Dr Helen L Winton

B.Sc.(Wales), PhD, Bristol

  • BS8 2PS

19982019

Research output per year

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Personal profile

Research interests

I currently work as the Clinical Trial Manager for a NIHR HTA study called 'Prepare for Kidney Care'.  The study is a randomised controlled trial comparing two care pathways: a) preparing for renal dialysis and b) preparing for responsive management (an optimised form of conservative care) in frail, older patients with multiple health problems and advanced chronic kidney disease. This is a national, multi-centre trial recruiting patients from secondary care renal units, with the intervention being delivered predominantly in the community. The trial is open to recruitment and currently has 20 participating sites from England, Scotland and Wales, with additional sites being opened.

 

Previous Trial Management Experience:

  • UPSTREAM Trial (ISRCTN561642740): Urodynamics for Prostate Surgery Trial: Randomised Evaluation Assessment of Assessment Methods. Questions being addressed are: Is a care pathway not including invasive urodynamics no worse for men in terms of symptom outcome than one in which it is included? Responsible for managing 26 clinical sites, hitting and exceeding the overall recruitment target and collecting follow-up to 18 months.
  • Clinical Trial Manager of a spin-out company from Bristol University called Micrima.  Micrima are a medical device company interested in the clinical applications of microwave imaging for breast cancer detection.
  • Clinical Study Co-ordinator for a large prospective, multi-centre NIHR CRN Portfolio Study 9871 (ISRCTN25094892), investigating the role of HLA Class II mismatching in High Risk Corneal Transplantation (CTFS II). Having recruited over 1125 corneal transplant recipients from 31 sites around the UK, with 6 month and annual follow-up up to five years, the CTFS II study investigated tissue typed matching with risk of transplant rejection. In addition, I set up a corneal transplant recipient DNA bank and investigated the association of genetic variants in the setting of ocular inflammation and transplant rejection, which led to the award of PhD ' Inflammation related genetic variants in high risk corneal transplantation'.

Other research interests have included collaboration with a French Biotechnology company and University College London, where I was part of a team investigating and delivering in vitro and transplantation studies. This research was pivotal in aiding the first in human transplantion of stem cells for the treatment of Age-Related Macular Degeneration.

Research Interests: Multi-centre clinical trial management, nephrology, urology, breast cancer, corneal transplantation, genetics and immunology.

 

 

External positions

Clinical Trial manager, Micrima Limited, The Engine Shed, Station Approach, Bristol BS1 6QH

Nov 2015May 2016

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Research Output

  • 19 Article (Academic Journal)
  • 2 Conference Poster
  • 1 Conference Abstract
Open Access
File
  • 1 Citation (Scopus)
    194 Downloads (Pure)
    Open Access
    File
  • 2 Citations (Scopus)
    146 Downloads (Pure)
    Open Access
    File
  • 4 Citations (Scopus)
    266 Downloads (Pure)