Professor Jan Frayne

B.Sc.(Nott.), Ph.D.(Bristol)

  • BS8 1TD

1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 62 Article (Academic Journal)
  • 8 Conference Contribution (Conference Proceeding)
  • 1 Chapter in a book

Activation of KLF1 enhances the differentiation and maturation of red blood cells from human pluripotent stem cells

Yang, C-T., Ma, R., Frayne, J. & Forrester, LM., Apr 2017, In : Stem Cells. 35, 4, p. 886–897 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
18 Citations (Scopus)
392 Downloads (Pure)

Analysis of the differential proteome of human erythroblasts during in vitro erythropoiesis by 2-D DIGE

Richardson, BM., Heesom, KJ., Parsons, SF., Anstee, DJ. & Frayne, J., Sep 2009, In : Proteomics - Clinical applications. 3 (9), p. 1123 - 1134 12 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

Trakarnsanga, K., Griffiths, R. E., Wilson, M. C., Blair, A., Satchwell, T. J., Meinders, M., Cogan, N., Kupzig, S., Kurita, R., Nakamura, Y., Toye, A. M., Anstee, D. J. & Frayne, J., 14 Mar 2017, In : Nature Communications. 8, 7 p., 14750.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
49 Citations (Scopus)
567 Downloads (Pure)

A Novel EKLF Mutation in a Patient with Dyserythropoietic Anemia: The First Association of EKLF with Disease in Man.

Singleton, B. K., Fairweather, V. S. S., Lau, W., Parsons, S. F., Burton, N. M., Frayne, J., Brady, R. L. & Anstee, D. J., 20 Nov 2009, In : Blood. 114, 22, p. 72-72 1 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Binding of a biotinylated oxytocin ligand in the rat testis

Frayne, J. & Nicholson, HD., 1992, In : Journal of Reproduction and Fertility Abstract Series. 10, p. 30 - 30 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Blood group phenotypes resulting from mutations in erythroid transcription factors.

Singleton, B. K., Frayne, J. & Anstee, D. J., Nov 2012, In : Current Opinion in Hematology. 19, 6, p. 486-493 8 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Cloning, sequencing and characterisation of rat fertilinβ

McLaughlin, EA., Barker, HL., Frayne, J., Ford, WCL., Jones, R. & Hall, L., 1997, In : Journal of Reproduction and Fertility Abstract Series. 19, p. 17 - 17 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Cloning, sequencing and characterisation of rat fertilin β

McLaughlin, EA., Barker, HL., Frayne, J., Ford, WCL., Jones, R. & Hall, L., 1997, Unknown. Vol. 19. p. 28 - 28 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Cloning and sequence analysis of rat fertilin α and β-developmental expression, procesing and immunolocalisation

McLaughlin, EA., Frayne, J., Barker, HL., Jury, JA., Jones, R., Ford, WCL. & Hall, L., 1997, In : Molec. Hum. Reprod. 3, p. 801 - 809

Research output: Contribution to journalArticle (Academic Journal)

Comparing the two leading erythroid lines BEL-A and HUDEP-2

Daniels, D. E., Downes, D., Ferrer Vicens, I., Ferguson, D. C. J., Singleton, B. K., Wilson, M. C., Trakarnsanga, K., Kurita, R., Nakamura, Y., Anstee, D. J. & Frayne, J., 21 Nov 2019, In : Haematologica. 105, 3, 11 p., 229211.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
172 Downloads (Pure)

Comparison of the proteome of adult and cord erythroid cells, and changes in the proteome following reticulocyte maturation

Wilson, M., Trakarnsanga, K., Heesom, K., Toye, A. & Frayne, J., 1 Jun 2016, In : Molecular and Cellular Proteomics. 15, 6, p. 1938-1946 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
48 Citations (Scopus)
330 Downloads (Pure)

Detection of tetanus toxoid-specific memory T cells in equine lymph nodes but not in peripheral blood.

