J S Miners

2024

Altered Gene Expression Within the Renin–Angiotensin System in Normal Aging and Dementia

Tayler, H. M., Maclachlan, R., Güzel, Ö., Fisher, R. A., Skrobot, O. A., Abulfadl, M. A., Kehoe, P. G. & Miners, J. S., 1 Jan 2024, In: Journals of Gerontology, Series A. 79, 1, 10 p., glad241.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease

Tsartsalis, S., Sleven, H., Fancy, N., Wessely, F., Smith, A. M., Willumsen, N., Cheung, T. K. D., Rokicki, M. J., Chau, V., Ifie, E., Khozoie, C., Ansorge, O., Yang, X., Jenkyns, M. H., Davey, K., McGarry, A., Muirhead, R. C. J., Debette, S., Jackson, J. S. & Montagne, A. & 6 others, Owen, D. R., Miners, J. S., Love, S., Webber, C., Cader, M. Z. & Matthews, P. M., 12 Mar 2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 19 p., 2243.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

21 Citations (Scopus)

Association between plasma angiotensin converting enzyme 1 level and cognition over 12-years: The Look AHEAD Study

Yasar, S., Anderson, A., Hayden, K. M., Espeland, M. A., Carmichael, O. T., Clark, J. M., Carlson, M. C., Asby, D., Kehoe, P. G. & Miners, J. S., 1 Dec 2024.

Research output: Contribution to conference › Conference Poster › peer-review

Open Access

Dysregulation of the renin-angiotensin system in vascular dementia

Tayler, H. M., Skrobot, O. A., Baron, D. H., Kehoe, P. G. & Miners, J. S., 20 Jun 2024, In: Brain Pathology. 34, 4, 12 p., e13251.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease

Van Hulle, C., Ince, S., Okonkwo, O. C., Bendlin, B. B., Johnson, S. C., Carlsson, C. M., Asthana, S., Love, S., Blennow, K., Zetterberg, H. & Miners, J. S., 5 Jan 2024, (E-pub ahead of print) In: Translational Psychiatry. 14, 1, 8 p., 3.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

9 Citations (Scopus)

sPDGFRβ and neuroinflammation are associated with AD biomarkers and differ by race: The ASCEND Study

Butts, B., Huang, H., Hu, W. T., Kehoe, P. G., Miners, J. S., Verble, D. D., Zetterberg, H., Zhao, L., Trotti, L. M., Benameur, K., Scorr, L. M. & Wharton, W., 1 Feb 2024, In: Alzheimer's and Dementia. 20, 2, p. 1175-1189 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

5 Citations (Scopus)

2023

Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer's disease pathology in mouse models of Alzheimer's disease

Maclachlan, R. A., Evans, C., Chai, S., Good, M., Kehoe, P. G. & Miners, J. S., 1 Jan 2023, In: Aging Brain. 3, 100062.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

3 Citations (Scopus)

77 Downloads (Pure)

Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer's disease

van Hulle, C., Ince, S., Jonaitis, E., Okonkwo, O. C., Bendlin, B., Johnson, S., Carlsson, C., Asthana, S., Love, S., Blennow, K., Zetterberg, H. & Miners, J. S., 18 Apr 2023, (Research square).

Research output: Working paper › Preprint

Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage

Tayler, H. M., MacLachlan, R., Güzel, Ö., Miners, J. S. & Love, S., 4 Apr 2023, In: Brain Communications. 5, 2, fcad112.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

8 Citations (Scopus)

SARS-CoV-2 targets pericytes to restrict blood flow within the brain

Miners, J. S., Fisher, R. A. & Love, S., 1 Feb 2023, In: Brain. 146, 2, p. 418-420 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

1 Citation (Scopus)

46 Downloads (Pure)

2022

Dysregulation of ACE-1 in Normal Aging and the Early Stages of Alzheimer's Disease

MacLachlan, R., Kehoe, P. G. & Miners, J. S., 9 Apr 2022, In: Journals of Gerontology, Series A. 77, 9, p. 1775-1783 9 p., glac083.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

14 Citations (Scopus)

70 Downloads (Pure)

Late-life blood pressure and markers of vascular and disease pathology in Alzheimer’s, vascular, and mixed dementia

Tayler, H. M., Guzel, O., MacLachlan, R. A., Miners, J. S. & Love, S., 9 Jun 2022, (Unpublished).

