Projects per year
Personal profile
Research interests
How does platelet stimulation by a variety of agonists lead to activation and platelet aggregation? We are interested in elucidating the signalling pathways that are involved in platelet activation, in particular those that may play a role in platelet hyperactivity in conditions such as obesity and diabetes. Platelets are able to respond to a wide range of agonists and when activated at the site of injury they rapidly aggregate to form a platelet haemostatic plug. Increased or inappropriate platelet activation, however, will lead to thrombosis and vascular complications. Risk factors such as obesity and some genetic factors lead to a resistance to insulin, which is the major underlying cause of type II, adult-onset diabetes, the most common type of diabetes. Type II diabetes is associated with an increased risk of cardiovascular complications, which is the main cause of morbidity and mortality in these patients. There is substantial evidence for platelet hyperactivity in patients with diabetes, which is thought to play a contributory role in diabetic heart disease. Although, the pathogenesis of diabetic cardiovascular disease is not yet fully understood, it is likely to involve the clustering of certain risk factors, often called the insulin resistance syndrome, which is associated with type II diabetes. In our lab, we are interested in investigating the contribution of these risk factors to making platelets hyper responsive.
Fingerprint Dive into the research topics where Ingeborg Hers is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 4 Similar Profiles
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Investigating the role of the STE kinase STK24/MST3 in platelet function and thrombosis
Hers, I., Moore, S. F. & Garcia, A.
22/05/18 → 23/07/19
Project: Research
Evaluation of the role of ARAP1 in platelet function and thrombosis
1/04/18 → 30/09/19
Project: Research
Research Output
Carbonic Anhydrase Inhibitors Suppress Platelet Procoagulant Responses and In Vivo Thrombosis
Agbani, E. O., Zhao, X., Williams, C. M., Aungraheeta, R., Hers, I., Swenson, E. R. & Poole, A. W., 1 Jan 2020, In : Platelets. 7 p.Research output: Contribution to journal › Article (Academic Journal)
Identification of PtdIns(3,4)P2 effectors in human platelets using quantitative proteomics
Durrant, T. N., Moore, S. F., Bayliss, A. L., Jiang, Y., Aitken, E. W., Wilson, M. C., Heesom, K. J. & Hers, I., 1 Feb 2020, In : Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865, 2, 12 p., 158575.Research output: Contribution to journal › Article (Academic Journal)
File
Redundant role of ASK1-mediated p38MAPK activation in human platelet function
Sledz, K. M., Moore, S. F., Vijayaragavan, V., Mallah, S., Goudswaard, L. J., Williams, C. M., Hunter, R. W. & Hers, I., 1 Apr 2020, In : Cellular Signalling. 68, 11 p., 109528.Research output: Contribution to journal › Article (Academic Journal)
Supervised Work
Identification and Elucidation of Novel Platelet Primers
Author: Liu, H., 23 Jan 2019Supervisor: Hers, I. (Supervisor) & Poole, A. (Supervisor)
Student thesis: Master's Thesis › Master of Science (MSc)
File
The Effect of Hyperglycaemia and Thrombopoietin on Platelet Function
Author: Halliwell, S., 7 May 2019Supervisor: Hers, I. (Supervisor) & Poole, A. (Supervisor)
Student thesis: Master's Thesis › Master of Science (MSc)
File
Using Drosophila to model schizophrenia symptoms
Author: Hidalgo Sotelo, S. I., 12 May 2020Supervisor: Hodge, J. (Supervisor) & Hers, I. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)