Frayne, J. & Stokes, C. R., 1995, In : Research in Veterinary Science. 59, 1, p. 79-81

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
22 Citations (Scopus)

Effect of oxytocin on testosterone production by isolated rat Leydig cells is mediated via a specific oxytocin receptor

Frayne, J. & Nicholson, HD., 1995, In : Biology of Reproduction. 52, p. 1268 - 1273

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Effect of synthetic peptides on sperm binding and sperm-egg fusion in the mouse: identity of the putative integrin-binding motif

McLaughlin, EA., Frayne, J., Bloomberg, G. & Hall, L., 1999, In : Journal of Reproduction and Fertility Abstract Series. Abstract Series No 24, p. 8 - 9

Research output: Contribution to journalArticle (Academic Journal)

Effects of LH and cell density on oxytocin production by isolated leydig cells in vitro

Frayne, J. & Nicholson, HD., 1994, Unknown. p. 39 - 39 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Effects of oxytocin on sperm transport in the pubertal rat

Frayne, J., Townsend, D. & Nicholson, HD., 1996, In : Journal of Reproduction and Fertility. 107, p. 299 - 306

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Enhancement of red blood cell transfusion compatibility using CRISPR‐mediated erythroblast gene editing

Hawksworth, J., Satchwell, T., Meinders, M., Daniels, D., Regan, F., Thornton, N., Wilson, M., Dobbe, J. G. G., Streekstra, G. J., Trakarnsanga, K., Heesom, K., Anstee, D., Frayne, J. & Toye, A., 26 Apr 2018, In : EMBO Molecular Medicine. 10, 5, 11 p., e8454.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
12 Citations (Scopus)
242 Downloads (Pure)

Epididymal oxytocin in the rat: its origin and control

Harris, GC., Frayne, J. & Nicholson, HD., 1996, In : International Journal of Andrology. 19, p. 278 - 286

Research output: Contribution to journalArticle (Academic Journal)

Epididymal oxytocin in the rat: its origin and regulation

Harris, GC. & Frayne, J., 1996, In : International Journal of Andrology. 19, p. 278 - 286

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation

Taylor, A., Robson, A., Houghton, B. C., Jepson, C. A., Ford, W. C. L. & Frayne, J., Sep 2013, In : Human Reproduction. 28, 9, p. 2332-2342 11 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Evidence that testicular oxytocin is regulated by pachytene spermatocytes

Frayne, J. & Nicholson, HD., 1995, In : International Journal of Andrology. 18

Research output: Contribution to journalArticle (Academic Journal)

Evidence that testicular oxytocin is regulated by pachytene spermatocytes

Nicholson, HD. & Frayne, J., 1994, British Andrology Society.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Expression and retention of thymidine phosphorylase in cultured reticulocytes as a novel treatment for MNGIE

Meinders, M., Shoemark, D. K., Dobbe, J. G. G., Streekstra, G. J., Frayne, J. & Toye, A. M., 12 Jun 2020, In : Molecular Therapy - Methods and Clinical Development. 17, p. 822-830 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
20 Downloads (Pure)

Expression of extracellular glutathione peroxidase type 5(GPX5) in the rat male reproductive tract

Williams, KM., Frayne, J. & Hall, L., 1998, In : Molecular Human Reproduction. 4, p. 841 - 848

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Expression of extracellular superoxide dismutase in the human male reproductive tract, detected using antisera raised against a recombinant protein

Williams, KM., Frayne, J., McLaughlin, EA. & Hall, L., 1998, In : Molecular Human Reproduction. 4, p. 235 - 242

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Expression of human epididymal glutathione peroxidase in the male reproductive tract.

K, W., Frayne, J. & Hall, L., Feb 1998, In : Boden Conference, Sydney, Australia, February 1998.

