Professor Ian R Collinson

B.Sc.(Warw.), Ph.D.(Cantab.)

  • BS8 1TD

20012020

Research output per year

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Research Output

  • 41 Article (Academic Journal)
  • 3 Chapter in a book
  • 1 Special issue (Academic Journal)
  • 1 Review article (Academic Journal)
2019

A high-resolution luminescent assay for rapid and continuous monitoring of protein translocation across biological membranes

De Castro Pereira, G., Allen, W., Watkins, D., Buddrus, L., Noone, D., Liu, X., Richardson, A., Collinson, I. & Chacinska, A., 5 Apr 2019, In : Journal of Molecular Biology. 431, 8, p. 1689-1699 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
159 Downloads (Pure)

ATP-induced asymmetric pre-protein folding as a driver of protein translocation through the Sec machinery

Corey, R., Ahdash, Z., Shah, A., Pyle, E., Allen, W., Fessl, T., Lovett, J. E., Politis, A. & Collinson, I., 2 Jan 2019, In : eLife. 8, 55 p., e41803.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
163 Downloads (Pure)

Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation

Pereira, F., Rettel, M., Stein, F., Savitski, M. M., Collinson, I. & Römisch, K., 25 Jan 2019, In : PLoS ONE. 14, 1, 19 p., e0211180.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
166 Downloads (Pure)

HDX-MS reveals nucleotide-dependent, anti-correlated opening and closure of SecA and SecY channels of the bacterial translocon

Ahdash, Z., Pyle, E., Allen, W., Corey, R., Collinson, I. & Politis, A., 10 Jul 2019, In : eLife. 8, 12 p., e47402.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
90 Downloads (Pure)

Post-Translational Protein Transport by the Sec Complex

Allen, W., Collinson, I. & Römisch, K., 1 Jun 2019, In : Trends in Biochemical Sciences. 44, 6, p. 481-483 3 p.

Research output: Contribution to journalSpecial issue (Academic Journal)

Open Access
File
1 Citation (Scopus)
35 Downloads (Pure)

Structure and Dynamics of the Central Lipid Pool and Proteins of the Bacterial Holo-Translocon

Martin, R., Larsen, A. H., Corey, R. A., Midtgaard, S. R., Frielinghaus, H., Schaffitzel, C., Arleth, L. & Collinson, I., 21 May 2019, In : Biophysical Journal. 116, 10, p. 1931-1940 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
141 Downloads (Pure)

The dynamic ATP-driven mechanism of bacterial protein translocation and the critical role of phospholipids

Collinson, I., 19 Jun 2019, In : Frontiers in Microbiology. 10, JUN, 7 p., 1217.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
133 Downloads (Pure)
2018

Dynamic action of the Sec machinery during initiation, protein translocation and termination

Fessl, T., Watkins, D. W., Oatley, P., Allen, W., Corey, R., Horne, J., Baldwin, S. A., Radford, S. E., Collinson, I. & Tuma, R., 7 Jun 2018, In : eLife. 7, 68 p., e35112.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
19 Citations (Scopus)
210 Downloads (Pure)

Specific cardiolipin–SecY interactions are required for proton-motive force stimulation of protein secretion

Corey, R. A., Pyle, E., Allen, W. J., Watkins, D. W., Casiraghi, M., Miroux, B., Arechaga, I., Politis, A. & Collinson, I., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. 7967-7972 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
18 Citations (Scopus)
228 Downloads (Pure)
2017

Multiprotein complex production in E. coli: the SecYEG-SecDFYajC-YidC Holotranslocon

Berger, I., Jiang, Q., Schulze, R., Collinson, I. & Schaffitzel, C., 2017, Heterologous Gene Expression in E.coli: Methods and Protocols. Burgess-Brown, N. A. (ed.). Springer, p. 279-290 12 p. (Methods in Molecular Biology; vol. 1586).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
240 Downloads (Pure)

SecA – a new twist in the tail

Collinson, I., 1 Jan 2017, In : Journal of Bacteriology. 199, 2, 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
228 Downloads (Pure)

The accessory Sec system (SecY2A2) in Streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation

Jayaweera Bandara, M., Skehel, J. M., Kadioglu, A., Collinson, I., Nobbs, A. H., Blocker, A. J. & Jenkinson, H. F., Aug 2017, In : Microbes and Infection. 19, p. 402-412 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
388 Downloads (Pure)
2016

ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts

Nie, Y., Chaillet, M., Becke, C., Haffke, M., Pelosse, M., Fitzgerald, D., Collinson, I., Schaffitzel, C. & Berger, I., 11 May 2016, Advanced Technologies for Protein Complex Production and Characterization. Vega, M. C. (ed.). Springer International Publishing AG, p. 27-42 16 p. (Advances in Experimental Medicine and Biology; vol. 896).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
7 Citations (Scopus)
359 Downloads (Pure)