Research output: Contribution to conference › Conference Poster › peer-review

Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives

Fisher, R. A., Miners, J. S. & Love, S., 28 Oct 2022, In: Brain Pathology. 32, 6, e13061.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

File

54 Citations (Scopus)

261 Downloads (Pure)

2021

Mediators of cerebral hypoperfusion and blood-brain barrier leakiness in Alzheimer's disease, vascular dementia and mixed dementia

Tayler, H., Miners, J. S., Güzel, Ö., MacLachlan, R. & Love, S., 1 Jul 2021, In: Brain Pathology. 31, 4, 12 p., e12935.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

59 Citations (Scopus)

165 Downloads (Pure)

Pericyte Contractile Responses to Endothelin-1 and Aβ Peptides: Assessment by Electrical Impedance Assay

Hibbs, E., Love, S. & Miners, J. S., 20 Aug 2021, In: Frontiers in Cellular Neuroscience. 15, p. 723953 723953.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

16 Citations (Scopus)

64 Downloads (Pure)

Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease

Asby, D., Boche, D., Allan, S., Love, S. & Miners, J. S., 28 Jul 2021, In: Brain. 144, 6, p. 1869-1883 15 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

49 Citations (Scopus)

139 Downloads (Pure)

2020

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

Evans, C., Miners, J. S., Piva, G., Willis, C. L., Heard, D. M., Kidd, E. J., Good, M. & Kehoe, P. G., 25 Jan 2020, In: Acta Neuropathologica. 139, p. 485–502 18 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

112 Citations (Scopus)

220 Downloads (Pure)

Cognitive impact of COVID-19: looking beyond the short term

Miners, S., Kehoe, P. G. & Love, S., 30 Dec 2020, In: Alzheimer's Research and Therapy. 12, 1, 16 p., 170 (2020).

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

File

152 Citations (Scopus)

188 Downloads (Pure)

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings

McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., Allan, S. M., Bath, P. M., Brezzo, G., Carare, R. O., Carswell, H. V., Clarkson, A. N., Currie, G., Farr, T. D., Fowler, J. H., Good, M., Hainsworth, A. H., Hall, C., Horsburgh, K., Kalaria, R., Kehoe, P. & Lawrence, C. & 18 others, Macleod, M., McColl, B. W., McNeilly, A., Miller, A. A., Miners, S., Mok, V., O'Sullivan, M., Platt, B., Sena, E. S., Sharp, M., Strangeward, P., Szymkowiak, S., Touyz, R. M., Trueman, R. C., White, C., McCabe, C., Work, L. M. & Quinn, T. J., 1 Jul 2020, In: Journal of Cerebral Blood Flow and Metabolism. 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

6 Citations (Scopus)

105 Downloads (Pure)

2019

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease

Grimmer, T., Goldhardt, O., Yakushev, I., Ortner, M., Sorg, C., Diehl-Schmid, J., Förstl, H., Kurz, A., Perneczky, R. & Miners, S., 1 Aug 2019, In: Neurodegenerative Diseases. 19, 1, p. 43-50 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

Biochemical Evidence Of Cerebral Hypoperfusion in Dementia: Associated With β-Secretase, Endothelin-1 And Arteriolosclerosis

Tayler, H., MacLachlan, R., Miners, S. & Love, S., 8 Jun 2019, (Unpublished).

