Dr J L R Anderson

BSc, PhD(H.-W.)

  • BS8 1TD

20042021

Research output per year

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Personal profile

Research interests

The design of new proteins and enzymes remains one of the great challenges in biochemistry and tests our fundamental understanding of both the nature of protein as a material and the principles of enzymatic catalysis. Unlocking the exceptionally diverse and powerful array of chemistries exhibited by natural enzymes promises routes to new drugs, therapies and green industrial processes.

Most approaches to this end have focused on modifying natural enzymes to impart new or altered catalytic function. The problems that often hinder the re-engineering of naturally evolved proteins and enzymes are due to the layers of complexity that nature incorporates through natural selection into a protein’s complex 3D structure.

Simplified manmade protein scaffolds offer a means to avoid such complexity, learn the principles guiding functional protein assembly and render the modular assembly of enzymatic function a tangible reality. This approach is illustrated through the assembly of artificial oxygen binding proteins that reproduce the function of natural proteins such as myoglobin in simple heme-binding 4-helix bundles untouched by natural selection. The tractable design process that we employ resolves the roles of individual amino acids with their function and opens the door to the powerful oxygenic catalysis common to heme-containing enzymes.

In my laboratory, we use this simple protein design approach to construct artificial oxidoreductase enzymes that integrate functional elements common to natural redox enzymes - e.g. electron/proton transfer, ligand/substrate binding and light harvesting - in a discrete manmade protein that is wholly fabricated within a living organism.

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Projects

Research Output

  • 28 Article (Academic Journal)
  • 3 Review article (Academic Journal)
  • 1 Letter (Academic Journal)
  • 1 Special issue (Academic Journal)
Open Access
File
  • 1 Citation (Scopus)
    43 Downloads (Pure)

    Rewiring the “Push-Pull” Catalytic Machinery of a Heme Enzyme Using an Expanded Genetic Code

    Ortmayer, M., Fisher, K., Basran, J., Wolde-Michael, E. M., Heyes, D. J., Levy, C., Lovelock, S. L., Anderson, J. L. R., Raven, E. L., Hay, S., Rigby, S. E. J. & Green, A. P., 21 Feb 2020, In : ACS Catalysis. 10, 4, p. 2735-2746 12 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • Photoswitchable Phase Separation and Oligonucleotide Trafficking in DNA Coacervate Microdroplets

    Martin, N., Tian, L., Spencer, D., Coutable-Pennarun, A., Anderson, J. L. R. & Mann, S., 27 Sep 2019, In : Angewandte Chemie - International Edition. 58, 41, p. 14594-14598 6 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • 6 Citations (Scopus)

    Activities

    • 1 Participation in workshop, seminar, course
    • 1 Fellowship awarded competitively

    Computationally Directed Protein Design Workshop

    Dek Woolfson (Participant), , Fabio Parmeggiani (Participant), , Ross Anderson (Participant), , Kathleen Sedgley (Participant), & Tom Bowker (Participant)

    2018

    Activity: Participating in or organising an event typesParticipation in workshop, seminar, course

    University Research Fellowship - The Functional Assembly of Artificial Oxidoreductases.

    J L R Anderson (Recipient)

    1 Oct 20091 Oct 2014

    Activity: Other activity typesFellowship awarded competitively

    Thesis

    A Promiscuous and Catalytically Proficient De Novo Carbene Transferase

    Author: Stenner, R. A., 12 May 2020

    Supervisor: Anderson, R. (Supervisor) & Seddon, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Biocrystals: Growth, Synthesis and Materials

    Author: Abu El Magd, N., 31 Mar 2020

    Supervisor: Patil, A. (Supervisor) & Anderson, R. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Computational design, construction, and characterisation of artificial peroxidases

    Author: Jenkins, J., 19 Mar 2019

    Supervisor: Anderson, R. (Supervisor) & Mulholland, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File