A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion

Botte, M., Zaccai, N. R., Nijeholt, J. L. À., Martin, R., Knoops, K., Papai, G., Zou, J., Deniaud, A., Karuppasamy, M., Jiang, Q., Roy, A. S., Schulten, K., Schultz, P., Rappsilber, J., Zaccai, G., Berger, I., Collinson, I. & Schaffitzel, C., 7 Dec 2016, In : Scientific Reports. 6, 13 p., 38399.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
16 Citations (Scopus)
234 Downloads (Pure)

Composition and activity of the non-canonical Gram-positive SecY2 complex

Jayaweera Bandara, M., Corey, R., Martin, R., Blocker, A., Jenkinson, H. & Collinson, I., 7 Oct 2016, In : Journal of Biological Chemistry. 291, 41, p. 21474-21484 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
1227 Downloads (Pure)

Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG-SecDF-YajC-YidC

Komar, J., Alvira-de-Celis, S., Schulze, R., Martin, R., Nijeholtb, J. A. L. A., Lee, S., Dafforn, T., Deckers-Hebestreit, G., Berger, I., Schaffitzel, C. & Collinson, I., Oct 2016, In : Biochemical Journal. 473, p. 3341-3354 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
24 Citations (Scopus)
379 Downloads (Pure)

Protein translocation: what’s the problem?

Corey, R. A., Allen, W. J. & Collinson, I. R., Jun 2016, In : Biochemical Society Transactions. 44, 3, p. 753-759 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
1162 Downloads (Pure)

Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation

Allen, W., Corey, R., Oatley, P., Sessions, R., Baldwin, S. A., Radford, S. E., Tuma, R. & Collinson, I., 14 Jun 2016, In : eLife. 5, 23 p., e15598.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
48 Citations (Scopus)
1260 Downloads (Pure)

Unlocking the bacterial SecY translocon

Corey, R. A., Allen, W. J., Komar, J., Masiulis, S., Menzies, S., Robson, A. & Collinson, I. R., 10 Mar 2016, In : Structure. 24, p. 1-10 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
1259 Downloads (Pure)
2015

ACEMBLing a Multiprotein Transmembrane Complex: The Functional SecYEG-SecDF-YajC-YidC Holotranslocon Protein Secretase/Insertase.

Komar, J., Botte, M., Collinson, I. R., Schaffitzel, C. & Berger, I., 20 Mar 2015, In : Methods in Enzymology. 556, p. 23-49

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Advances and challenges of membrane-protein complex production

Zorman, S., Botte, M., Jiang, Q., Collinson, I. & Schaffitzel, C., Jun 2015, In : Current Opinion in Structural Biology. 32, p. 123-30 8 p.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Channel crossing: how are proteins shipped across the bacterial plasma membrane?

Collinson, I., Corey, R. A. & Allen, W. J., 5 Oct 2015, In : Philosophical Transactions B: Biological Sciences. 370, 1679

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)
2014

Membrane protein insertion and proton-motive-force-dependent secretion through the bacterial holo-translocon SecYEG-SecDF-YajC-YidC

Schulze, R. J., Komar, J., Botte, M., Allen, W. J., Whitehouse, S., Gold, V. A. M., Nijeholtb, J. A. L. A., Huard, K., Berger, I., Schaffitzel, C. & Collinson, I., 1 Apr 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 13, p. 4844-4849 6 p.

Research output: Contribution to journalArticle (Academic Journal)

68 Citations (Scopus)
2013

The dynamic action of SecA during the initiation of protein translocation

Gold, V. A. M., Robson, A., Whitehouse, S. & Collinson, I. R., 2013, In : Biochemical Journal. 449, 3, p. 695-705

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Using 2D crystals to analyze the structure of membrane proteins

Collinson, I., Vonck, J. & Hizlan, D., 2013, In : Methods in Molecular Biology. 1033, p. 47-65 19 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
2012

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex

Whitehouse, S., Gold, V. A. M., Robson, A., Allen, W. J., Sessions, R. B. & Collinson, I., 10 Dec 2012, In : Journal of Cell Biology. 199, 6, p. 919-929 11 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Structure of the SecY complex unlocked by a preprotein mimic

Hizlan, D., Robson, A., Whitehouse, S., Gold, V. A. M., Vornck, J., Mills, D., Kühlbrandt, W. & Collinson, I., Jan 2012, In : Cell Reports. 1, 1, p. 21 - 28 8 p.

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)
2011

Dynamic nuclear polarization-enhanced solid-state NMR of a 13C-labeled signal peptide bound to lipid-reconstituted Sec translocon

Reggie, L., Lopez, JJ., Collinson, I., Glaubitz, C. & Lorch, M., 30 Nov 2011, In : Journal of the American Chemical Society. 133, 47, p. 19084 - 19086 3 p.

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)

The oligomeric state and arrangement of the active bacterial translocon

Deville, K., Gold, VAM., Robson, A., Whitehouse, S., Sessions, RB., Baldwin, SA., Radford, SE. & Collinson, I., Dec 2011, In : Journal of Biological Chemistry. 286 (6), p. 4659 - 4669 11 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)
2010

The action of cardiolipin on the bacterial translocon

Gold, V. A. M., Robson, A., Bao, H., Romantsov, T., Duong, F. & Collinson, I., Jun 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107 , 22, p. 10044 - 10049 6 p.

