Personal profile
Research interests
Find out more about the team here.
Our ability to learn and remember information about our environment is underpinned by synaptic plasticity. This process is fundamental to shaping who we are as individuals and is also implicated in many neurological and psychiatric disorders. Memory is fundamentally dependent on the behavioural context of learnt information and we aim to investigate the contextual factors that are important for the encoding of memory by synaptic plasticity at a neuronal circuit level.
We study this by considering the factors that regulate the induction of synaptic plasticity and the mechanisms underlying its expression. Currently this involves projects in the following areas:
1) The role of acetylcholine and other neuromodulators in synaptic circuit function.
2) Impairment of neural plasticity and adaptive representations by genetic risk factors for psychiatric disorders.
3) The mechanisms underlying postsynaptic neurotransmitter receptor trafficking.
4) A data architecture system for open access neuroscience data.
We use a combination of techniques including in vitro and in vivo electrophysiology, 2-photon imaging, optogenetics, behavioural assays and computational modelling.
Research Groups and Themes
- Cognitive Neuroscience
- Memory
- Brain and Behaviour
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Collaborations and top research areas from the last five years
Research output
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Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping
Udakis, M., Claydon, M. D. B., Zhu, H. W., Oakes, E. C. & Mellor, J. R., 11 Nov 2025, In: Nature Communications. 16, 1, 16 p., 9912.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access3 Citations (Scopus) -
APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors
Dunot, J., Moreno, S., Gandin, C., Pousinha , P. A., Ashby, M. C., Mellor, J. R. & al., E., 14 Jun 2024, (E-pub ahead of print) In: Neuron. 112, 16, p. 2708-2720.e9Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access6 Citations (Scopus) -
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Palacios-Filardo, J., Udakis, M., Mellor, J. R. & al., E., Dec 2021, In: Nature Communications. 12, 1, 5475.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile28 Citations (Scopus)116 Downloads (Pure)
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Regulation of synaptic function by intramembrane proteolysis
Mellor, J. R. (Principal Investigator)
1/08/24 → 31/07/27
Project: Research
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Impairment of neural plasticity and adaptive representations by genetic risk factors for schizophrenia
Mellor, J. R. (Principal Investigator) & Hanley, J. G. (Principal Investigator)
1/10/23 → 30/09/28
Project: Research, Parent
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AI-driven modelling for cortex-wide neuromodulated learning
Mellor, J. R. (Principal Investigator)
15/02/23 → 14/12/24
Project: Research
Datasets
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Spine calcium model
Atherton, L. (Creator), Mellor, J. (Data Manager), Tigaret, C. (Creator), Shaikh, N. (Creator), Olivo, V. (Creator), Sadowski, J. (Creator), Betterton, R. (Creator), Chamberlain, S. (Creator), Ruivo, L. T. G. (Creator) & Griffith, T. (Creator), University of Bristol, 7 Jun 2013
DOI: 10.5523/bris.728sv451ogv61bwiazm1a5t29, http://data.bris.ac.uk/data/dataset/728sv451ogv61bwiazm1a5t29
Dataset
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PURE-LET denoising code
Tigaret, C. (Creator), Atherton, L. (Creator), Shaikh, N. (Creator), Chamberlain, S. (Creator), Griffith, T. (Creator), Ruivo, L. T. G. (Creator), Sadowski, J. (Creator), Olivo, V. (Creator), Betterton, R. (Creator) & Mellor, J. (Data Manager), University of Bristol, 5 Jun 2013
DOI: 10.5523/bris.dss2hubx4pk9zvg9x83k2mi2, http://data.bris.ac.uk/data/dataset/dss2hubx4pk9zvg9x83k2mi2
Dataset