Research output: Contribution to conference › Conference Abstract

Cerebrospinal fluid changes in the renin-angiotensin system in Alzheimer's disease

Kehoe, P. G., Al Mulhim, N. S. K., Zetterberg, H., Blennow, K. & Miners, J. S., 12 Nov 2019, In: Journal of Alzheimer's Disease. 72, 2, p. 525-535 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

20 Citations (Scopus)

291 Downloads (Pure)

CSF evidence of pericyte damage in Alzheimer’s disease is associated with markers of blood-brain barrier dysfunction and disease pathology

Miners, J. S., Kehoe, P. G., Love, S., Zetterberg, H. & Blennow, K., 14 Sept 2019, In: Alzheimer's Research and Therapy. 11, 6 p., 81.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

87 Citations (Scopus)

185 Downloads (Pure)

Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease

Al Mulhim, N., Kehoe, P. & Miners, J. S., 24 Apr 2019, In: Acta Neuropathologica Communications. 7, 1, p. 57 3 p., 57.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

File

5 Citations (Scopus)

228 Downloads (Pure)

Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy

Kiely, A. P., Miners, S., Courteny, R., Strand, C., Love, S. & Holton, J. L., 1 Jun 2019, In: Neuropathology and Applied Neurobiology. 45, 4, p. 347-360 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

16 Citations (Scopus)

191 Downloads (Pure)

KIF5A and KLC1 expression in Alzheimer’s disease: relationship and genetic influences

Hares, K. M., Miners, S., Scolding, N., Love, S. & Wilkins, A., 19 Feb 2019, In: AMRC Open Research. 1, 22 p., 1.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

263 Downloads (Pure)

2018

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease

Miners, J. S., Schulz, I. & Love, S., 1 Jan 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 1, p. 103-115 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

160 Citations (Scopus)

496 Downloads (Pure)

VEGFR1 and VEGFR2 in Alzheimer's Disease

Harris, R., Miners, J. S., Allen, S. & Love, S., 2018, In: Journal of Alzheimer's Disease. 61, 2, p. 741-752 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

51 Citations (Scopus)

983 Downloads (Pure)

2017

Angiotensin-III is Increased in Alzheimer's Disease in Association with Amyloid-β and Tau Pathology

Kehoe, P. G., Hibbs, E., Palmer, L. E. & Miners, J. S., 3 May 2017, In: Journal of Alzheimer's Disease. 58, 1, p. 203-214 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

39 Citations (Scopus)

524 Downloads (Pure)

Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ

Miners, J. S., Clarke, P. & Love, S., May 2017, In: Brain Pathology. 27, 3, p. 305–313 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

57 Citations (Scopus)

506 Downloads (Pure)

Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies

Miners, J. S. & Love, S., 6 Apr 2017, In: Journal of Neurochemistry. 141, 2, p. 275-286 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

5 Citations (Scopus)

272 Downloads (Pure)

Overexpression of kinesin superfamily motor proteins in Alzheimer’s Disease

Hares, K., Miners, S., Cook, A., Rice, C., Scolding, N., Love, S. & Wilkins, A., 7 Nov 2017, In: Journal of Alzheimer's Disease. 60, 4, p. 1511-1524 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

32 Citations (Scopus)

679 Downloads (Pure)

Small vessel disease, neurovascular regulation and cognitive impairment: post-mortem studies reveal a complex relationship, still poorly understood

Love, S. & Miners, S., 15 Jul 2017, In: Clinical Science. 131, 14, p. 1579-1589 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

18 Citations (Scopus)

397 Downloads (Pure)

2016

Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-β and tau pathology

Kehoe, P. G., Wong, S., Al Mulhim, N. S. K., Palmer, L. E. & Miners, J. S., 25 Nov 2016, In: Alzheimer's Research and Therapy. 8, 1, 10 p., 50.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

158 Citations (Scopus)

398 Downloads (Pure)

Cerebral Hypoperfusion and the Energy Deficit in Alzheimer's Disease

Love, S. & Miners, J. S., Sept 2016, In: Brain Pathology. 26, 5, p. 607-617 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

56 Citations (Scopus)

502 Downloads (Pure)

Cerebrovascular disease in ageing and Alzheimer's disease

Love, S. & Miners, J. S., May 2016, In: Acta Neuropathologica. 131, 5, p. 645-658 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

236 Citations (Scopus)

434 Downloads (Pure)

Effects of hypertension and anti-hypertensive treatment on Aβ plaque load, Aβ–synthesising and –degrading enzymes in frontal cortex

Ashby, E. L., Miners, J. S., Kehoe, P. G. & Love, S., 22 Feb 2016, In: Journal of Alzheimer's Disease. 50, 4, p. 1191-1203 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

