Professor Ingeborg Hers

M.Sc.(Amst.), Ph.D.(Utrecht)

  • BS8 1TD

19992020

Research output per year

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Research Output

  • 40 Article (Academic Journal)
  • 1 Chapter in a book
  • 1 Letter (Academic Journal)
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Article (Academic Journal)
2020

Carbonic Anhydrase Inhibitors Suppress Platelet Procoagulant Responses and In Vivo Thrombosis

Agbani, E. O., Zhao, X., Williams, C. M., Aungraheeta, R., Hers, I., Swenson, E. R. & Poole, A. W., 1 Jan 2020, In : Platelets. 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Identification of PtdIns(3,4)P2 effectors in human platelets using quantitative proteomics

Durrant, T. N., Moore, S. F., Bayliss, A. L., Jiang, Y., Aitken, E. W., Wilson, M. C., Heesom, K. J. & Hers, I., 1 Feb 2020, In : Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1865, 2, 12 p., 158575.

Research output: Contribution to journalArticle (Academic Journal)

File
166 Downloads (Pure)

Redundant role of ASK1-mediated p38MAPK activation in human platelet function

Sledz, K. M., Moore, S. F., Vijayaragavan, V., Mallah, S., Goudswaard, L. J., Williams, C. M., Hunter, R. W. & Hers, I., 1 Apr 2020, In : Cellular Signalling. 68, 11 p., 109528.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2

Jing, C., Mallah, S., Kriemen, E., Bennett, S. H., Fasano, V., Lennox, A. J. J., Hers, I. & Aggarwal, V. K., 24 Jun 2020, In : ACS Central Science. 6, 6, p. 995–1000

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
26 Downloads (Pure)
2019

A negative feedback loop regulates integrin inactivation and promotes neutrophil recruitment to inflammatory sites

McCormick, B., Craig, H. E., Chu, J. Y., Carlin, L. M., Canel, M., Wollweber, F., Toivakka, M., Michael, M., Astier, A. L., Norton, L., Lilja, J., Felton, J. M., Sasaki, T., Ivaska, J., Hers, I., Dransfield, I., Rossi, A. G. & Vermeren, S., 19 Aug 2019, In : Journal of Immunology. 203, 9, 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
124 Downloads (Pure)

Critical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet function

Moore, S., Smith, N. R., Blair, T. A., Durrant, T. N. & Hers, I., 6 Feb 2019, In : Scientific Reports. 9, 13 p., 1468.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
200 Downloads (Pure)
2018

Aquaporin-1 Regulates Platelet Procoagulant Membrane Dynamics and In Vivo Thrombosis

Agbani, E., Williams, C., Li, Y., van den Bosch, M., Moore, S., Mauroux, A., Hodgson, L., Verkman, A. S., Hers, I. & Poole, A., 17 May 2018, In : JCI Insight. 3, 10, 16 p., e99062.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
273 Downloads (Pure)

Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation

Blair, T. A., Moore, S. F., Walsh, T. G., Hutchinson, J. L., Durrant, T. N., Anderson, K. E., Poole, A. W. & Hers, I., Oct 2018, In : Cellular Signalling. 50, p. 111-120 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
202 Downloads (Pure)
2017

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVIdriven platelet function

Durrant, T., Hutchinson, L., Heesom, K., Anderson, K., Stephens, L., Hawkins, P., Marshall, A., Moore, S. & Hers, I., 13 Jun 2017, In : Blood Advances. 1, 14, p. 918-932 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
328 Downloads (Pure)
Open Access
File
15 Citations (Scopus)
234 Downloads (Pure)

Temporal contribution of the platelet body and balloon to thrombin generation

Agbani, E., Hers, I. & Poole, A., 13 Jul 2017, In : Haematologica.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
263 Downloads (Pure)

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3)-binder Rasa3 Regulates Phosphoinositide 3-kinase (PI 3-kinase)-dependent Integrin αIIbβ3 Outside-in Signaling

Battram, A., Durrant, T., Agbani, E., Heesom, K., Paul, D. S., Piatt, R., Poole, A., Cullen, P., Bergmeier, W., Moore, S. & Hers, I., 3 Feb 2017, In : Journal of Biological Chemistry. 292, 5, p. 1691-1704 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
256 Downloads (Pure)
2016

Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets

Williams, C., Savage, J., Harper, M., Moore, S., Hers, I. & Poole, A., Jun 2016, In : Platelets. p. 286-94

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)
2015

Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal

Chen, M. Z., Hudson, C. A., Vincent, E. E., De Berker, D. A. R., May, M. T., Hers, I., Dayan, C. M., Andrews, R. C. & Tavare, J. M., 13 Apr 2015, In : PLoS ONE. 10, 4, e0120084.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Circulating primers enhance platelet function and induce resistance to antiplatelet therapy.

Moore, S., Hers, I. & Blair, T., Aug 2015, In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Coordinated membrane ballooning and procoagulant-spreading in human platelets

Agbani, E., Van den Bosch, M., Brown, E., Williams, C., Mattheij, N., Cosemans, J. M. E. M., Collins, P., Heemskerk, J. W. M., Hers, I. & Poole, A., 13 Oct 2015, In : Circulation. 132, 15, p. 1414-1424 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
58 Citations (Scopus)
433 Downloads (Pure)

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling

Moore, S. F., Williams, C. M., Brown, E., Blair, T. A., Harper, M. T., Coward, R. J., Poole, A. W. & Hers, I., 22 Apr 2015, In : Cardiovascular Research.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4-deficient platelets

Harper, M. T., van den Bosch, M. T., Hers, I. & Poole, A. W., 7 May 2015, In : Blood. 125, 19, p. 3034-6 3 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)
2014

Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6

van den Bosch, M. T. J., Poole, A. W. & Hers, I., May 2014, In : Journal of Thrombosis and Haemostasis. 12, 5, p. 726-35 10 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Is JAK2V617F finally off the hook?

