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Research output per year

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Personal profile

Research interests

Our ability to learn and remember information about our environment is underpinned by synaptic plasticity. This process is fundamental to shaping who we are as individuals and is also implicated in many neurological and psychiatric disorders. Memory is fundamentally dependent on the behavioural context of learnt information and we aim to investigate the contextual factors that are important for the encoding of memory by synaptic plasticity at a neuronal circuit level.

We study this by considering the factors that regulate the induction of synaptic plasticity and the mechanisms underlying its expression. Currently this involves projects in the following areas:

1)      The role of acetylcholine and other neuromodulators in synaptic circuit function.

2)      The patterns of activity that induce synaptic plasticity.

3)      The mechanisms underlying postsynaptic neurotransmitter receptor trafficking.

We use a combination of techniques including in vitro and in vivo electrophysiology, 2-photon imaging, optogenetics, behavioural assays and computational modelling.

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Projects

Research Output

A Bayesian predictive approach for dealing with pseudoreplication

Lazic, S. E., Mellor, J. R., Ashby, M. C. & Munafo, M. R., 11 Feb 2020, In : Scientific Reports. 10, 10 p., 2366 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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  • 2 Citations (Scopus)
    53 Downloads (Pure)
    Open Access
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  • 66 Downloads (Pure)

    Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

    Udakis, M., Pedrosa, V., Chamberlain, S. E. L., Clopath, C. & Mellor, J. R., 2 Sep 2020, In : Nature Communications. 11, 1, p. 4395

    Research output: Contribution to journalArticle (Academic Journal)

  • Datasets

    PURE-LET denoising code

    Tigaret, C. (Creator), Atherton, L. (Creator), Shaikh, N. (Creator), Chamberlain, S. (Creator), Griffith, T. J. O. (Creator), Ruivo, L. T. G. (Creator), Sadowski, J. (Creator), Olivo, V. (Creator), Betterton, R. (Creator) & Mellor, J. R. (Data Manager), University of Bristol, 5 Jun 2013

    Dataset

    Spine calcium model

    Atherton, L. (Creator), Mellor, J. R. (Data Manager), Tigaret, C. (Creator), Shaikh, N. (Creator), Olivo, V. (Creator), Sadowski, J. (Creator), Betterton, R. (Creator), Chamberlain, S. (Creator), Ruivo, L. T. G. (Creator) & Griffith, T. J. O. (Creator), University of Bristol, 7 Jun 2013

    Dataset

    Supervised Work

    Noradrenergic modulation of hippocampal CA1 and CA3 networks

    Author: Bacon, T. J., 24 Mar 2020

    Supervisor: Mellor, J. R. (Supervisor) & Pickering, A. E. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)