meech, RW., 2000, In : Journal of Physiology.

Research output: Contribution to journalArticle (Academic Journal)

1999

Dynamic imaging of [ATP] in subcellular compartments with recombinant luciferases

Rutter, GA., Kennedy, HJ., Pouli, A., Jouaville, LS. & Rizzuto, R., 1999, In : Journal of Bioluminescence and Chemiluminescence. p. 236 - 239

Research output: Contribution to journalArticle (Academic Journal)

Glucose enhances insulin promoter activity in MIN6 beta-cells independently of chnages in intracellular calcium concentration and insuling secretion

Kennedy, HJ., Rafiq, I., Pouli, A. & Rutter, GA., 1999, In : Biochemical Journal. 342, p. 275 - 280

Research output: Contribution to journalArticle (Academic Journal)

Glucose enhances insulin promoter activity in MIN6 β-cells independently of changes in intracellular Ca2+ concentration and insulin secretion

Kennedy, HJ., Rafiq, I., Pouli, A. & Rutter, GA., 1999, In : Biochemical Journal. 342, p. 275 - 280

Research output: Contribution to journalArticle (Academic Journal)

Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria

Kennedy, HJ., Violett, B., Rafiq, I., Kahn, A. & Rutter, GA., 1999, In : Journal of Biological Chemistry. 274, p. 13281 - 13291

Research output: Contribution to journalArticle (Academic Journal)

Glucose generates sub-plasma membrane ATP microdomains in single islet β-cells

Kennedy, HJ., Pouli, A., Ainscow, EK., Jouaville, LS., Rizzuto, R. & Rutter, GA., 1999, In : Journal of Biological Chemistry. 274, p. 13281 - 13291

Research output: Contribution to journalArticle (Academic Journal)

248 Citations (Scopus)
1998

Dynamic imaging of subplasma membrane [ATP] in Β-cells with a SNAP-25.firefly luciferase chimaera

Rutter, GA., Kennedy, HJ. & Pouli, A., 1998, In : Diabetologia. 41, A13-A13.

Research output: Contribution to journalArticle (Academic Journal)

Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 β-cells

Rafiq, I., Kennedy, HJ. & Rutter, GA., 1998, In : Journal of Biological Chemistry. 273, p. 23241 - 23247

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)

Imaging glucose-induced increases in ATP in single living islet β-cells

Kennedy, HJ., Pouli, A., Jouaville, LS., Rizzuto, R. & Rutter, GA., 1998, In : Diabetic Medicine. 15(4), S13-S14.

Research output: Contribution to journalArticle (Academic Journal)

Insulin targeting to the regulated secretory pathway after fusion with green fluorescent protein and firefly luciferase

Pouli, A., Kennedy, HJ., Schofield, GS. & Rutter, GA., 1998, In : Biochemical Journal. 331, p. 669 - 675

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)

Quantative real-time imaging of gene expression in single cells using multiple luciferase reporters

Rutter, GA., Kennedy, HJ., Wood, C., White, MRH. & Tavaré, JM., 1998, In : Chemistry and Biology. 5, R285-R290.

Research output: Contribution to journalArticle (Academic Journal)

Regulation of insulin and c-fos promoter activity in single islet β-cells

Kennedy, HJ., Rafiq, I., Bäding, H. & Rutter, GA., 1998, In : Diabetic Medicine. 15(4), S22-S23.

Research output: Contribution to journalArticle (Academic Journal)

Regulation of insulin gene by insulin promoter factor 1 (IPF-1)

Rafiq, I., Kennedy, HJ. & Rutter, GA., 1998, In : Diabetic Medicine. 15(4), S21-S21.

Research output: Contribution to journalArticle (Academic Journal)

1997

Upstream stimulatory factor-2 (USF2) activity is required for glucose stimulation of L-pyruvate kinase promoter activity in single living islet β cells

Kennedy, HJ., Viollet, B., Rafiq, I., Kahn, A. & Rutter, GA., 1997, In : Journal of Biological Chemistry. 272, p. 20636 - 20640

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)
1996

Effects of injecting calcium buffer solutions on [Ca2+]i in voltage-clamped snail neurons

Kennedy, HJ. & Thomas, RC., 1996, In : Biophysical Journal. 70, p. 2120 - 2130

Research output: Contribution to journalArticle (Academic Journal)

1994

The effects of injecting calcium buffer solutions on intracellular calcium in snail neurones in isolated ganglia

Thomas, RC. & Kennedy, HJ., 1994, Unknown. Vol. 479. p. 11 - 11 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

1993

Calcium-hydrogen exchange by the plasma membrane Ca-ATPase of voltage-clamped snail neurons

Schwiening, CJ., Kennedy, HJ. & Thomas, RC., 1993, In : Proceedings of the Royal Society B: Biological Sciences. 253, p. 285 - 289 4 p.

Research output: Contribution to journalArticle (Academic Journal)

96 Citations (Scopus)

Proton transport by the plasma membrane Ca2+-ATPase of voltage-clamped snail neurones in isolated ganglia

Schwiening, CJ., Kennedy, HJ. & Thomas, RC., 1993, Unknown. Vol. 473. p. 39 - 39 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

1 Citation (Scopus)

The effect of vanadate on intracellular calcium in neurones in isolated snail ganglia

Kennedy, HJ. & Thomas, RC., 1993, Unknown. Vol. 467. p. 169 - 169 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

1992

Simultaneous Fura-2 and ion-sensitive microelectrode measurement of free calcium ion changes in voltage-clamped Helix aspersa neurones

Thomas, RC. & Kennedy, HJ., 1992, In : Journal of Physiology. 446, p. 134 - 134 1 p.

Research output: Contribution to journalArticle (Academic Journal)