Hers, I. & Poole, A. W., 14 Aug 2014, In : Blood. 124, 7, p. 992-3 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming

Blair, T. A., Moore, S. F., Williams, C. M., Poole, A. W., Vanhaesebroeck, B. & Hers, I., Aug 2014, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 8, p. 1681-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets

Moore, S. F., Hunter, R. W. & Hers, I., May 2014, In : Journal of Thrombosis and Haemostasis. 12, 5, p. 748-60 13 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)
2013

Absence of platelet phenotype in mice lacking the motor protein myosin Va

Harper, M. T., van den Bosch, M. T. J., Hers, I. & Poole, A. W., 2013, In : PLoS ONE. 8, 1, p. e53239

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt Promotes Thrombin-mediated Integrin alpha(IIb)beta(3) Activation and Granule Secretion in Platelets

Moore, S. F., van den Bosch, M. T. J., Hunter, R. W., Sakamoto, K., Poole, A. W. & Hers, I., 8 Feb 2013, In : Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.

Research output: Contribution to journalArticle (Academic Journal)

83 Citations (Scopus)

Dysfunction of the PI3 kinase/Rap1/integrin αIIbβ3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia

Moore, S. F., Hunter, R. W., Harper, M. T., Savage, J. S., Siddiq, S., Westbury, S. K., Poole, A. W., Mumford, A. D. & Hers, I., 2013, In : Blood. 121, 7, p. 1209-19 11 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Insulin-like growth factor-II is produced by, signals to, and is an important survival factor for the mature podocyte in man and mouse

Hale, L. J., Welsh, G. I., Perks, C. M., Hurcombe, J. A., Moore, S. F., Hers, I., Saleem, M., Mathieson, P. W., Murphy, AJ., Jeansson, M., Holly, J. M. P., Hardouin, SN. & Coward, R. J. M., May 2013, In : Journal of Pathology. 230, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Munc13-4 is critical for thrombosis through regulating release of ADP from platelets

Savage, J. S., Williams, C. M., Konopatskaya, O., Hers, I., Harper, M. T. & Poole, A. W., Apr 2013, In : Journal of Thrombosis and Haemostasis. 11, 4, p. 771-5 5 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor

Vincent, E. E., Elder, D. J. E., Curwen, J., Kilgour, E., Hers, I. & Tavaré, J. M., 2013, In : PLoS ONE. 8, 6, p. e66963

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)
2012

Bariatric surgery in morbidly-obese insulin resistant humans normalizes insulin signaling but not insulin-stimulated glucose disposal

Chen, MZ., Hudson, CA., Vincent, EE., de Berker, D., May, M., Hers, I., Dayan, CM., Andrews, RC. & Tavaré, JM., 2012, (In preparation) In : Diabetes.

Research output: Contribution to journalArticle (Academic Journal)

2011

Akt signalling in health and disease

Hers, I., Vincent, EE. & Tavaré, JM., Oct 2011, In : Cellular Signalling. 23 (10), p. 1515 - 1527 13 p.

Research output: Contribution to journalArticle (Academic Journal)

637 Citations (Scopus)

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

Moore, SF., Hunter, RW. & Hers, I., 15 Jul 2011, In : Journal of Biological Chemistry. 286, 28, p. 24553-24560

Research output: Contribution to journalArticle (Academic Journal)

64 Citations (Scopus)
2006

Identification of p122RhoGAP (deleted in liver cancer-1) serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells

Hers, I., Wherlock, M., Homma, Y., Yagisawa, H. & Tavaré, JM., Feb 2006, In : Journal of Biological Chemistry. 281 (8), p. 4762 - 4770 9 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Insulin, calcium and the control of mammalian metabolism: Regulation of small GTP-binding proteins by insulin

Welsh, GI., Hers, I., Wherlock, M. & Tavaré, JM., Apr 2006, In : Biochemical Society Transactions. 34 (2), p. 209 - 212 4 p.

Research output: Contribution to journalArticle (Academic Journal)

2005

Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes

Hers, I. & Tavaré, JM., Jun 2005, In : Biochemical Journal. 388 (2), p. 713 - 720 8 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Role of protein kinase B in insulin-regulated glucose uptake

Welsh, GI., Hers, I., Berwick, DC., Dell, G., Wherlock, M., Birkin, R., Leney, S. & Tavaré, JM., 2005, In : Biochemical Society Transactions. 33(2), p. 346 - 349 4 p.

Research output: Contribution to journalArticle (Academic Journal)

102 Citations (Scopus)
2004

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

Berwick, DC., Dell, GC., Welsh, GI., Heesom, KJ., Hers, I., Fletcher, LM., Cooke, FT. & Tavaré, JM., Dec 2004, In : Journal of Cell Science. 117 (25), p. 5985 - 5993 9 p.

Research output: Contribution to journalArticle (Academic Journal)

111 Citations (Scopus)
2002

Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes

Hers, I., Bell, CJ., Poole, AW., Jiang, D., Denton, RM., Schaefer, E. & Tavaré, JM., Dec 2002, In : Biochemical Journal. 368 (3), p. 875 - 884 10 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

Berwick, DC., Hers, I., Heesom, KJ., Moule, SK. & Tavaré, JM., Sep 2002, In : Journal of Biological Chemistry. 277 (37), p. 33895 - 33900 6 p.

Research output: Contribution to journalArticle (Academic Journal)

226 Citations (Scopus)
2001
1999
130 Citations (Scopus)