Projects per year
Personal profile
Research interests
Find out more about the team here.
Our ability to learn and remember information about our environment is underpinned by synaptic plasticity. This process is fundamental to shaping who we are as individuals and is also implicated in many neurological and psychiatric disorders. Memory is fundamentally dependent on the behavioural context of learnt information and we aim to investigate the contextual factors that are important for the encoding of memory by synaptic plasticity at a neuronal circuit level.
We study this by considering the factors that regulate the induction of synaptic plasticity and the mechanisms underlying its expression. Currently this involves projects in the following areas:
1) The role of acetylcholine and other neuromodulators in synaptic circuit function.
2) Impairment of neural plasticity and adaptive representations by genetic risk factors for psychiatric disorders.
3) The mechanisms underlying postsynaptic neurotransmitter receptor trafficking.
4) A data architecture system for open access neuroscience data.
We use a combination of techniques including in vitro and in vivo electrophysiology, 2-photon imaging, optogenetics, behavioural assays and computational modelling.
Structured keywords and research groupings
- Cognitive Neuroscience
- Memory
- Brain and Behaviour
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Collaborations and top research areas from the last five years
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Impairment of neural plasticity and adaptive representations by genetic risk factors for schizophrenia
1/10/23 → 30/09/28
Project: Research, Parent
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Regulation of plateau potentials by dendritically targeted inhibitory synaptic transmission - BB/V001728/1
23/03/21 → 22/03/24
Project: Research
Research output
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A mild impairment in reversal learning in a bowl‐digging substrate deterministic task but not other cognitive tests in the Dlg2+/− rat model of genetic risk for psychiatric disorder
Griesius, S., Waldron, S., Kamenish, K. A., Cherbanich, N., Wilkinson, L. S., Thomas, K. L., Hall, J., Mellor, J. R., Dwyer, D. M. & Robinson, E. S. J., 10 Sept 2023, (E-pub ahead of print) In: Genes, Brain and Behavior. e12865.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors
Nair, J. D., Wilkinson, K. A., Yucel, B. P., Mulle, C., Vissel, B., Mellor, J. R. & Henley, J. M., 20 Oct 2023, In: iScience. 26, 10, 107708.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder
Waldron, S., Pass, R., Griesius, S., Mellor, J. R., Robinson, E. S. J., Thomas, K. L., Wilkinson, L. S., Humby, T., Hall, J. & Dwyer, D. M., 1 Apr 2022, In: Genes, Brain and Behavior. 21, 4, 14 p., e12797.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile1 Citation (Scopus)52 Downloads (Pure)
Datasets
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Spine calcium model
Atherton, L. (Creator), Mellor, J. R. (Data Manager), Tigaret, C. (Creator), Shaikh, N. (Creator), Olivo, V. (Creator), Sadowski, J. (Creator), Betterton, R. (Creator), Chamberlain, S. (Creator), Ruivo, L. T. G. (Creator) & Griffith, T. J. O. (Creator), University of Bristol, 7 Jun 2013
DOI: 10.5523/bris.728sv451ogv61bwiazm1a5t29, http://data.bris.ac.uk/data/dataset/728sv451ogv61bwiazm1a5t29
Dataset
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PURE-LET denoising code
Tigaret, C. (Creator), Atherton, L. (Creator), Shaikh, N. (Creator), Chamberlain, S. (Creator), Griffith, T. J. O. (Creator), Ruivo, L. T. G. (Creator), Sadowski, J. (Creator), Olivo, V. (Creator), Betterton, R. (Creator) & Mellor, J. R. (Data Manager), University of Bristol, 5 Jun 2013
DOI: 10.5523/bris.dss2hubx4pk9zvg9x83k2mi2, http://data.bris.ac.uk/data/dataset/dss2hubx4pk9zvg9x83k2mi2
Dataset