Projects per year
Personal profile
Research interests
Our ability to learn and remember information about our environment is underpinned by synaptic plasticity. This process is fundamental to shaping who we are as individuals and is also implicated in many neurological and psychiatric disorders. Memory is fundamentally dependent on the behavioural context of learnt information and we aim to investigate the contextual factors that are important for the encoding of memory by synaptic plasticity at a neuronal circuit level.
We study this by considering the factors that regulate the induction of synaptic plasticity and the mechanisms underlying its expression. Currently this involves projects in the following areas:
1) The role of acetylcholine and other neuromodulators in synaptic circuit function.
2) The patterns of activity that induce synaptic plasticity.
3) The mechanisms underlying postsynaptic neurotransmitter receptor trafficking.
We use a combination of techniques including in vitro and in vivo electrophysiology, 2-photon imaging, optogenetics, behavioural assays and computational modelling.
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Projects
Neural adaptation to sensory stimuli by regulation of dendritic spikes and synaptic plasticity
1/04/18 → 30/09/21
Project: Research
Plasticity of inhibitory synaptic transmission in the hippocampus
1/10/16 → 30/09/19
Project: Research
Regulation of spine Ca2+ dynamics and spike timing-dependent synaptic plasticity by muscarinic acetylcholine receptors
1/10/12 → 1/10/15
Project: Research
Research Output
A Bayesian predictive approach for dealing with pseudoreplication
Lazic, S. E., Mellor, J. R., Ashby, M. C. & Munafo, M. R., 11 Feb 2020, In : Scientific Reports. 10, 10 p., 2366 (2020).Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Comparison of conventional and rapid acting antidepressants in a rodent probabilistic reversal learning task
Wilkinson, M. P., Grogan, J. P., Mellor, J. R. & Robinson, E. S. J., 23 Feb 2020, In : Brain and Neuroscience Advances. 4, 11 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
Udakis, M., Pedrosa, V., Chamberlain, S. E. L., Clopath, C. & Mellor, J. R., 2 Sep 2020, In : Nature Communications. 11, 1, p. 4395Research output: Contribution to journal › Article (Academic Journal)
Datasets
PURE-LET denoising code
Tigaret, C. (Creator), Atherton, L. (Creator), Shaikh, N. (Creator), Chamberlain, S. (Creator), Griffith, T. J. O. (Creator), Ruivo, L. T. G. (Creator), Sadowski, J. (Creator), Olivo, V. (Creator), Betterton, R. (Creator) & Mellor, J. R. (Data Manager), University of Bristol, 5 Jun 2013
DOI: 10.5523/bris.dss2hubx4pk9zvg9x83k2mi2, http://data.bris.ac.uk/data/dataset/dss2hubx4pk9zvg9x83k2mi2
Dataset
Spine calcium model
Atherton, L. (Creator), Mellor, J. R. (Data Manager), Tigaret, C. (Creator), Shaikh, N. (Creator), Olivo, V. (Creator), Sadowski, J. (Creator), Betterton, R. (Creator), Chamberlain, S. (Creator), Ruivo, L. T. G. (Creator) & Griffith, T. J. O. (Creator), University of Bristol, 7 Jun 2013
DOI: 10.5523/bris.728sv451ogv61bwiazm1a5t29, http://data.bris.ac.uk/data/dataset/728sv451ogv61bwiazm1a5t29
Dataset
Supervised Work
Noradrenergic modulation of hippocampal CA1 and CA3 networks
Author: Bacon, T. J., 24 Mar 2020Supervisor: Mellor, J. R. (Supervisor) & Pickering, A. E. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)