Our tissues are frequently exposed to a wide-range of endogenous and exogenous insults that could threaten the integrity of their genome, proteome and metabolome. This occurs when tissues are injured, as inflammatory cells generate toxic products, and also in otherwise healthy tissues as similar products are generated as a normal byproduct of cellular metabolism and physiology. How do our tissues withstand these insults? In our lab, we explore the diverse, powerful defense strategies used by developing and repairing tissues to make them resilient to this damage.

We use an exciting interdisciplinary approach that combines in vivo imaging and genetics in Drosophila with human genetic epidemiology, to explore tissue resilience mechanisms in development and wound repair.

For more information see our lab website.