Projects per year
Personal profile
Research interests
Our ability to learn and remember information about our environment is underpinned by synaptic plasticity. This process is fundamental to shaping who we are as individuals and is also implicated in many neurological and psychiatric disorders. Memory is fundamentally dependent on the behavioural context of learnt information and we aim to investigate the contextual factors that are important for the encoding of memory by synaptic plasticity at a neuronal circuit level.
We study this by considering the factors that regulate the induction of synaptic plasticity and the mechanisms underlying its expression. Currently this involves projects in the following areas:
1) The role of acetylcholine and other neuromodulators in synaptic circuit function.
2) The patterns of activity that induce synaptic plasticity.
3) The mechanisms underlying postsynaptic neurotransmitter receptor trafficking.
We use a combination of techniques including in vitro and in vivo electrophysiology, 2-photon imaging, optogenetics, behavioural assays and computational modelling.
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Network
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Regulation of plateau potentials by dendritically targeted inhibitory synaptic transmission - BB/V001728/1
23/03/21 → 22/03/24
Project: Research
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Neural adaptation to sensory stimuli by regulation of dendritic spikes and synaptic plasticity
1/04/18 → 30/06/22
Project: Research
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AI-driven brain modelling for neuromodulated cognitive enhancement
1/09/22 → 28/02/23
Project: Research
Research output
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Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder
Waldron, S., Pass, R., Griesius, S., Mellor, J. R., Robinson, E. S. J., Thomas, K. L., Wilkinson, L. S., Humby, T., Hall, J. & Dwyer, D. M., 1 Apr 2022, In: Genes, Brain and Behavior. 21, 4, 14 p., e12797.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile16 Downloads (Pure) -
PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice and Fruit Flies
Al-Amri, A. H., Armstrong, P., Amici, M., Ligneul, C., Mellor, J. R. & Clapcote, S. J., 11 Jan 2022, (E-pub ahead of print) In: Biological Psychiatry. 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile5 Downloads (Pure) -
Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity
Griesius, S., O'Donnell, C., Waldron, S., Thomas, K. L., Robinson, E. S. J. & Mellor, J. R., 3 Feb 2022, (E-pub ahead of print) In: Neuropsychopharmacology. 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile18 Downloads (Pure)
Datasets
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Spine calcium model
Atherton, L. (Creator), Mellor, J. R. (Data Manager), Tigaret, C. (Creator), Shaikh, N. (Creator), Olivo, V. (Creator), Sadowski, J. (Creator), Betterton, R. (Creator), Chamberlain, S. (Creator), Ruivo, L. T. G. (Creator) & Griffith, T. J. O. (Creator), University of Bristol, 7 Jun 2013
DOI: 10.5523/bris.728sv451ogv61bwiazm1a5t29, http://data.bris.ac.uk/data/dataset/728sv451ogv61bwiazm1a5t29
Dataset
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PURE-LET denoising code
Tigaret, C. (Creator), Atherton, L. (Creator), Shaikh, N. (Creator), Chamberlain, S. (Creator), Griffith, T. J. O. (Creator), Ruivo, L. T. G. (Creator), Sadowski, J. (Creator), Olivo, V. (Creator), Betterton, R. (Creator) & Mellor, J. R. (Data Manager), University of Bristol, 5 Jun 2013
DOI: 10.5523/bris.dss2hubx4pk9zvg9x83k2mi2, http://data.bris.ac.uk/data/dataset/dss2hubx4pk9zvg9x83k2mi2
Dataset