Projects per year
My research group investigates how the organism responds and adapts to stressful events.
Major research interests are:
The signalling, epigenetic and genomic mechanisms in the brain underlying stress-related learning and memory processes.
The regulation of the hypothalamic-pituitary-adrenal (HPA) axis under baseline and stress conditions.
The physiological and neurobiological mechanisms underlying the beneficial effects of voluntary exercise on stress coping, HPA axis regulation, and anxiety-related and cognitive behaviour.
My research group investigates how the organism responds and adapts to stressful events. The emphasis is on how we learn and form memories of emotionally stressful events in our lives so we can respond better if such events should reoccur.
Our research programme addresses the role of signalling, epigenetic and genomic processes in the brain in the consolidation of adaptive behavioural responses and memory. Furthermore, we are investigating the role of adult neurogenesis in the dentate gyrus in these processes and responses.
Behavioural responses and memory formation are investigated in the forced swim test, Morris water maze learning and contextual fear conditioning. Our neuroanatomical and molecular expertise includes immuno-fluorescence analysis, lentiviral technology (in collaboration with Professor James Uney (UoB)) and state-of-the-art epigenetic methods such as chromatin-immuno-precipitation (nChIP, xChIP), next generation Illumina sequencing and bisulfite sequencing (in collaboration with Dr. Jon Mill, King’s College London).
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Epigenetic regulation of stress-induced glucocorticoid action in the dentate gyrus and its behavioural implications
1/09/20 → 31/08/23
Mifsud, K. R., Kennedy, C. L. M., Salatino, S., Sharma, E., Price, E. M., Haque, S. N., Gialeli, A., Goss, H. M., Panchenko, P. E., Broxholme, J., Engledow, S., Lockstone, H., Cordero Llana, O. & Reul, J. M. H. M., Dec 2021, In: Nature Communications. 12, 1, 4737.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile18 Downloads (Pure)
Haque, S., Mifsud, K. R., Price, E. & Reul, J. M. H. M., Jan 2021, Stress: Genetics, Epigenetics and Genomics. Amsterdam:Elsevier, p. 215-227
Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male miceHäusl, A. S., Brix, L. M., Hartmann, J., Pöhlmann, M. L., Lopez, J-P., Menegaz, D., Brivio, E., Engelhardt, C., Roeh, S., Bajaj, T., Rudolph, L., Stoffel, R., Hafner, K., Goss, H. M., Reul, J. M. H. M., Deussing, J. M., Eder, M., Ressler, K. J., Gassen, N. C., Chen, A. & 1 others, , Jul 2021, In: Molecular Psychiatry. 26, 7, p. 3060-3076 17 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile7 Citations (Scopus)11 Downloads (Pure)