Research output: Contribution to journalArticle (Academic Journal)

Fertilin

Hall, L. & Frayne, J., 2002, Wiley Encyclopedia of Molecular Medicine. Creighton, TE. (ed.). John Wiley & Sons, Inc, p. 1265 - 1268

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Genetic manipulation of cell line derived reticulocytes enables dissection of host malaria invasion requirements

Satchwell, T. J., Wright, K. E., Haydn-Smith, K. L., Sánchez-Román Terán, F., Moura, P. L., Hawksworth, J., Frayne, J., Toye, A. M. & Baum, J., 23 Aug 2019, In : Nature Communications. 10, 9 p., 3806 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
115 Downloads (Pure)

Human tMDC III: a sperm protein with a potential role in oocyte recognition

Frayne, J., Hurd, EAC. & Hall, L., Sep 2002, In : Molecular Human Reproduction. 8 (9), p. 817 - 822 6 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Immunolocalisation of oxytocin in the epididymis of the rat

Harris, GC., Frayne, J. & Nicholson, HD., 1995, In : International Journal of Andrology. 18

Research output: Contribution to journalArticle (Academic Journal)

Immunolocalisation of oxytocin in the epidymis of the rat

Harris, GC., Frayne, J. & Nicholson, HD., 1994, British Andrology Society.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL

Trakarnsanga, K., Wilson, M. C., Lau, W. W. Y., Singleton, B. K., Parsons, S. F., Sakuntanaga, P., Kurita, R., Nakamura, Y., Anstee, D. J. & Frayne, J., 2014, In : Haematologica. Aug 8. pii: haematol.2014.110155.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Perkins, A., Xu, X., Higgs, D., Patrinos, G. P., Arnaud, L., Bieker, J. J., Philipsen, S. & KLF1 Consensus Workgroup, 14 Apr 2016, In : Blood. 127, 15, p. 1856-1862 7 p.

Research output: Contribution to journalArticle (Academic Journal)

71 Citations (Scopus)

Localisation of phosphatidylethanolamine-binding protein in the brain and other tissues of the rat

Frayne, J., Ingram, CD., Love, S. & Hall, L., 1999, In : Cell and Tissue Research. 298, p. 415 - 423

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Macaque MDC family of proteins: sequence analysis, tissue distribution and proteolytic processing in the male reproductive tract

Frayne, J., Jury, JA., Barker, HL., Perry, ACF., Jones, R. & Hall, L., 1998, In : Molec. Human Reprod. 4, p. 429 - 437

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Mammalian sperm-egg recognition: does fertilin β have a major role to play?

Frayne, J. & Hall, L., 1999, In : BioEssays. 21, p. 183 - 187

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

MHC Class 11 positive cells and T cells in the equine endometrium throughout the oestrous cycle

Frayne, J. & Stokes, CR., 1994, In : Veterinary Immunology and Immunopathology. 41, p. 55 - 72 17 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes

Singleton, BK., Lau, W., Fairweather, VS., Burton, NM., Wilson, MC., Parsons, SF., Richardson, BM., Trakarnsanga, K., Brady, RL., Anstee, DJ. & Frayne, J., Jul 2011, In : Blood. 118, p. 3137 - 3145 9 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Non-functional fertility genes in humans: contributory factors in reduced male fertility?

Hall, L. & Frayne, J., 1999, In : Human Fertility. 2, p. 36 - 41

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Optimization of an Erythroid Culture System to Reduce the Cost of in vitro Production of Red Blood Cells

Poldee, S., Metheetrairuta, C., Nugoolsuksiri, S., Frayne, J. & Trakarnsanga, T., 2018, In : MethodsX. 5, p. 1626-1632 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
210 Downloads (Pure)

Processing of macaque MDC proteins during epididymal transit

Frayne, J., Jury, JA., Barker, HL. & Hall, L., 1998, In : Boden Conference, Sydney, Australia, February 1998.

Research output: Contribution to journalArticle (Academic Journal)

Qualitative and Quantitative Comparison of the Proteome of Erythroid Cells Differentiated from Human iPSCs and Adult Erythroid Cells by Multiplex TMT Labelling and NanoLC-MS/MS

Trakarnsanga, K., Wilson, M. C., Griffiths, R. E., Toye, A. M., Carpenter, L., Heesom, K. J., Parsons, S. F., Anstee, D. J. & Frayne, J., 2014, In : PLoS ONE. 9, 7, p. e100874

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Rat MDC family of proteins: Sequence analysis, tissue distribution and expression in prepubertal and adult rat testis

Frayne, J., Jury, JA., Barker, HL. & Hall, L., 1997, In : Molecular Reproduction and Development. 48, p. 159 - 167

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)