Research output: Contribution to journalArticle (Academic Journal)

94 Citations (Scopus)
2009

Automated unrestricted multigene recombineering for multiprotein complex production

Bieniossek, C., Nie, Y., Frey, D., Olieric, N., Schaffitzel, C., Collinson, I., Romier, C., Berger, P., Richmond, T. J., Steinmetz, M. O. & Berger, I., Jun 2009, In : Nature Methods. 6, 6, p. 447 - 450 4 p.

Research output: Contribution to journalArticle (Academic Journal)

71 Citations (Scopus)

Energy transduction in protein transport and the ATP hydrolytic cycle of SecA

Robson, A., Gold, V. A. M., Hodson, S., Clarke, A. R. & Collinson, I., Mar 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106 , 13, p. 5111 - 5116 6 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Synthetic peptides identify a second periplasmic site for the plug of the SecYEG protein translocation complex

Robson, A., Carr, B., Sessions, RB. & Collinson, I., Jan 2009, In : FEBS Letters. 583 (1), p. 207 - 212 6 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

YidC and Oxa1 form dimeric insertion pores on the translating ribosome

Kohler, R., Boehringer, D., Greber, B., Bingel-Erlenmeyer, R., Collinson, I., Schaffitzel, C. & Ban, N., 15 May 2009, In : Molecular Cell. 34, 3, p. 344 - 353 10 p.

Research output: Contribution to journalArticle (Academic Journal)

91 Citations (Scopus)
2008

Projection structure of yidC: a conserved mediator of membrane protein assembly

Lotz, M., Haase, W., Kühlbrandt, W. & Collinson, I., Jan 2008, In : Journal of Molecular Biology. 375 (4), p. 901 - 907 7 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)
2007

A large conformational change couples the ATP binding site of SecA to the SecY protein channel

Robson, A., Booth, AEG., Gold, VAM., Clarke, AR. & Collinson, I., Dec 2007, In : Journal of Molecular Biology. 374 (4), p. 965 - 976 12 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Allosteric regulation of SecA. Magnesium-mediated control of conformation and activity

Gold, VAM., Robson, A., Clarke, AR. & Collinson, I., Jun 2007, In : Journal of Biological Chemistry. 282 (24), p. 17424 - 17432 9 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Structure and function of the bacterial Sec translocon (Review)

Gold, VAM., Duong, F. & Collinson, I., Jun 2007, In : Molecular Membrane Biology. 24 (5-6), p. 387 - 394 8 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)
2006

The Structure of the Sec complex and the problem of protein translocation

Robson, A. & Collinson, I., Nov 2006, In : EMBO Reports. 7 (11), p. 1099 - 1103 5 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

The Structure of the SecY protein translocation channel

van den Berg, B. & Collinson, I., 2006, Structural Biology of Membrane Proteins. Grisshammer, R. & Buchanan, SK. (eds.). The Royal Scociety of Chemistry, p. 252 - 266 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

3 Citations (Scopus)
2005

Atomic model of the E. coli membrane-bound protein translocation complex SecYEG

Bostina, M., Mohsin, B., Kühlbrandt, W. & Collinson, I., Oct 2005, In : Journal of Molecular Biology. 352 (5), p. 1035 - 1043 9 p.

Research output: Contribution to journalArticle (Academic Journal)

38 Citations (Scopus)

The Structure of the bacterial protein translocation complex SecYEG

Collinson, I., 2005, In : Biochemical Society Transactions. 33(6), p. 1225 - 1230 6 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)
2004

The bacterial protein-translocation complex: SecYEG dimers associate with one or two SecA molecules

Tziatzios, C., Schubert, D., Lotz, M., Gundogan, D., Betz, H., Schägger, H., Haase, W., Duong, F. & Collinson, I., 2004, In : Journal of Molecular Biology. 340, p. 513 - 524 12 p.

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)

X-ray structure of a protein-conducting channel

van den Berg, B., Clemens Jr, WM., Collinson, I., Modis, Y., Hartmann, E., Harrison, SC. & Rapoport, TA., 1 Jan 2004, In : Nature. 427 (6969), p. 36 - 44 9 p.

Research output: Contribution to journalArticle (Academic Journal)

882 Citations (Scopus)
2002

Three-dimensional structure of the bacterial protein-translocation complex SecYEG

Breyton, C., Haase, W., Rapoport, TA., Kühlbrandt, W. & Collinson, I., 8 Aug 2002, In : Nature. 418 (6898), p. 662 - 665 4 p.

Research output: Contribution to journalArticle (Academic Journal)

206 Citations (Scopus)
2001

Projection structure and oligomeric properties of a bacterial core protein translocase

Collinson, I., Breyton, C., Duong, F., Tziatzios, C., Schubert, D., Or, E., Rapoport, T. & Kühlbrandt, W., May 2001, In : EMBO Journal. 20 (10), p. 2462 - 2471 10 p.

Research output: Contribution to journalArticle (Academic Journal)

102 Citations (Scopus)