51 Citations (Scopus)

598 Downloads (Pure)

Pathophysiology of hypoperfusion of the precuneus in early Alzheimer’s disease

Miners, J. S., Palmer, J. C. & Love, S., Jul 2016, In: Brain Pathology. 26, 4, p. 533-541 9 p., 12331.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

84 Citations (Scopus)

394 Downloads (Pure)

2015

Investigation of Aβ phosphorylated at serine 8 (pAβ) in Alzheimer's disease, dementia with Lewy bodies and vascular dementia

Ashby, E. L., Miners, J. S., Kumar, S., Walter, J., Love, S. & Kehoe, P. G., Jun 2015, In: Neuropathology and Applied Neurobiology. 41, 4, p. 428-44 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

19 Citations (Scopus)

Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer's disease and vascular dementia

Thomas, T., Miners, S. & Love, S., 15 Feb 2015, In: Brain. 138, 4, p. 1059-1069 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

152 Citations (Scopus)

White matter hypoperfusion and damage in dementia: post-mortem assessment

Love, S. & Miners, J. S., Jan 2015, In: Brain Pathology. 25, 1, p. 99-107 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

32 Citations (Scopus)

2014

Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1

Miners, J., Renfrew, R., Swirski, M. & Love, S., 5 Dec 2014, In: Acta Neuropathologica Communications. 2, 1, p. 164

Research output: Contribution to journal › Article (Academic Journal) › peer-review

15 Citations (Scopus)

Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes: Divergent effects of multifunctional enzymes

Miners, J. S., Palmer, J. C., Tayler, H., Palmer, L. E., Ashby, E., Kehoe, P. G. & Love, S., 11 Sept 2014, In: Frontiers in Aging Neuroscience. 6, 13 p., 238.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

41 Citations (Scopus)

293 Downloads (Pure)

Differential Changes in Aβ42 and Aβ40 with Age

Miners, J. S., Jones, R. & Love, S., 6 Feb 2014, In: Journal of Alzheimer's Disease.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

25 Citations (Scopus)

Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson's disease

Swirski, M., Miners, J. S., de Silva, R., Lashley, T., Ling, H., Holton, J., Revesz, T. & Love, S., 2014, In: Alzheimer's Research and Therapy. 6, 5-8, p. 77

Research output: Contribution to journal › Article (Academic Journal) › peer-review

78 Citations (Scopus)

Reduced vascular endothelial growth factor and capillary density in the occipital cortex in dementia with Lewy bodies

Miners, S., Moulding, H., de Silva, R. & Love, S., 13 Feb 2014, In: Brain Pathology.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

43 Citations (Scopus)

2013

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer's Disease or in Aging

Glennon, E. B. C., Whitehouse, I. J., Miners, J. S., Kehoe, P. G., Love, S., Kellett, K. A. B. & Hooper, N. M., 21 Oct 2013, In: PLoS ONE. 8, 10, p. e78806 11 p., 78806.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

56 Citations (Scopus)

Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage

Whitehouse, I. J., Miners, J. S., Glennon, E. B. C., Kehoe, P. G., Love, S., Kellett, K. A. B. & Hooper, N. M., 5 Apr 2013, In: PLoS ONE. 8, 4, p. e59554 8 p., 59554.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

34 Citations (Scopus)

2012

Convection-enhanced delivery of neprilysin: A Novel Amyloid-β-Degrading Therapeutic Strategy

Barua, N. U., Miners, J. S., Bienemann, A. S., Wyatt, M. J., Welser, K., Tabor, A. B., Hailes, H. C., Love, S. & Gill, S. S., 2012, In: Journal of Alzheimer's Disease.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

40 Citations (Scopus)

Genetic variation in MME in relation to neprilysin protein and enzyme activity, Aβ levels, and Alzheimer's disease risk

Miners, S., van Helmond, Z., Barker, R., Passmore, P. A., Johnston, J. A., Todd, S., McGuinness, B. M., Panza, F., Seripa, D., Solfrizzi, V., Love, S., Prince, J. A. & Kehoe, P. G., 27 Mar 2012, In: International journal of molecular epidemiology and genetics. 3, 1, p. 30-38 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

Dr J S Miners

Research output

Search results